Could a common diabetes drug ease knee arthritis pain?
NCT ID NCT06231758
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial is testing whether adding metformin, a diabetes drug, to standard pain relief (celecoxib) can reduce pain and improve knee function in people with knee osteoarthritis. The study will enroll 70 adults aged 30-60 with moderate knee arthritis. Researchers will measure pain changes using a standard pain scale and the WOMAC osteoarthritis index.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin (a diabetes drug) combined with Celecoxib (an anti-inflammatory painkiller)
What this could lead to
If it works, this could offer a new, affordable way to better manage knee osteoarthritis pain and slow joint damage.
What could go wrong
This is a small, early-phase trial with only 70 participants. Metformin is not proven for arthritis yet, and results may not apply to everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mostafa Bahaa
RECRUITINGDamietta, New Damietta, 34518, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••