LEUKEMIA

This early-phase trial tests whether specially trained natural killer (NK) cells can safely prevent blood cancers like leukemia from coming back after a stem cell transplant. About 15 adults with high-risk disease will receive an infusion of these cells plus a supportive drug. Th…

This study tests whether adding a new drug called roginolisib to two standard drugs (venetoclax and rituximab) is safe and works better for people with chronic lymphocytic leukemia (CLL) that has come back or not responded to prior treatments. About 64 adults who have already tri…

This study tests the safety and effectiveness of ponatinib in children aged 1 to under 18 with advanced leukemias, lymphomas, or solid tumors that have come back or not responded to other treatments. The goal is to see if the drug can shrink or control the cancer. About 70 childr…

This early-stage study tests a new drug called Karonudib in 9 adults with blood cancers like leukemia who have run out of standard treatments. The main goal is to check if the drug is safe and tolerable, and to find the right dose for future studies. Researchers will also look fo…

This study tests adding a new drug called capivasertib to a standard treatment for adults with certain types of leukemia or lymphoma that have come back or not responded to treatment. The standard treatment includes venetoclax and low-intensity chemotherapy. The study has three p…

This study tests a long-acting antibiotic called dalbavancin to prevent serious bloodstream infections in children and young adults with high-risk leukemia who are receiving strong chemotherapy. About 29 participants will receive the drug every 28 days. The goal is to see if it s…

This study tests whether a cord blood transplant, used as a first or second transplant, can help children and young adults (up to age 26) with blood cancers like leukemia and lymphoma. About 71 participants will receive the transplant to see if it keeps them cancer-free for at le…

This early-phase trial tests a new drug called revumenib alongside standard chemotherapy and a targeted therapy (midostaurin) for adults with a specific genetic form of acute myeloid leukemia (AML). The goal is to find a safe dose that improves remission rates. About 22 newly dia…

This early-phase study tests whether a new treatment called BiTE-EV is safe and can help adults with relapsed or treatment-resistant acute B-cell leukemia. Only 3 participants will receive the therapy every other day for 1-2 months, followed by regular checkups. The main goals ar…

This study tests whether the drug mosunetuzumab, given alone or with a BTK inhibitor (like ibrutinib), can clear tiny amounts of leftover leukemia cells in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who are already on or ha…

This early-phase study tests the safety of giving special immune cells (CIML NK cells) along with a standard drug (venetoclax) to adults with acute myeloid leukemia (AML) whose disease has come back or is hard to treat. Ten participants will receive the cell infusion after a shor…

This study looks at different ways to prevent serious infections in people with blood cancers like myeloma, leukemia, and lymphoma. About 900 participants who have been on immunoglobulin therapy for at least 6 months will either stop it, switch to antibiotics, or continue current…

This early-stage study tests the safety of a new drug called ziftomenib when combined with standard chemotherapy for people whose acute myeloid leukemia (AML) has returned or not responded to treatment. The study includes adults with specific genetic changes (NPM1 mutation or KMT…

This study tests a modified, lower-dose chemotherapy for adults with acute lymphoblastic leukemia who are too frail for standard treatment. The goal is to improve survival and reduce severe side effects. About 45 participants will receive an adjusted regimen designed to be better…

This study tests whether a new combination of three drugs (tagraxofusp, azacitidine, and venetoclax) can safely eliminate leftover leukemia cells that are not visible under a microscope in adults with acute myeloid leukemia (AML). These hidden cells can cause the cancer to come b…

This study tests a drug called revumenib in people with certain types of leukemia that have high levels of HOX genes. The goal is to see if the drug can help control the cancer. The trial is for 40 patients aged 12 and older whose leukemia has come back or not responded to other …

This study tests a new drug called MP0533 in about 249 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to treatment. The main goals are to find a safe dose and see if the drug can shrink or control the cancer. Partici…

This study tests two different doses of quizartinib as a maintenance therapy for adults with a specific type of acute myeloid leukemia (FLT3-ITD positive) who are in their first complete remission and have not had a stem cell transplant. The goal is to see which dose is safer and…

This study tests whether adding a special type of immune cell (memory T cells) after a donor stem cell transplant can help prevent serious viral and fungal infections. It involves up to 100 children and young adults with blood cancers or immune disorders. The approach aims to spe…

This early-stage study is testing whether combining two drugs, venetoclax and Vyxeos, is safe for children, teens, and young adults (ages 1 to 39) with acute leukemia that has come back or not responded to standard treatment. The main goal is to find the best dose with the fewest…

This study tests a new drug combination for adults with acute myeloid leukemia (AML) whose cancer did not respond to or came back after standard treatment. About 30 participants will receive mitoxantrone added to their current therapy to see if it can safely improve outcomes. The…

This study tests a combination of chemotherapy drugs (mini-Hyper-CVD) plus three targeted therapies (rituximab, inotuzumab ozogamicin, and blinatumomab) in children and young adults with B-cell acute lymphocytic leukemia that has come back or not responded to treatment. The goal …

This study tests whether adding the drug quizartinib to standard chemotherapy helps adults with a specific type of acute myeloid leukemia (AML) live longer. About 700 adults aged 18 to 70 with newly diagnosed FLT3-ITD negative AML will receive either quizartinib or a placebo alon…

This study tests different ways to prevent serious infections in people with blood cancers like myeloma, lymphoma, and leukemia. About 900 participants will receive either antibiotics or immunoglobulin therapy to see which approach works best. The goal is to reduce severe infecti…

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people with certain types of acute leukemia that have come back or not responded to treatment. The trial includes about 52 participants aged 12 and older with specific genetic changes in their le…

This early-phase study tests a new drug called CG009301 in adults with blood cancers (like leukemia or MDS) that returned or didn't respond to standard treatments. The main goals are to find a safe dose and check for side effects. About 45 participants will receive the drug until…

This study tests whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—is safe and effective for people with chronic lymphocytic leukemia (CLL) or Richter transformation (RT) who have not had prior treatment. About 60 adults will receive the drugs for a…

This study tests different ways to prevent serious infections in people with blood cancers like myeloma, lymphoma, and leukemia. About 900 participants will receive either antibiotics or immunoglobulin to see which approach works best. The goal is to reduce severe infections and …

This early-stage trial tests a new treatment for people with certain blood cancers (like Hodgkin lymphoma) that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells, which are modified in the lab to better attack cancer cells. The m…

This program provides stem cell transplants for up to 100 children and young adults with life-threatening blood disorders, such as leukemia or immune deficiencies, who do not have a matched sibling donor. The approach uses a special technique to remove certain immune cells from t…

This early-stage study tests a new treatment for children and adults with acute leukemia that has come back or not responded after a donor stem cell transplant. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack a protei…

This early-stage trial tests a new daily pill, BH-30236, for adults with acute myeloid leukemia (AML) or a high-risk pre-leukemia condition (MDS) that has returned or not responded to prior treatments. The study will first find the safest dose, then test it alone or with another …

This program provides access to a cancer treatment called tisagenlecleucel (Kymriah) for people with lymphoma, leukemia, or other conditions where standard treatments have failed. It is for patients who cannot join a clinical trial and have no other good options. The goal is to o…

This early-phase trial tests a new treatment called CD19 t-haNK for people with a type of blood cancer (B-cell acute lymphoblastic leukemia) that has come back after prior therapy. The treatment uses specially designed immune cells to attack cancer cells. Up to 10 participants wi…

This study tests whether a combination of three chemotherapy drugs (cladribine, low-dose cytarabine, and decitabine) can help control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) in patients aged 60 and older. Participants receive the drugs in cycles, …

This study looks at whether lower doses of two common blood thinner pills (apixaban and rivaroxaban) work as well as standard daily injections to prevent dangerous blood clots in people with blood cancers like lymphoma, leukemia, and multiple myeloma. About 100 participants will …

This study tests a combination of three drugs (cyclophosphamide, tacrolimus, and ruxolitinib) given after a stem cell transplant to prevent a serious complication called graft-versus-host disease (GVHD), where donor cells attack the patient's body. The trial involves 124 adults w…

This study tests a second type of CAR T-cell therapy (CD22 CAR T) for children and young adults whose B-cell leukemia came back after standard CD19 CAR T treatment. About 20 participants will receive the new cells 28 to 42 days after the first therapy. The main goals are to check…

This study looks at whether it is safe to stop antibiotics early in adults with high-risk blood cancers or those who have had stem cell or CAR T-cell therapy, once their fever has gone away. Many patients develop fever after treatment, but often no bacterial infection is found. T…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study compares two common treatments—immunoglobulin and antibiotics—to see which is better at preventing serious infections in people with blood cancers like myeloma, lymphoma, or leukemia. About 900 adults will take part. The goal is to find the safest and most effective wa…

This study tests whether a simple card game, called the Go Wish Game, can help people with advanced blood cancers or solid tumors talk about their end-of-life wishes with their doctors. About 75 adults with a life expectancy of more than 3 months will play the game and then compl…

This study tests whether 30 adults with myeloproliferative neoplasms (a type of blood disorder) can stick with a 12-week program that teaches healthy eating and physical activity. The main goal is to see if at least 70% of participants complete 9 weeks of the program. If successf…

This study looks at whether adding guided spiritual care sessions to standard hospital care is possible and helpful for adults with acute leukemia. About 70 participants will be randomly assigned to either receive these sessions or usual care. The goal is to see if patients accep…

This study looks at whether offering blood transfusions at home for people with advanced blood cancers who are in hospice care can improve their quality of life and mood. About 700 adults with relapsed or hard-to-treat blood cancers will take part. The goal is to see if this prog…

This study looks at whether adding a special palliative care program (called PEACE) to usual cancer care can help adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to either get PEACE plus standard …

This study is a registry that collects information from 1,000 patients with blood diseases who receive stem cell transplants at a hospital on the Qinghai-Tibet Plateau. Researchers will track their health, treatments, and costs over time to learn how high altitude affects recover…

This study tracks 300 firefighters aged 40-49 with at least 5 years on the job to see if exposure to hazardous compounds increases early signs of blood cancers. Researchers will test for pre-cancerous conditions like clonal hematopoiesis and monoclonal gammopathy. The goal is to …

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like lymphoma, leukemia, or multiple myeloma. The tool helps patients clarify their personal values and shares that information with their doctors. The goal is to see if using PR…

This study looks at whether using a simple early warning score (based on vital signs like heart rate and oxygen levels) can help doctors identify blood cancer patients who are getting sicker and need intensive care. The goal is to see if moving these patients to the ICU sooner ca…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study aims to uncover the genetic roots of lymphomas, leukemias, multiple myeloma, and similar diseases by collecting DNA and blood samples from people who have these conditions and their family members. Researchers will analyze the samples to find genes that increase the ri…

This study works with Spanish-speaking families who have a child with leukemia or lymphoma. Researchers will interview parents and patients to understand their experiences and find out how language barriers affect their care. The goal is to improve communication and build a stron…

This study aims to better understand chronic myelomonocytic leukemia (CMML), a rare blood cancer. Researchers will collect blood and bone marrow samples from 5,000 adults with CMML, taken during routine care or other clinical trials. The goal is to improve diagnosis, predict how …

This study tracks thinking and memory changes in children and young adults (ages 5-35) with hard-to-treat blood cancers who receive CAR T-cell therapy. Participants take computer and paper tests at home or at the hospital to measure memory, attention, and reasoning over up to 3 y…

This study collects blood, bone marrow, and tissue samples from up to 15,000 people with blood cancers or related disorders. The samples are stored and used for future research to better understand these diseases. Participants do not receive any treatment as part of this study. T…

This study follows 100 adults with blood cancers who receive whole brain radiation therapy to see how it affects their memory and thinking skills. Researchers will test cognitive function over time using standard assessments. The goal is to better understand the side effects of t…

This study is creating a large database of people in China with various blood diseases, such as leukemia, multiple myeloma, and hemophilia. Researchers will collect information from medical records and follow participants over time to learn about disease patterns, treatments, and…

This study is a large registry that gathers medical information and biological samples from 10,000 adults with acute lymphoblastic leukemia (ALL) and similar blood cancers. The goal is to learn how these diseases are diagnosed and treated in everyday practice, and to track patien…

This study is testing whether a specially designed video game can help young people (ages 15-39) who have had a stem cell transplant for leukemia or lymphoma improve their health habits. Researchers will collect feedback from 40 participants to see if the game is easy and enjoyab…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study aims to find gene changes that increase the risk of developing acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in families. Researchers will use advanced DNA sequencing to test both affected and healthy family members. The goal is to discover new or kn…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. T…

This study looks at how services from a non-profit cancer advocacy organization affect people with blood cancers like leukemia and lymphoma. Researchers will track 400 patients over time to see if the group's programs improve access to care, quality of life, and reduce financial …

This study enrolls 88 adults receiving a stem cell transplant for blood cancers. Researchers collect DNA from blood, skin, hair, and cheek cells before and after transplant to see which source gives the most reliable genetic information for adjusting drug doses. The goal is to im…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…