Could a common diabetes drug ease knee arthritis pain?

NCT ID NCT06231758

Recruiting now Symptom relief Sponsor: Mostafa Bahaa Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial is testing whether adding metformin, a diabetes drug, to standard pain relief (celecoxib) can reduce pain and improve knee function in people with knee osteoarthritis. The study will enroll 70 adults aged 30-60 with moderate knee arthritis. Researchers will measure pain changes using a standard pain scale and the WOMAC osteoarthritis index.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin (a diabetes drug) combined with Celecoxib (an anti-inflammatory painkiller)
What this could lead to: If it works, this could offer a new, affordable way to better manage knee osteoarthritis pain and slow joint damage.
What could go wrong: This is a small, early-phase trial with only 70 participants. Metformin is not proven for arthritis yet, and results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEO ARTHRITIS KNEE

Contacts and locations

Locations

Mostafa Bahaa
RECRUITING

Damietta, New Damietta, 34518, Egypt

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