Blocking knee blood vessels may offer new pain relief for severe osteoarthritis

This trial tests whether genicular artery embolization (GAE), a procedure that blocks certain blood vessels in the knee, can reduce persistent pain in people with severe knee osteoarthritis who haven't found relief from conservative treatments and may not be candidates for surgery. Participants are randomly assigned to either GAE or continued conservative care, and their pain and function are measured before treatment and at 6 weeks, 3 months, and 6 months after. The goal is to see if GAE can provide a meaningful reduction in pain and improvement in knee function.