MUSCULOSKELETAL DISEASES

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

This study looked at whether high-intensity laser therapy can reduce shoulder pain and improve movement in people who have had a stroke. Forty participants aged 50-85 with lasting shoulder pain after a stroke received the laser treatment. The goal was to see if it helps with pain…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study aims to create a better way to help older adults with muscle, bone, or nerve problems who are at risk of falling. Researchers will first study patients' health profiles and balance, then test a simple exercise program called OTAGO to see if it prevents falls. The goal …

This study looked at whether a 6-month strength training program could improve bone health, sleep patterns, and quality of life in healthy adults aged 30 and older. 56 participants did specific exercises using equipment, and researchers measured changes in muscle mass, bone marke…

This study looked at 110 medical secretaries to see how their office setup, posture, and work organization relate to muscle and joint pain. Participants filled out questionnaires about their work environment and any discomfort. The goal is to find patterns that could lead to bett…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study tested a surgical navigation system called NextAR TKA that helps surgeons balance soft tissues during knee replacement. Forty adults scheduled for knee replacement with a specific implant were enrolled. The goal was to see if the system improves patient-reported outcom…

This study followed 225 people who had ACL reconstruction surgery to see how their knees were doing 10 years later. Researchers looked at X-rays and pain scores to find out which factors increase the risk of developing osteoarthritis. The goal is to better understand long-term ou…

This pilot study tested whether a very low carbohydrate ketogenic diet or a Mediterranean diet affects bone health and muscle function in older adults. Twelve postmenopausal adults followed each diet for six weeks. The goal was to see if these diets are safe and worth studying fu…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…