OSTEO ARTHRITIS KNEE

This study checks if a surgical robot (ROSA Knee) can help surgeons make last-minute adjustments during total knee replacement. About 80 people with knee arthritis or rheumatoid arthritis will take part. The goal is to see if the robot's ability to change the bone cut plan during…

This study tests whether adding metformin, a diabetes drug, to standard care can reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 30 to 60 with moderate knee arthritis will take metformin or a placebo alongside their usual treatments. The …

This study compares two types of knee replacement surgery for people with advanced knee arthritis: a standard total knee replacement and a robotic-assisted partial knee replacement. The goal is to see which one gives better knee function and is more cost-effective. About 159 adul…

This study tests whether adding a therapy that involves breathing air with low and then high oxygen levels (intermittent hypoxia-hyperoxia) to standard physical therapy can better reduce pain and improve daily function in people with knee osteoarthritis. The trial will include 60…

This study looks at whether different types and doses of vitamin K can improve knee osteoarthritis in people aged 60 and older. Researchers will measure changes in blood markers linked to joint health. The goal is to find the best vitamin K form and dose for easing osteoarthritis…

This study is testing a device called the MISHA Knee System to see if it safely reduces pain and improves knee function in people with medial knee osteoarthritis. About 120 adults aged 25 to 65 who have not gotten relief from other treatments will receive the implant and be follo…

This study looks at whether adding a fall prevention program to regular physical therapy can reduce falls and improve balance in older women who have had a total knee replacement. About 90 participants will be followed for 24 weeks. The goal is to help seniors recover more safely…

This study compares two pain-relief methods after total knee replacement: a single shot of adductor canal block (ACB) versus a continuous femoral nerve block (FNB). The goal is to see which approach helps patients walk farther sooner after surgery. About 220 adults scheduled for …

This study tests whether using a whole-body vibration machine at home for 12 weeks can reduce knee pain and inflammation in people with osteoarthritis. Researchers will measure pain sensitivity, blood vessel function, and inflammation levels in 30 adults aged 40-75. The goal is t…

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and arthritis will receive one of the two injections and be followed for up to a year. The goal is to see if the hydrogel provid…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study tests a new treatment called OA-SYS for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and well-tolerated. Researchers will also check if it reduces pain and improves knee function. About 400 adults aged 35 to 75 will take par…

This study aims to see if a combination injection of platelet-rich plasma (PRP) and hyaluronic acid works better than either injection alone for knee osteoarthritis. It will involve 288 adults with knee pain who haven't gotten enough relief from standard treatments. Participants …