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New drug LEVI-04 aims to ease knee arthritis pain without opioids

NCT ID NCT05618782

Completed Symptom relief Sponsor: Levicept Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
LEVI-04 (a lab-made protein that blocks a pain signal)
What this could lead to
If it works, this could point toward a new non-opioid pain reliever for people with knee osteoarthritis.
What could go wrong
This is an early Phase 2 trial, so results may not hold up in larger studies. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease arthropathy musculoskeletal system disorder osteoarthritis osteoarthritis, knee Pain rheumatic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS JOINT DISEASES KNEE OSTEOARTHRITIS MUSCULOSKELETAL DISEASES OSTEO ARTHRITIS KNEE PAIN RHEUMATIC DISEASES

Contacts and locations

Locations

  • CCR Brno, s.r.o

    Brno, Czechia

  • CCR Czech a.s

    Pardubice, Czechia

  • CCR Prague, s.r.o

    Prague, Czechia

  • Hong Kong Center for Clinical Research

    Hong Kong, Hong Kong

  • Medyczne Centrum Hetmańska

    Poznan, Poland

  • NZOZ Bif-Med. s.c.

    Bytom, Poland

  • PMSI Cardiology Institute/RTL SM SRL Consultative ward

    Chisinau, Moldova

  • PMSI Clinical Republican Hospital "Timofei Mosneaga"

    Chisinau, Moldova

  • Sanos Clinic Herlev

    Herlev, Denmark

  • Sanos Clinic Nordjylland

    Gandrup, Denmark

  • Sanos Clinic Syddanmark

    Vejle, Denmark

  • Somed CR

    Lodz, Poland

  • Somed CR

    Warsaw, Poland

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