OSTEO ARTHRITIS KNEE

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This study tests whether a surgical robot (ROSA Knee) can help surgeons adjust their knee replacement plan during the operation based on the condition of the patient's soft tissues. About 80 adults with knee arthritis or rheumatoid arthritis will take part and be followed for 2 y…

This study compares two types of knee replacement surgery for people with advanced knee arthritis: a standard total knee replacement and a robotic-assisted partial knee replacement. The goal is to see which one leads to better knee function and is more cost-effective. About 159 a…

This study tests a new treatment called OA-SYS, made from cells taken from fat tissue, for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and tolerable. 400 adults aged 35-75 with knee arthritis will receive the treatment and be monitore…

This study tests whether using a whole-body vibration plate at home for 12 weeks can reduce knee pain and inflammation in adults aged 40-75 with osteoarthritis. Participants stand on the device for up to 20 minutes per session. Researchers will measure pain sensitivity, artery st…

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and moderate to severe arthritis will receive one of the two injections. The goal is to see if the hydrogel reduces pain, stiffn…

This study tests whether filling the bone gap with a synthetic putty (AttraX Putty) during knee realignment surgery can reduce pain in the first week after surgery. About 40 adults with knee osteoarthritis will be randomly assigned to get the putty or standard surgery without a g…

This study compares two pain-relief methods after total knee replacement: a single injection into the adductor canal versus a continuous nerve block in the thigh. The goal is to see which approach helps patients walk farther and recover faster without increasing fall risk. About …

This study is testing a device called the MISHA® Knee System to see if it safely relieves pain and improves function in people with medial knee osteoarthritis. About 120 adults aged 25 to 65 who have not gotten relief from other treatments will receive the implant and be followed…

This phase 3 trial is testing whether adding metformin, a diabetes drug, to standard pain relief (celecoxib) can reduce pain and improve knee function in people with knee osteoarthritis. The study will enroll 70 adults aged 30-60 with moderate knee arthritis. Researchers will mea…

This study tests whether a combination of platelet-rich plasma (PRP) and hyaluronic acid injections works better than either treatment alone for knee osteoarthritis. About 288 adults aged 40 to 75 with knee pain will receive one of three treatments. The goal is to see if the comb…

This study tests different types and doses of vitamin K in 55 adults aged 60 and older with knee osteoarthritis. Researchers want to see if vitamin K can improve knee health by measuring changes in blood markers. The goal is to find the best form and dose for future larger studie…

This study tests whether adding a fall prevention program to standard physical therapy can reduce falls and improve balance in older adults who have had a total knee replacement. About 90 women aged 60 and older will be followed for 24 weeks. The program includes guidance on avoi…

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…