New drug LEVI-04 aims to ease knee arthritis pain without opioids
NCT ID NCT05618782
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LEVI-04 (a lab-made protein that blocks a pain signal)
What this could lead to
If it works, this could point toward a new non-opioid pain reliever for people with knee osteoarthritis.
What could go wrong
This is an early Phase 2 trial, so results may not hold up in larger studies. The drug may not work better than placebo, and side effects are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CCR Brno, s.r.o
Brno, Czechia
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CCR Czech a.s
Pardubice, Czechia
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CCR Prague, s.r.o
Prague, Czechia
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Hong Kong Center for Clinical Research
Hong Kong, Hong Kong
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Medyczne Centrum Hetmańska
Poznan, Poland
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NZOZ Bif-Med. s.c.
Bytom, Poland
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PMSI Cardiology Institute/RTL SM SRL Consultative ward
Chisinau, Moldova
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PMSI Clinical Republican Hospital "Timofei Mosneaga"
Chisinau, Moldova
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Sanos Clinic Herlev
Herlev, Denmark
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Sanos Clinic Nordjylland
Gandrup, Denmark
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Sanos Clinic Syddanmark
Vejle, Denmark
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Somed CR
Lodz, Poland
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Somed CR
Warsaw, Poland