New stem cell transplant method aims to cut complications in young blood cancer patients

NCT ID NCT05794880

Recruiting now Disease control Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests a stem cell transplant method that removes specific immune cells (alpha/beta T cells and B cells) from the donor cells before transplant. The goal is to reduce the risk of graft-versus-host disease, a serious complication, while still allowing the transplant to work. Up to 40 children and young adults with various blood cancers will receive this treatment, and researchers will monitor engraftment, side effects, and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: stem cell transplant with T-cell and B-cell depletion using CliniMACS device
What this could lead to: If successful, this approach could reduce severe graft-versus-host disease and improve survival after stem cell transplants for blood cancers.
What could go wrong: This is a small, early pilot study with only 40 participants, so results may not apply broadly. Risks include infection, graft failure, or relapse of the cancer.

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Conditions

The condition(s) this trial relates to.

acute biphenotypic leukemia acute leukemia of ambiguous lineage acute lymphoblastic leukemia acute myeloid leukemia blast phase chronic myelogenous leukemia, BCR-ABL1 positive Burkitt lymphoma chronic myelogenous leukemia, BCR-ABL1 positive leukemia leukemia, myeloid, accelerated-phase Leukemia, Myeloid, Chronic-Phase lymphoblastic lymphoma lymphoma myelodysplastic syndrome myelodysplastic syndrome with excess blasts Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA IN REMISSION ACUTE MYELOID LEUKEMIA IN REMISSION BIPHENOTYPIC ACUTE LEUKEMIA BURKITT LEUKEMIA BURKITT LYMPHOMA CHRONIC MYELOGENOUS LEUKEMIA - CHRONIC PHASE CHRONIC MYELOGENOUS LEUKEMIA WITH CRISIS OF BLAST CELLS CHRONIC MYELOGENOUS LEUKEMIA, ACCELERATED PHASE LEUKEMIA LYMPHOBLASTIC LYMPHOMA LYMPHOMA AFTER RELAPSE MYELODYSPLASIA OTHER MALIGNANT HEMATOLOGIC DISEASES IN REMISSION

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Children's Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

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