LEUKEMIA

This study is testing whether combining three chemotherapy drugs can help control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The treatment is for older adults or those who cannot tolerate standard intensive chemotherapy, including some with relapsed…

This study is testing whether a drug called mosunetuzumab, given alone or with other leukemia medications, can clear very low levels of lingering cancer cells in people with chronic lymphocytic leukemia (CLL). The goal is to see if this approach can help control the disease bette…

This study is testing an oral drug called revumenib to see if it can help control leukemia that has returned or not responded to other treatments and is driven by specific genetic changes involving HOX genes. It will enroll about 40 patients aged 12 and older. The main goals are …

This early-stage study is testing whether combining two existing cancer drugs, venetoclax and Vyxeos, is safe for children and young adults whose acute leukemia has returned or hasn't responded to previous treatments. Researchers will give the drugs to a small group of patients t…

This early-stage study is testing a new therapy that uses specially trained immune cells from a donor to try to prevent blood cancers from coming back after a stem cell transplant. The goal is to see if these 'memory-like' natural killer (NK) cells, given with a supporting drug, …

This trial provides expanded access to stem cell transplants for children with serious blood, immune, or metabolic diseases who lack a perfectly matched sibling donor. It uses a special device to remove certain cells from the donor's blood to reduce the risk of a dangerous compli…

This early-phase study is testing the safety of giving two different types of genetically modified immune cell therapies, one after the other, to children and young adults whose B-cell leukemia has come back or hasn't responded to treatment. The goal is to see if a second, experi…

This study is testing whether using a simple early warning system can help patients with serious blood cancers like leukemia and lymphoma. The system uses regular checks of vital signs (like heart rate and breathing) to identify patients at high risk of dangerous complications. I…

This study is testing whether adding a new drug called capivasertib to standard chemotherapy works better for adults with acute leukemia or lymphoblastic lymphoma. Researchers will first find the safest dose, then test if the combination helps patients achieve remission with no d…

This is a first-in-human study to test the safety of a new type of immune cell therapy for adults with acute myeloid leukemia (AML). Researchers will give patients specially trained 'memory-like' natural killer (NK) cells along with a standard drug called venetoclax, aiming to be…

This study is testing whether stopping regular immunoglobulin therapy (with or without preventive antibiotics) works as well as continuing it to prevent serious infections in people with blood cancers like myeloma, leukemia, and lymphoma. Researchers will compare these different …

This trial is testing whether a drug called quizartinib can help prevent a specific type of acute myeloid leukemia (AML) from coming back. It is for adults whose cancer is in remission after initial treatment but who have not had a stem cell transplant. The study will compare two…

This study is testing a combination of three medications given after a stem cell transplant to prevent a dangerous complication called graft-versus-host disease (GVHD). It will enroll 124 adults with leukemia or similar blood cancers who are receiving a transplant from a donor. T…

This early-stage study is testing whether combining two oral drugs, revumenib and mezigdomide, is safe and effective for people with specific types of acute leukemia that have returned or not responded to prior treatments. The trial will enroll about 52 participants aged 12 and o…

This is the first time researchers are giving a new oral drug called BH-30236 to people. The study aims to find a safe dose and see if the drug can help control two aggressive blood cancers—acute myeloid leukemia or myelodysplastic syndrome—that have come back or haven't responde…

This study is testing a combination of several cancer drugs to see if they can help control a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL) in children and young adults whose cancer has come back or did not respond to previous treatment. The trial will enr…

This study aims to see if it's safe to stop antibiotics early for adults with blood cancers who get a fever after chemotherapy, stem cell transplant, or CAR-T therapy. Currently, antibiotics are often continued until white blood cell counts recover, even if no infection is found.…

This study is testing a modified chemotherapy approach for frail adults with acute lymphoblastic leukemia (ALL) who cannot tolerate standard intensive treatments. Researchers are adjusting drug doses and using infusion-based therapy to reduce side effects while trying to control …

This early-stage study is testing a new cell-based therapy called BiTE-EV for adults whose B-cell leukemia has returned or not responded to other treatments. The main goals are to check if the treatment is safe and to see if it helps control the cancer. A very small group of part…

This study is testing whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—is safe and effective for people with two types of blood cancer who have not yet received treatment. It aims to see if this time-limited treatment can deeply reduce or eliminate…

This study is testing a drug called ponatinib in children and teenagers (ages 1 to 18) whose cancers have come back or have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can help control various advanced cancers, including leukem…

This study is testing a new drug called MP0533 for the first time in people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Researchers want to find the safest dose and see if it helps control these blood cancers. The trial will include up to 249 adults whose…

This is a very early study to check if a new drug called Karonudib is safe and tolerable for people with advanced blood cancers like leukemia and lymphoma. It will involve a small group of patients whose disease has come back or hasn't responded to standard treatments. The main g…

This large Phase 3 study is testing whether adding the drug quizartinib to standard chemotherapy helps adults newly diagnosed with a specific type of acute myeloid leukemia (AML) live longer. The trial will enroll 700 patients who test negative for a particular genetic marker (FL…

This study is developing and testing a video game designed to help young leukemia and lymphoma survivors after stem cell transplant. Researchers want to see if the game can encourage better health habits and improve recovery. They're gathering feedback from patients ages 15-39 to…

This is a first-in-human study to test a new drug called CG009301 in adults with blood cancers that have returned or stopped responding to standard treatments. The main goals are to find a safe dose and see how the body processes the drug. About 45 participants will receive the t…

This early-stage trial is testing whether adding an experimental drug called ziftomenib to standard leukemia treatments is safe and tolerable for patients. It focuses on adults with acute myeloid leukemia (AML) that has returned or not responded to prior therapy and has specific …

This study is testing whether a new combination of three drugs can safely control hidden leukemia cells and prevent the cancer from coming back in adults with acute myeloid leukemia (AML). The goal is to see if adding a new drug called tagraxofusp to two standard drugs helps elim…

This early-stage trial is testing a new cell therapy for children and adults whose leukemia has come back or persists after a donor stem cell transplant. Doctors take immune cells (T cells) from the original donor, genetically modify them to better recognize and attack the patien…

This study is testing whether adding a new oral drug, roginolisib, to two standard drugs (venetoclax and rituximab) is safe and works better for people with chronic lymphocytic leukemia (CLL) that has come back or stopped responding to treatment. About 64 participants will receiv…

This early-stage study is testing whether adding the drug mitoxantrone to a standard leukemia treatment can help patients whose cancer has returned or stopped responding. It will enroll about 30 adults with a specific type of acute myeloid leukemia. The main goals are to find a s…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing whether preventive antibiotics or immunoglobulin treatments work better to stop serious infections in people with blood cancers like leukemia, lymphoma, and myeloma. It will involve about 900 participants who have not yet started on immunoglobulin therapy. T…

This study aims to find the safest and most effective way to prevent serious infections in people with blood cancers like leukemia, lymphoma, and myeloma. Researchers are comparing two different prevention strategies: long-term antibiotics versus immunoglobulin replacement therap…

This trial aims to find the safest and most effective way to prevent serious infections in adults with blood cancers like myeloma, lymphoma, and leukemia. It will directly compare two common prevention strategies: immunoglobulin therapy and antibiotics. The goal is to see which a…

This study is testing if blood thinner pills (apixaban or rivaroxaban) are as safe and effective as standard daily shots (low-molecular-weight heparin) at preventing dangerous blood clots in people being treated for blood cancers like leukemia, lymphoma, or multiple myeloma. Abou…

This study is testing whether a long-acting antibiotic called dalbavancin, given every 28 days, can prevent serious bloodstream infections in children and young adults with high-risk leukemia who are receiving intense chemotherapy. The trial will enroll up to 29 participants to s…

This study is testing whether adding guided spiritual care sessions to standard hospital care can help adults with acute leukemia feel better during their treatment. Researchers will enroll 70 hospitalized patients and randomly assign them to receive either the special spiritual …

This study is testing a new hospice care program that provides blood transfusions at home for patients with advanced blood cancers. The goal is to see if this program improves patients' quality of life and mood, and helps more people choose hospice care, compared to the usual sta…

This study is testing whether a 12-week nutrition and exercise program is practical and helpful for people with myeloproliferative neoplasms (MPNs), a type of chronic blood cancer. Researchers want to see if patients can complete the program and if it improves their fatigue, anxi…

This study aims to understand the inherited genetic factors that cause lymphoma, leukemia, and related cancers within families. Researchers are recruiting individuals and their family members who have a personal or family history of these diseases. The main goal is to collect DNA…

This study aims to understand how air pollution causes serious diseases like lung cancer, COPD, and leukemia. Researchers will compare pollution levels found in the bodies of 300 non-smoking patients with these conditions to levels in healthy volunteers. The goal is to find new b…

This study aims to understand how whole brain radiation therapy affects memory, thinking, and quality of life in patients with blood cancers like lymphoma and leukemia. Researchers will follow 100 adult patients for up to 5 years, using standard memory tests, questionnaires, and …

This study aims to understand how stem cell transplants affect how patients process medications. Researchers will collect DNA samples from adults with blood cancers before and after transplant to determine the best source for genetic testing. The goal is to improve medication dos…

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study is testing a new tool called PRIME that helps older adults with blood cancers and their doctors discuss treatment priorities. It compares whether using this tool helps patients feel their final treatment decision better matches their personal values compared to standar…

This study aims to understand how a cancer drug called venetoclax works in the body when it's given as a liquid made from crushed tablets. It will enroll up to 30 children and young adults with blood cancers who are already receiving this liquid form because they cannot swallow p…

This study aims to understand how the services from the nonprofit Blood Cancer United affect people with blood cancers. Researchers will follow 400 patients for six months to see if the organization's help improves their access to medical care, quality of life, and financial stre…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand if exposure to hazardous chemicals during firefighting increases early signs that can lead to blood cancers. Researchers will enroll 300 Charlotte firefighters aged 40-49 with at least 5 years of experience to test their blood for these early markers…

This study is collecting and storing blood and tissue samples from patients with blood cancers like leukemia and lymphoma. The goal is to build a library of samples for researchers to study, which may help them better understand these diseases and develop new treatments in the fu…

This study is collecting information about how patients with blood cancers and disorders respond to stem cell transplants in the high-altitude Tibetan region. Researchers are enrolling 1000 patients and their donors to track treatment patterns, recovery times, survival rates, and…

This study aims to find inherited genetic changes that might make some families more likely to develop certain blood cancers, specifically acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Researchers will use advanced DNA sequencing technology to analyze blood an…

This study aims to gather detailed information on many different blood diseases in China, including cancers like leukemia and lymphoma, and conditions like hemophilia. It will follow 2,300 patients to learn how common these diseases are, what treatments patients receive, how well…

This study aims to understand and improve communication and support for Spanish-speaking families of children with leukemia or lymphoma. Researchers will interview families to learn about their experiences, needs, and the barriers they face in getting care. The goal is to gather …

This study aims to understand if CAR T-cell therapy, a powerful treatment for aggressive blood cancers, affects how children and young adults think, learn, and remember. Researchers will follow 60 participants aged 5-35 for up to 3 years, giving them regular thinking and memory t…

This study is a large registry that collects information on how adult patients with acute lymphoblastic leukemia (ALL) and related blood cancers are diagnosed and treated in real-world clinics. It aims to track patient outcomes, survival, and quality of life over time to help res…