MUSCULOSKELETAL DISEASES

This program provides access to an experimental drug, AOC 1044, for people with Duchenne muscular dystrophy (DMD) whose genetic mutation can be treated by skipping exon 44. The goal is to help control the disease and improve muscle function. Participants must be at least 2 years …

This study compares two types of wrist fusion surgery for people with post-traumatic wrist arthritis. One surgery fuses four wrist bones and removes the scaphoid. The other fuses three or two bones and also removes the triquetrum. The goal is to see which approach gives better gr…

This study aims to develop a faster and more consistent MRI method to detect early signs of osteoarthritis and other joint problems. Researchers will scan 88 healthy volunteers and patients with ACL tears using MRI machines from different manufacturers. The goal is to create a st…

This study compares two treatments for carpal tunnel syndrome: an ultrasound-guided injection around the nerve versus a small-incision surgery to relieve pressure. Researchers will measure pain and hand function in 60 adults with mild to severe symptoms over 12 weeks. The goal is…

This study tests a new treatment for heel pain caused by plantar fasciitis. Tiny, dissolvable beads are injected to block blood flow to the painful area. The goal is to see if this procedure safely reduces pain better than standard care. About 45 adults with chronic heel pain wil…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study surveys 90 dentists and dental specialists to find out how common muscle and bone pain is in their job. Participants fill out a questionnaire about pain in different body areas and their knowledge of ergonomics. The goal is to identify which body parts are most affecte…

This study looks at how carpal tunnel syndrome (CTS) severity relates to sleep quality. Researchers will compare 120 CTS patients with healthy controls using ultrasound and sleep questionnaires. The goal is to better understand the connection between nerve compression and poor sl…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study is an online survey for 1,000 adults diagnosed with a rheumatic or musculoskeletal disease living in a EULAR country. Participants will answer periodic questionnaires about their healthcare, social life, and work. The goal is to gather real-world data to help researche…