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New immune cell boost may shield kids from Post-Transplant infections

NCT ID NCT06839456

Recruiting now Disease control Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding memory immune cells (CD45RO) to a stem cell transplant can help children fight off dangerous viral and fungal infections after the procedure. The transplant uses donor stem cells that have been stripped of certain cells to prevent graft-versus-host disease, but this can leave the immune system weak. By adding back memory cells, researchers hope to speed up immune recovery without increasing the risk of graft-versus-host disease. The study involves 100 children and young adults up to age 25 with blood cancers, immune disorders, or bone marrow failure.

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Conditions

The condition(s) this trial relates to.

acquired aplastic anemia acute myeloid leukemia Bone Marrow Failure Disorders bone marrow failure syndrome Congenital Bone Marrow Failure Syndromes hemoglobinopathy hemophagocytic syndrome immunodeficiency disease inborn error of immunity inborn errors of metabolism inherited hemoglobinopathy leukemia myelodysplastic syndrome myelodysplastic syndrome with excess blasts non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACQUIRED APLASTIC ANEMIA BONE MARROW FAILURE HEMOGLOBINOPATHIES HIGH RISK ACUTE LYMPHOBLASTIC LEUKEMIA HIGH RISK ACUTE MYELOID LEUKEMIA HLH IMMUNODEFICIENCY INBORN ERRORS OF METABOLISM INHERITED BMF SYNDROME LEUKEMIA MDS (MYELODYSPLASTIC SYNDROME) PRIMARY IMMUNE REGULATORY DISORDER RELAPSE LEUKEMIA RELAPSED NON-HODGKIN LYMPHOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••