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Ultrasound may reveal hidden bone damage in blood cancers

NCT ID NCT07785505

Diagnosis Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
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Registered, but not yet taking participants.
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Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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The trial has finished. Results may not be published yet.
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Cancelled before anyone took part.

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Approved
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When the status isn't known

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First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This study tests whether musculoskeletal ultrasound can reliably detect bone, joint, and soft-tissue problems in adults with blood cancers like leukemia, lymphoma, and multiple myeloma. Participants with symptoms such as bone pain, joint swelling, or muscle pain will receive a detailed ultrasound of the affected areas. The goal is to see what patterns of damage show up and how they relate to the type of cancer and lab results. If ultrasound proves accurate, it could offer a quick, radiation-free way to assess musculoskeletal involvement in these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Musculoskeletal ultrasonography (MSUS), a non-invasive imaging technique
What this could lead to
If successful, this could establish ultrasound as a reliable, radiation-free tool for detecting bone and joint involvement in blood cancer patients, potentially guiding faster and safer diagnosis.
What could go wrong
This is a small, early diagnostic study, so findings may not apply broadly. Ultrasound depends on operator skill, and results may not replace more definitive imaging like MRI or biopsy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients aged 18 years or older with a confirmed diagnosis of hematologic malignancy (leukemia, lymphoma, or multiple myeloma) established by bone marrow examination, histopathology, and/or immunophenotyping, identified through the Clinical Hematology Unit registry at Assiut University Hospital, who present with musculoskeletal symptoms and undergo musculoskeletal ultrasound evaluation.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (aged 18 years or older) with a confirmed diagnosis of hematologic malignancy (leukemia, lymphoma, or multiple myeloma) established by bone marrow examination, histopathology, and/or immunophenotyping. * Patients presenting with musculoskeletal symptoms and undergoing musculoskeletal ultrasonography for the assessment of musculoskeletal involvement at diagnosis or during follow-up. * Patients willing and able to provide written informed consent. Exclusion Criteria: * Patients with a prior or concurrent solid organ malignancy with known skeletal metastasis. * Patients with a history of major musculoskeletal trauma, orthopedic surgery, or active musculoskeletal infection affecting the examined region. * Patients with other connective tissue diseases (e.g., systemic lupus erythematosus, systemic sclerosis). * Patients with other inflammatory arthropathies (e.g., psoriatic arthritis, ankylosing spondylitis, reactive arthritis). * Patients with incomplete clinical, laboratory, or follow-up data. * Patients who decline to participate or withdraw consent.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm leukemia lymphoma musculoskeletal system disorder myeloid sarcoma plasma cell myeloma synovitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hematologic neoplasms Leukemia Lymphoma Multiple myeloma Musculoskeletal diseases

How to take part

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  1. The official record

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