Osteoarthritis

This trial tests whether a smartphone app-guided rehabilitation program (MOKneeTOR) is as effective as traditional hospital-based physiotherapy for people with knee osteoarthritis. Participants will be randomly assigned to either use the app for 24 weeks or attend outpatient phys…

This trial tests whether adding motivational interviewing—a counseling style that strengthens personal motivation—to a standard exercise program helps people with knee osteoarthritis feel more confident about exercising and managing pain. About 56 participants will be randomly as…

This study is testing a shoulder replacement device in 300 people with shoulder arthritis, bone death, or rotator cuff tears. Participants receive the implant and are followed for 10 years to see how well it works and if it is safe. The goal is to improve pain and shoulder functi…

This trial tests whether a new type of hip resurfacing implant, called the H1, can be as successful as a standard total hip replacement for people with hip arthritis. Participants will receive either the H1 implant or a traditional replacement, and researchers will compare their …

This trial investigates different types of steroid injections for back, neck, and related pain to see which are most effective and safe. It compares various steroids, doses, and injection sites, including epidural and facet joint injections. The study measures pain relief and fun…

This study follows 300 people with a specific type of knee injury called a displaced bucket-handle meniscus tear, which can lock the knee and damage the joint. Researchers will compare two surgical approaches: repairing the torn meniscus with stitches versus removing the damaged …

This study follows 60 adults who receive a total shoulder replacement using the PRIMA humeral stem, either in an anatomic or reverse configuration. The goal is to measure changes in shoulder function, pain, and quality of life over 24 months, as well as how well the implant holds…

This study tests whether taking oral tranexamic acid for three days after hip replacement surgery can reduce pain, swelling, and help patients walk sooner. About 101 adults with end-stage osteoarthritis will receive the drug or placebo. The goal is to see if this simple pill impr…

This study tests an experimental stem cell injection called FURESTEM-OA-Kit in people with knee osteoarthritis who previously received a placebo in an earlier trial. The goal is to see if the injection is safe and can improve knee pain, stiffness, and function. Participants will …

This study is testing the LEGION Medial Stabilized knee implant in 144 people who need total knee replacement due to arthritis or joint damage. The goal is to see how well the implant holds up over 10 years without needing revision surgery. Participants will receive one of three …

This Phase 3 trial tests whether a gel made from donated umbilical cord stem cells (CARTISTEM) can reduce pain and improve knee function better than a simple surgical cleanup (debridement) in people with knee cartilage damage and osteoarthritis. About 300 adults aged 18-75 with m…

This trial compares three common surgical procedures for thumb basal joint arthritis: trapeziectomy with ligament reconstruction, trapeziectomy with suture suspensionplasty, and arthroscopic trapeziectomy alone. The goal is to see which technique best restores grip and pinch stre…

This trial tests whether injections of platelet-rich plasma (PRP) — a concentrate from a person's own blood — can repair knee osteoarthritis and injuries to cartilage, meniscus, and ligaments. Researchers will compare PRP against standard hyaluronic acid injections in 300 adults …

This study looks at the safety and performance of the Incompass Total Ankle System, a device already approved by the FDA and used in ankle replacement surgeries. Researchers will follow 200 adults aged 21 and older who need ankle replacement due to arthritis or injury. The goal i…

This study tests a program that uses artificial intelligence to guide exercise and continuous glucose monitors to help people with both knee osteoarthritis and obesity. The goal is to see if it can improve blood sugar control, reduce knee pain, and lower the need for knee replace…

This trial tests two ways of aligning a new knee joint during robotic surgery: the traditional mechanical alignment that keeps the leg straight, and a personalized kinematic alignment that matches the patient's natural anatomy. Researchers will track how well the implant stays in…

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This trial investigates whether adding antibiotics (vancomycin and tobramycin) to bone graft material during hip replacement surgery can reduce the risk of serious joint infections. The study includes adults undergoing hip replacement who need bone graft, comparing those who rece…

This study tests a new implant called KeriFuse for fusing the last joint of fingers damaged by osteoarthritis. The implant is a staple made of a special metal that returns to its original shape after being placed, which may help the bone heal faster. About 50 adults with painful …

This study tests whether a lab-grown sheet of human cartilage cells (CLS2901C) can improve knee function and reduce pain in people with knee osteoarthritis. About 96 adults aged 20–79 who need knee realignment surgery will receive either the cell sheet plus surgery or surgery alo…

This trial tests a new partial knee implant called BioPoly for people with knee cartilage damage and pain. Participants are randomly assigned to receive either the implant or standard surgery (microfracture or debridement). The study measures success by pain and function improvem…

This study looks at how well a specific hip implant (CoCrMo LOCK bipolar femoral head) works for people who have had a hip fracture. Researchers will check how many patients need a second surgery or experience complications like dislocation within two years. The study includes 60…

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This study compares two types of partial knee replacements for people with arthritis on the inner side of the knee. One implant has a fixed bearing (the plastic piece stays still), while the other has a mobile bearing (the plastic piece can move slightly). Researchers will track …

This study compares a new plastic (PEEK) knee implant to a standard metal one in 200 people with severe knee osteoarthritis who need total knee replacement. The goal is to see if the plastic implant works just as well as metal in terms of pain relief, movement, and safety. Partic…

This study is a registry that will follow 300 people who receive the Freedom Total Knee System, a new artificial knee implant. The goal is to see how well the device holds up over time and how safe it is. Participants are adults with severe knee arthritis who have not gotten reli…

This study compares two surgical treatments for thumb base osteoarthritis: total joint replacement with the TOUCH prosthesis and trapeziectomy (removing a bone at the thumb base). Researchers want to see if joint replacement provides better grip strength and fewer complications. …

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. Seventy participants will be randomly assigned to receive either real-time biof…

This study tests whether a 20-day fasting schedule before hip replacement surgery can reduce complications like infections. 130 adults will either follow the fasting plan or receive standard care. Researchers will measure changes in gut bacteria and immune markers to see if fasti…

This study tests whether removing a small part of the shoulder bone (coracoid) during reverse total shoulder replacement helps patients rotate their arm inward better after surgery. Sixty adults needing shoulder replacement will be randomly assigned to get the standard surgery or…

This trial investigates whether montelukast, a common asthma medication, can reduce inflammation and prevent cartilage breakdown after anterior cruciate ligament (ACL) reconstruction. The study enrolls adults aged 25 to 50 who also have a meniscus tear, a group at high risk for r…

This phase II trial tests whether an implant made from a patient's own nasal cartilage can treat patellofemoral osteoarthritis (knee arthritis) better than standard platelet-rich plasma injections. 75 adults aged 18–65 with moderate knee arthritis will be randomly assigned to rec…

This study tests whether Mobithron Advance, a daily oral supplement made from undenatured type II collagen, can slow or reverse cartilage loss in people with knee osteoarthritis. Over 12 months, 84 participants will take either the supplement or a placebo. Researchers will use MR…

This study follows 50 people who receive a Zimmer Biomet shoulder replacement implant to see if it safely improves pain, movement, and quality of life over two years. Participants have shoulder arthritis, fractures, or other joint damage. The main goal is to measure a meaningful …

This study is testing a thumb joint replacement called the TOUCH CMC 1 Prosthesis in people with thumb arthritis. The goal is to see if it reduces pain and improves hand function. About 163 adults with moderate thumb arthritis will receive the implant and be followed for safety a…

This study compares two types of knee implants (medial congruent vs. posterior stabilized) in people having total knee replacement for arthritis. All surgeries will be done with the ROSA robotic system. Researchers will track 200 participants for up to 5 years to see which implan…

This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to r…

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifesty…

This study compares two types of shoulder replacement surgery for people aged 65-85 with shoulder arthritis. The goal is to see if a newer type of replacement (reverse shoulder) works as well as the standard one. Participants will be randomly assigned to one surgery and followed …

This study looks at how well a short, bone-friendly stem works for total hip replacement when done through a front-of-hip incision. Researchers will follow 400 adults with hip arthritis for at least two years to check implant survival, complications, pain, and recovery. The goal …

This study looks at whether repairing the shoulder capsule during a common stabilization surgery (Latarjet) can lower the chance of developing arthritis later. About 86 adults with shoulder instability will be randomly assigned to get capsule repair or not, then followed for up t…

This study is testing a new knee implant (Univation XF Pro) in 150 people with knee arthritis. The goal is to see how well the implant works and how safe it is over several years. Participants will have their knee function, pain, and quality of life tracked using questionnaires a…

This study tests a new way to repair damaged knee cartilage. Doctors take stem cells from the patient's bone marrow, grow them into cartilage in the lab, and then implant it into the knee. The trial includes 30 adults aged 18 to 65 with cartilage injuries or early knee osteoarthr…

This study compares two types of knee surgery for people with bow-legged knees and a torn meniscus. One surgery uses a newer bone-cut method, while the other uses a standard bone-cut method. About 20 participants will be randomly assigned to one of the two surgeries. Researchers …

This pilot study is testing a custom-made, 3D-printed titanium implant that replaces the ankle joint and talus bone in people with severe bone loss or damage. The implant is designed to fit each patient perfectly and aims to preserve ankle function while reducing surgical harm to…

This study follows over 1,000 people who receive a shoulder replacement with FX Shoulder Solutions systems. Researchers will track how often the implant needs to be replaced (revision) and measure pain, movement, and quality of life for up to 10 years after surgery. The goal is t…

This study tests whether injecting N-acetylcysteine (NAC), an antioxidant, into the ankle right after a severe pilon fracture can keep cartilage cells alive and reduce the chance of developing post-traumatic arthritis. Thirty adults with closed high-energy pilon fractures will re…

This study tests whether applying tranexamic acid directly into the surgical wound, in addition to giving it through an IV, can reduce bleeding and the need for blood transfusions in adults having extensive spine surgery. About 100 adults aged 18 to 80 with spinal deformity will …

This study tests a single injection of StromaForte, made from donor bone marrow cells, against a standard hyaluronic acid injection for knee osteoarthritis. About 140 adults with knee arthritis will receive one treatment and be followed for 12 months. The main goal is to see if S…

This Phase 2 trial tests whether a single injection of stem cells from umbilical cords can help people with knee osteoarthritis. 100 adults aged 40-70 will receive either a low or high dose of stem cells or a placebo. The study measures changes in pain, stiffness, and function ov…

This study is testing a new synthetic implant for the big toe joint in people with arthritis. The implant replaces the damaged joint surface to reduce pain and improve function. About 20 adults aged 21-75 with moderate to severe arthritis will be enrolled and followed for safety …

This study tests whether a surgical robot (ROSA Knee) can help surgeons adjust their knee replacement plan during the operation based on the condition of the patient's soft tissues. About 80 adults with knee arthritis or rheumatoid arthritis will take part and be followed for 2 y…

This study compares the usual surgery for thumb arthritis to a newer procedure that implants donated tissue at the base of the thumb. Researchers will track hand function and pain in 200 adults for one year after surgery. The goal is to see if the new approach leads to better rec…

This study compares two types of glenoid implants used in total shoulder replacement for patients with shoulder osteoarthritis. Half of the 94 participants will receive a standard cemented plastic implant, while the other half will receive a new hybrid implant with a titanium cen…

This study compares two methods of aligning a new knee joint during total knee replacement surgery: kinematic alignment and mechanical alignment. Researchers want to see which method gives better function and movement one year after surgery. The trial will involve 100 adults with…

This study follows 368 adults who need a partial hip replacement (hemiarthroplasty) due to fractures, arthritis, or bone death. Researchers will check how well Corin hip devices work and how safe they are over 10 years. The goal is to see if patients can move better and have fewe…

This study compares a robot-assisted system (CORI) to conventional manual instruments for total knee replacement. About 140 participants will be randomly assigned to one of the two methods. The main goal is to see if the robot helps achieve more precise leg alignment after surger…

This study is testing special screws that dissolve over time, used in foot and ankle surgeries for fractures, realignments, or joint fusions. The screws are meant to hold bones together while they heal, then safely absorb into the body. Researchers will follow 125 adults for 4 ye…

This study tests whether applying Prontosan antimicrobial gel to the skin during shoulder replacement surgery can reduce bacteria that might cause infections. It involves 60 adult men having their first shoulder replacement. Researchers will compare infection-related bacteria lev…

This study tests a 12-week digital exercise program for people who had ACL knee surgery. The program uses sensors to help correct how the knee moves during walking, with the goal of reducing joint inflammation and preventing osteoarthritis. Researchers will enroll 60 adults aged …

This study compares a new sensorimotor ankle rehabilitation training (SMART) program to standard care for people with a first-time ankle sprain. The goal is to see if SMART reduces re-injury rates and improves quality of life over one year. Researchers will enroll 150 participant…

This study tests whether a single injection of cells from your own bone marrow or belly fat can better ease knee osteoarthritis pain and stiffness. 204 adults aged 40-75 with knee OA will be randomly assigned to one of the two treatments. The goal is to see which cell source work…

This study compares two types of robotic-arm assisted knee replacement surgery in 120 people with knee osteoarthritis. One group gets cementless implants, the other gets cemented implants. The main goal is to see which approach helps patients 'forget' they have an artificial knee…

This study tests the safety of injecting a patient's own stem cells (from fat tissue) into the thumb joint to treat painful thumb arthritis when standard treatments have failed. The goal is to see if this injection can control the disease and avoid the need for surgery. The trial…

This study tests whether a platelet-rich plasma (PRP) injection, given soon after an ACL knee injury, can reduce inflammation and improve knee function. About 56 people with a recent ACL tear will receive either PRP or a placebo. The goal is to see if this treatment can lower the…

This study will follow 600 people who receive an FX artificial shoulder implant for conditions like arthritis, rotator cuff problems, or shoulder fractures. Researchers will measure pain, shoulder function, implant survival, and any complications over time. The goal is to see how…

This study compares two types of knee replacement surgery for people with advanced knee arthritis: a standard total knee replacement and a robotic-assisted partial knee replacement. The goal is to see which one leads to better knee function and is more cost-effective. About 159 a…

This study follows 150 people with knee osteoarthritis and leg misalignment who had a knee osteotomy—a surgery that realigns the bones to take pressure off the damaged part of the knee. Researchers want to see how well the knee works years later and whether this surgery can help …

This Phase 3 trial tests whether injections of amniotic suspension allograft (ASA) can reduce pain and improve function in people with knee osteoarthritis. 160 participants will receive either ASA, hyaluronic acid, or a saline placebo. Researchers will track pain, knee function, …

This study is testing a new type of knee implant that doesn't require bone cement, in 130 people needing total knee replacement. The goal is to see if the implant improves knee function, reduces pain, and helps patients feel more natural after surgery. Researchers will track outc…

This study follows 49 people who are getting a total hip replacement with a special device called the DELTA Revision cup. The goal is to see how safe and effective the implant is by measuring hip function, movement, and survival of the implant over two years. Participants are adu…

This study compares two types of hip implants used in total hip replacement surgery: one with a collar and one without. The goal is to see if the collared design reduces implant sinking and lowers the risk of bone fractures around the implant. About 100 adults getting a first-tim…

This study compares a new ceramic-coated hip implant to a standard plastic one in 100 people with hip arthritis. The goal is to see which implant causes fewer metal particles to enter the blood and which one helps patients move better over three years. Participants will be random…

This study tests an experimental drug called BT-114143 to see if it can reduce blood loss during knee replacement surgery better than a standard treatment. About 270 adults with osteoarthritis who need a knee replacement will take part. Participants will receive either a high or …

This study is testing a new hip replacement system called Emphasys Hip Solutions in 30 people with hip osteoarthritis. Researchers will use special X-ray imaging to see how well the implant stays in place over two years. The goal is to make sure the implant is stable and works we…

This study tests a new device called the LIFT Implant for people with kneecap arthritis. The implant lifts the kneecap tendon to reduce pressure on worn-out cartilage. Researchers will compare it to a standard surgery that moves a piece of shinbone. 245 adults aged 22 to 65 with …

This study compares two types of hip replacement materials in 100 adults aged 18 to 65 who need a total hip replacement. One group gets a ceramic-on-polyethylene implant where the polyethylene is infused with vitamin E to reduce wear. The other group gets a standard ceramic-on-ce…

This study tests whether stem cells from umbilical cords can help people with knee osteoarthritis. Sixty participants will receive either a low or high dose of these cells injected into the knee joint. The goal is to see if the treatment is safe and can reduce pain and improve kn…

This study tests whether injecting a patient's own fat tissue along with hyaluronic acid into one knee works better than fat alone in the other knee. One hundred adults with painful knee osteoarthritis will receive both treatments, and researchers will compare pain, stiffness, an…

This study compares two knee surgeries for people with knee osteoarthritis, a meniscus problem, and a misaligned leg. Half the participants will get a standard realignment surgery, and the other half will get that plus a donor meniscus transplant. The goal is to see if the combin…

This study is developing an artificial intelligence platform to analyze knee ultrasound images and predict outcomes after ultrasound-guided injections for degenerative knee disorders like osteoarthritis. Researchers will first train the AI to identify normal and abnormal knee str…

This study tests a portable ultrasound system to measure the position of the shoulder blade (scapula) in patients with shoulder arthritis while they stand. The goal is to see if this non-radiation method can give results similar to CT scans taken when lying down. Thirty adults sc…

This study is testing whether a smartphone app can detect early knee osteoarthritis by measuring how the knee moves during simple activities like walking. Researchers will compare the app's results to standard motion-capture equipment and patient symptoms. If it works, this could…

This study aims to find blood-based biomarkers that can diagnose osteoarthritis (OA) earlier than current methods. Researchers will collect blood samples from 300 people aged 40-70 with joint pain to test previously identified candidate markers. The goal is to develop a simple, r…

This study is testing an artificial intelligence system that reads medical images like X-rays and MRIs to diagnose and stage osteoporosis and osteoarthritis. Researchers aim to make diagnosis more accurate and consistent. The trial will enroll 2,000 adults who have already had im…

This study tests a modified MRI technique designed to reduce image distortion caused by metal hip implants. Researchers will compare standard and modified scans in 22 adults with hip replacements to see if the new method provides clearer pictures of nearby tissues. The goal is to…

This study compares SPECT-CT and MRI scans to see which is better at diagnosing symptomatic osteoarthritis in the ankle, hindfoot, and midfoot. Researchers will enroll 132 adults with suspected foot arthritis and measure each scan's accuracy. The goal is to determine the most rel…

This study aims to develop a faster and more consistent MRI method to detect early signs of osteoarthritis and other joint problems. Researchers will scan 88 healthy volunteers and patients with ACL tears using MRI machines from different manufacturers. The goal is to create a st…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This trial tests whether a 48-month program of dietary weight loss, exercise, and weight maintenance can prevent knee osteoarthritis in women aged 50 and older who have obesity and no or infrequent knee pain. Participants are randomly assigned to the diet-and-exercise program or …

This study tests whether tranexamic acid (TXA), a drug that reduces bleeding, can lower inflammation and protect joint health after an ACL tear. Fifty people aged 18-30 with a recent ACL injury will receive either TXA or a placebo around the time of surgery. The goal is to see if…

This study tests whether injecting a drug called anakinra into the knee within two weeks of an ACL injury can prevent arthritis that often develops years later. Half of the 32 participants will receive the drug, and half will receive a placebo (salt water). Researchers will track…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This study compares injections of a patient's own processed fat tissue (MFAT) against standard steroid shots for shoulder osteoarthritis. Researchers will track pain, function, and quality of life in 48 adults aged 25-75. The goal is to see if the fat injection provides better or…

This trial tests whether a brief course of savoring meditation—a practice that generates positive emotions—can reduce pain and improve reward system function in people undergoing knee replacement for osteoarthritis. Half of the 150 participants will receive this meditation traini…

This early-stage study tests a drug called CX-011 for moderate to severe knee osteoarthritis pain. About 72 adults aged 18-75 with knee osteoarthritis will receive the drug via injection into the knee joint. The main goals are to check safety and tolerability, and to see if it re…

This study compares two robot-assisted knee replacement methods for people with severe knee arthritis. One method uses a CT scan to plan the surgery (image-based), while the other uses a simpler approach without a scan (imageless). The goal is to see if the imageless method works…

This trial tests whether genicular artery embolization (GAE), a procedure that blocks certain blood vessels in the knee, can reduce persistent pain in people with severe knee osteoarthritis who haven't found relief from conservative treatments and may not be candidates for surger…

This trial tests whether adding a structured patient education program to standard physical therapy helps people with chronic low back pain, knee osteoarthritis, or shoulder pain stick to their prescribed home exercises. Participants will be randomly assigned to receive either st…

This study tests whether the antidepressant duloxetine can help reduce opioid painkiller use after knee replacement surgery. About 150 adults with knee osteoarthritis will receive either duloxetine or a placebo before and after surgery. The goal is to see if duloxetine lowers opi…

This study investigates whether a low-carbohydrate diet can reduce pain and improve quality of life in adults with knee osteoarthritis, compared to a standard USDA-recommended diet. Participants will follow a 6-week diet plan with all meals provided, and researchers will measure …

This study compares two minimally invasive procedures—cryoneurolysis (freezing nerves) and radiofrequency (using electric pulses)—to relieve knee pain in adults with osteoarthritis who haven't responded to standard treatments like painkillers or physical therapy. Sixty participan…

This trial asks whether mirogabalin or pregabalin provides better pain relief after total knee replacement surgery. Adults aged 50-85 with knee osteoarthritis will take one of the two drugs for two weeks after surgery. Researchers will measure pain scores, morphine use, and knee …

This study tests whether improving sleep before total knee replacement surgery can reduce pain after the operation. Adults aged 60 and older with knee osteoarthritis and sleep difficulties will receive either cognitive-behavioral therapy for insomnia, bright light therapy, or a c…

This trial tests whether eccentric strengthening exercises or low-load blood flow restriction training can improve muscle function, strength, and daily mobility in people with knee osteoarthritis. Participants aged 40 to 70 with mild to moderate knee arthritis will follow a four-…

This Phase 2 trial tests a single injection of a gene therapy called PCRX-201 in 135 adults aged 45–80 with painful knee osteoarthritis. Participants receive one of two doses or a placebo, then are monitored for safety and pain relief over 5 years. The goal is to see if the injec…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This study is testing whether giving a steroid injection to the knee that is not being operated on can help reduce pain and improve function for people undergoing total knee replacement. The study will involve 60 adults with knee osteoarthritis who are scheduled for a single knee…

This trial tests whether pressure biofeedback training—using a device that shows how hard you press—can reduce pain and improve muscle function better than bolster foam rolling in people with knee osteoarthritis. Forty-eight participants with moderate knee arthritis will do one o…

This study tests whether a specific nerve block, called FRONT, can help people recover better after total hip replacement surgery. 80 adults having hip replacement will be randomly assigned to receive either the FRONT block or standard pain medication. The main goal is to see if …

This trial tests whether a nerve-blocking procedure called genicular nerve radiofrequency ablation, done two to six weeks before total knee replacement, can reduce postoperative pain and improve function. The study includes adults aged 18 to 60 who are scheduled for knee replacem…

This study tests different types and doses of vitamin K in 55 adults aged 60 and older with knee osteoarthritis. Researchers want to see if vitamin K can improve knee health by measuring changes in blood markers. The goal is to find the best form and dose for future larger studie…

This study tests whether auriculotherapy (ear acupuncture) can reduce pain after outpatient surgery for thumb arthritis. Sixty adults undergoing endoscopic thumb surgery will receive either real or sham ear acupuncture. Pain levels will be measured from day 1 to day 3 after surge…

This trial compares two types of nerve blocks for pain control after bilateral total knee replacement. One combines a standard numbing medication with two steroids, the other uses a long-acting liposomal bupivacaine. Researchers want to see if the steroid-enhanced block provides …

This phase 2 trial tests whether a nerve block containing bupivacaine plus two steroids (dexamethasone and methylprednisolone) can provide better pain relief after total knee replacement than the standard combination of bupivacaine and liposomal bupivacaine (Exparel). About 250 a…

This study tests whether a supplement called MyCondro can help people with knee osteoarthritis move better and feel less joint discomfort. Researchers will give two different doses to 240 adults aged 45 and older who have had knee problems for at least six months. The main goal i…

This trial compares three regional anesthesia techniques after total knee replacement to see which one helps patients regain knee movement best. Adults scheduled for knee replacement will be randomly assigned to one of three groups: spinal anesthesia with an epidural, a nerve blo…

This study looks at whether adding trunk (core) stabilization exercises to standard physical therapy can reduce knee pain and improve daily function in people with knee osteoarthritis who also have back pain (knee-spine syndrome). About 70 adults aged 40-60 with moderate knee art…

This study investigates whether low-dose radiation therapy (LDRT) can reduce pain and improve function in people with osteoarthritis of the hips, knees, hands, shoulders, ankles, or elbows. Participants who have not responded to standard treatments will receive one or two courses…

This study compares two types of physical therapy for knee osteoarthritis: one done in a pool and one on land. Sixty-six adults aged 40-65 with knee osteoarthritis will receive either aquatic or land-based mobilization therapy for four weeks. Researchers will measure pain, stiffn…

This study compares two ways to restrict blood flow during exercise—using a special floss band or a traditional cuff—to see which better reduces pain and improves movement in people with knee osteoarthritis. 46 adults aged 40-60 with mild to moderate knee OA will do leg exercises…

This study tests two types of leg exercises—closed chain (like mini-squats) and open chain (like leg lifts)—both done with a blood flow restriction cuff on the thigh, in people with mild knee osteoarthritis. Forty participants aged 45-75 will do these exercises plus standard phys…

This study investigates whether combining a gentle mind-body exercise called Baduanjin with a non-invasive brain stimulation technique (tDCS) can help relieve pain and improve brain function in people with knee osteoarthritis. Researchers will use brain scans to see how these tre…

This study looks at whether drinking a daily whole food plant-based smoothie for two weeks before revision knee replacement surgery can lower inflammation and pain afterward. Twenty-four adults scheduled for surgery will either add the smoothie to their diet or make no changes. R…

This study tests a digital rehabilitation program for people with knee osteoarthritis and healthy older adults. It uses a smart knee brace with sensors, electrical stimulation, and AI to guide exercises at home. The goal is to see if this approach improves pain, muscle strength, …

This study looks at whether adding a targeted nerve treatment to a standard procedure can better relieve chronic knee pain from osteoarthritis. Researchers are comparing standard radiofrequency treatment alone versus standard treatment plus pulsed radiofrequency on specific senso…

This study tests two non-drug treatments for knee osteoarthritis: weighted dangling exercises (gravity-assisted leg swings with ankle weights) and neuromuscular electrical stimulation targeting a key thigh muscle. Researchers will compare how well each approach reduces pain and i…

This study is testing a device called the MISHA® Knee System to see if it safely relieves pain and improves function in people with medial knee osteoarthritis. About 120 adults aged 25 to 65 who have not gotten relief from other treatments will receive the implant and be followed…

This study tests a procedure called Genicular Artery Embolization for people with mild-to-moderate knee osteoarthritis. Doctors inject tiny particles into arteries that supply the knee lining to reduce blood flow and hopefully ease pain. Fifteen participants will be followed for …

This study tests whether an artificial intelligence-assisted educational video can reduce kinesiophobia (fear of movement) and improve readiness for hospital discharge in people undergoing total knee replacement. Half of the 72 participants will watch the AI video before their fi…

This study compares three methods to reduce pain during corticosteroid injections for arthritis, tendinopathy, or nerve compression in the hand, wrist, or elbow: no anesthesia, a vibrating device, or a cooling spray. Each participant will receive two of the three methods to see w…

This study tests whether a magnesium supplement called Magnesium-L-Threonate (MgT) can improve sleep quality and reduce pain in people recovering from total knee or hip replacement. Researchers will enroll 64 adults having surgery at the University of Miami Hospital. Participants…

This Phase 3 trial tests whether a once-weekly injection called NNC0487-0111 can help people with overweight or obesity and knee osteoarthritis lose weight and feel less pain. About 400 adults will receive either the drug or a placebo for several weeks. Researchers will measure c…

This study tests whether a short course of the steroid methylprednisolone, taken as pills after knee replacement surgery, can reduce pain, opioid use, and nausea. About 420 adults having knee replacement for osteoarthritis will receive either the steroid or a placebo. The goal is…

This study tests whether a 30-minute virtual reality session with nature scenes and music can reduce pain, anxiety, and improve comfort in people who just had hip replacement surgery. Participants choose from forest, beach, underwater, or outdoor footage. The goal is to see if VR…

This study tests whether a 5-minute guided breathing technique called box breathing can help older adults (65+) manage stress and recover better after total knee replacement. Thirty-two participants will be randomly assigned to either the breathing exercise or a control activity.…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can improve pain and depression in people with knee osteoarthritis. Thirty adults aged 50 and older with chronic knee pain and moderate to severe depression will receive rTMS while also ta…

This study tests whether giving dexamethasone through a vein can improve pain control after total hip replacement. About 198 adults having hip surgery will receive either no dexamethasone, 4 mg, or 8 mg, along with standard anesthesia and a nerve block. The main goal is to see ho…

This study tests whether injecting ozone gas into the knee joint, combined with exercise, can reduce pain and improve function in people aged 40-75 with moderate knee osteoarthritis. Participants receive three weekly ozone injections at different concentrations (10, 15, or 20 µg/…

This study will compare three pain management methods after hip surgery in 108 adults aged 65 and older. The methods are a nerve block (PENG block), a local anesthetic injection around the joint (periarticular injection), or both combined. The goal is to see which approach reduce…

This study tests whether a numbing injection called a PENG block can reduce inflammation and pain in older adults having hip replacement surgery. Sixty patients will receive either the numbing drug ropivacaine or a placebo (salt water) after spinal anesthesia. The goal is to see …

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Resear…

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study compares two types of nerve blocks to see which provides better pain relief after total hip replacement. Fifty adults having hip surgery will receive one of the two blocks. Researchers will measure pain scores and how much extra morphine is needed. The goal is to impro…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests whether injecting Botox or hyaluronic acid into the knee joint can reduce pain in people with knee osteoarthritis. Fifty adults aged 50 and older with moderate to severe knee arthritis will receive three weekly injections of one of the two treatments. The main go…

This study compares two exercise programs for people with knee osteoarthritis: supervised cycling on a stationary bike and a land-based therapeutic exercise program with strengthening and balance training. The goal is to see which approach better reduces pain sensitivity during a…

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This study tests whether an enhanced recovery after surgery (ERAS) protocol helps people recover faster after total knee replacement. About 120 patients aged 50-70 will either get standard care or the ERAS plan, which includes pre-surgery exercise, shorter fasting, and early walk…

This study tests an experimental drug called Allocetra, given as a shot into the knee joint, for people aged 64+ with moderate-to-severe knee osteoarthritis. The goal is to see if it reduces pain and improves function better than a placebo. About 270 participants will be followed…

This trial tests whether a short, temporary nerve stimulation can reduce pain in people with moderate to severe knee osteoarthritis. About 100 adults aged 30 to 70 who have not found relief from oral pain medications or physical therapy will receive a brief electrical pulse to sp…

This study compares two types of balance and strength exercises added to standard physical therapy for knee osteoarthritis. Sixty adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to one of two exercise programs. The goal is to see which approach be…

This study tests a powered boot-like device (exoskeleton) to see if it can help people with knee osteoarthritis walk more easily. Nine adults with knee pain who have trouble walking will try the device in a lab. The goal is to see if the device is comfortable and can reduce strai…

This study tests two ways to guide a treatment called cooled radiofrequency ablation for knee osteoarthritis pain. The treatment uses heat to calm nerves around the knee. Researchers want to see if using ultrasound is better than the standard X-ray method for targeting the right …

This trial compares two injection treatments for knee osteoarthritis: a combination of platelet-rich plasma (PRP) and hyaluronic acid versus hyaluronic acid alone. Researchers want to see if the combined approach provides better pain relief and function after one year. The study …

This study compares a combination of ibuprofen and acetaminophen to the opioid oxycodone for managing pain after thumb surgery (trapeziectomy) for osteoarthritis. About 121 adults will be randomly assigned to one of the two pain regimens and tracked for 30 days. The goal is to se…

This study looks at whether a special exercise method called blood flow restriction (BFR) can help reduce pain and improve muscle function in people with severe knee osteoarthritis who are waiting for knee replacement surgery. Participants will try six different exercise setups t…

This study tests whether doing leg exercises with a blood pressure cuff on the thigh can temporarily reduce pain in people with severe knee osteoarthritis who are waiting for knee replacement surgery. Forty-five participants will do two different exercise sessions (with either fi…

This study is tracking 1,200 adults with knee osteoarthritis who have not found relief from standard treatments. They will undergo a procedure called genicular artery embolization, which blocks certain blood vessels to reduce inflammation and pain. Researchers will follow partici…

This study tests whether giving patients a personalized prediction tool and extra support for mental health and physical function can improve satisfaction one year after knee replacement surgery. About 300 adults at higher risk of dissatisfaction will be randomly assigned to eith…

This study tests whether low-dose radiotherapy can reduce pain in people with knee osteoarthritis. 128 participants will receive either real radiation or a sham treatment three times a week for two weeks. Researchers will track pain scores and painkiller use for six months to see…

This study is testing whether cannabidiol (CBD) tablets can reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare pain levels between those taking CBD and those not taking it, alongside standard physical therapy. The study aims to enr…

This study looks at whether adding a technique called blood flow restriction (BFR) exercise to standard physical therapy can help people recover more quickly after total knee replacement. BFR uses a cuff to lightly restrict blood flow during low-weight exercises, which may help b…

This study tests a new pain self-management program designed specifically for Black adults aged 50 to 92 who have long-term muscle or joint pain (like arthritis or back pain). The program aims to reduce pain during movement and improve daily life. Researchers will compare pain le…

This study tests whether a compressive cryotherapy device (Game Ready®) can reduce the need for opioid painkillers after total knee replacement surgery. About 74 adults aged 60-80 will be randomly assigned to use either the device or traditional ice packs four times daily for a w…

This study looks at whether formal hand therapy is needed after surgery for thumb arthritis. About 180 adults having thumb joint surgery will be randomly assigned to either get standard in-clinic therapy or not. The goal is to see if skipping therapy affects thumb movement and fu…

This study tests whether a new nerve block (quadri-block) helps people recover better after total knee replacement compared to the usual method (adductor canal block plus surgical infiltration). One hundred adults with knee arthritis scheduled for knee replacement will be randoml…

This study tests whether a special cooling cuff works better than traditional ice packs for reducing swelling and pain after total knee replacement. About 102 adults having their first knee replacement will be split into two groups: one gets the cuff, the other gets ice packs. Th…

This study tests whether special shoe insoles can reduce pain in people with knee osteoarthritis who also have foot pain. About 31 participants will wear either lateral wedge insoles or insoles with added arch support for at least 5 hours a day over 3 months. Researchers will mea…

This study tests whether a pharmacist-led program can help patients reduce their opioid use by about half in the weeks before knee or hip replacement surgery. 45 adults on stable, moderate-dose opioids will work with a pharmacist to create a taper plan and get weekly check-ins. T…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study compares three versions of a nerve block (PENG block) for pain after hip surgery in adults aged 65 and older. All patients receive the same base anesthetic, but some get added medications (dexamethasone and dexmedetomidine) either through an IV or near the nerves. The …

This study compares three versions of a nerve block (PENG block) for pain relief in 120 adults aged 65 and older having hip surgery. One group gets the standard block, while two others get an added medication (dexamethasone or dexmedetomidine) to see if pain relief lasts longer. …

This study tests whether adding a mild electrical current (interferential current) to a standard exercise program can further reduce pain and improve function in people with knee osteoarthritis. 138 adults aged 40-75 with knee pain will be split into three groups: exercise only, …

This study tests whether an app called Genus, which provides videos, exercises, and quizzes, can help people with knee osteoarthritis learn more about their condition and feel more confident in treatment decisions. About 204 adults over 50 who are waiting for a specialist appoint…

This study compares two types of numbing injections for shoulder surgery. The standard method can sometimes weaken the diaphragm, the main breathing muscle. The new approach uses two different injection sites to avoid that side effect. Researchers will enroll 70 older adults havi…

This study tests whether sleeping near a special device that claims to emit 'biophotons' can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use either the active device or a placebo (inactive) device for 12 weeks. Researchers will measur…

This study compares two approaches to recovery after total knee replacement: a fast track plan designed to speed up recovery versus standard care. Researchers will measure how well patients can move and care for themselves after surgery, as well as how long they stay in the hospi…

This study looks at whether adding a special education program about chronic pain to standard exercise therapy can improve daily function and reduce pain in people with knee osteoarthritis. About 92 adults with knee OA will be randomly assigned to either exercise alone or exercis…

This study tests whether combining two nerve blocks (iPACK and adductor canal block) with a numbing drug called ropivacaine can reduce pain and inflammation after total hip replacement. Sixty older adults (65-100 years) having hip surgery will be randomly assigned to receive eith…

This study tests whether adding a nerve block (PENG block) to standard spinal anesthesia can reduce confusion after hip replacement in people aged 75 and older. About 180 participants will be randomly assigned to receive either the nerve block or a placebo injection. The main goa…

This study tests whether a gel containing pregabalin, applied through the skin using ultrasound (phonophoresis), combined with calf muscle stretching, can reduce nerve pain and improve walking in people with grade III knee osteoarthritis. The trial includes 35 adults aged 40-70 w…

This study looks at whether people who have knee replacement surgery can use remote monitoring and video calls instead of scheduled in-person follow-ups. About 140 patients will be split into two groups: one with standard hospital visits at 2 and 12 months, and another that answe…

This study follows 270 adults having knee replacement surgery to see if the steroid dexamethasone (given as a pill or through a vein) helps with early recovery. Researchers will measure pain, mobility, nausea, and need for extra painkillers. The study does not assign treatments—p…

This study tests whether an AI-assisted web app that personalizes home exercises can reduce pain and improve knee function in people with knee osteoarthritis, compared to a standard paper exercise program. About 84 adults with knee pain will be randomly assigned to either the AI …

This study tests two different ways to numb the back of the knee after total knee replacement surgery. Both methods are combined with a standard front-of-thigh block. The goal is to see which approach leads to better overall recovery, less pain, and less need for strong painkille…

This study tests whether wearing a thumb cast for 2 weeks after surgery is as good as wearing it for 6 weeks for people with thumb arthritis. About 90 adults aged 40 and older will be randomly assigned to one of the two recovery plans. Researchers will track pain, hand function, …

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether taking nefopam, a non-opioid painkiller, by mouth before and after knee replacement surgery can reduce pain and the need for morphine. About 50 adults having knee replacement will be randomly assigned to receive either nefopam or a placebo. The goal is to…

This study compares high intensity laser therapy to exercise for people with thumb osteoarthritis. The goal is to see which treatment better reduces pain and improves hand function. About 42 adults with thumb arthritis will be assigned to one of the two treatments and followed fo…

This study tests whether progressive resistance exercises or aerobic exercises better improve knee cartilage and physical function in people aged 35-55 with degenerative meniscus tears. 45 participants will be split into three groups: resistance training, aerobic training, or sta…

This study compares two methods of pain control during knee replacement surgery. One uses numbing medicine injected into the knee area only. The other adds nerve blocks to that injection. The goal is to see which approach provides better pain relief and reduces the need for stron…

This study tests whether adding special balance platform exercises to standard physical therapy can improve pain, balance, and daily function in people with knee osteoarthritis. About 36 adults aged 45-65 with moderate knee arthritis will be randomly assigned to either standard t…

This study tests whether an injected drug called pentosan polysulfate sodium can reduce knee pain and improve function in people with knee osteoarthritis. About 466 adults with moderate to severe knee arthritis who haven't found relief from other treatments will receive either th…

This study tests if a procedure called arterial embolization using Lipiodol is safe for people with painful hand osteoarthritis that hasn't improved with standard treatments. Fifteen participants will receive the procedure and be followed for 6 months to track side effects, pain …

This study tests three home-based programs for people with long-term muscle or joint pain (like back pain or arthritis) who also sleep poorly. Participants will be randomly assigned to 12 months of exercise, cognitive behavioural therapy for insomnia (CBT-I), or both. The goal is…

This study tests whether a 10-week telehealth program that combines gentle exercise with mindfulness can help people with knee osteoarthritis feel less pain and move better. Researchers will compare the mindful exercise group to an exercise-only group. All sessions happen remotel…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study tests whether Multiprofen-CC cream, applied three times daily, reduces pain in adults with hand osteoarthritis. Forty-two participants will use both the active cream and a placebo for two weeks each, in random order. Researchers will measure pain, hand function, and si…

This pilot study compares custom-made, 3D-printed knee implants (YourKnee) to standard off-the-shelf implants in 20 people with knee osteoarthritis. The custom implants are designed based on each patient's unique knee shape and are placed using patient-specific cutting guides. Th…

This study looks at which extra features added to an online exercise program help people who have had a knee replacement become more active. About 336 adults who had knee surgery at least a year ago and currently do little exercise will take part. Researchers will track changes i…

This study compares two types of nerve blocks to control pain after total knee replacement. 78 adults will receive one of two combinations of ultrasound-guided injections near the knee. The goal is to see which approach reduces pain and the need for opioid painkillers in the firs…

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and moderate to severe arthritis will receive one of the two injections. The goal is to see if the hydrogel reduces pain, stiffn…

This study compares two ways to manage pain after total knee replacement: a single-shot nerve block versus a continuous nerve block using a small catheter. About 94 adults having knee surgery will be randomly assigned to one method. The goal is to see which approach reduces opioi…

This study tests whether filling the bone gap with a synthetic putty (AttraX Putty) during knee realignment surgery can reduce pain in the first week after surgery. About 40 adults with knee osteoarthritis will be randomly assigned to get the putty or standard surgery without a g…

This study looks at whether a structured physical therapy program can improve how people walk and distribute weight on their feet after total knee replacement surgery. Researchers will measure walking speed, step length, and foot pressure in 30 female participants before and afte…

This study tests whether 99Tc-MDP (Yunke), a drug already used for rheumatoid arthritis, can reduce pain and stiffness in people with knee osteoarthritis. It compares the drug to celecoxib, a common painkiller. The trial will enroll 40 participants and measure changes in pain, jo…

This study is testing whether giving extra doses of tranexamic acid (TXA) after hip or knee replacement surgery can reduce bleeding, pain, and help people move around sooner. TXA is a drug already used during surgery to prevent blood loss. The trial will compare the standard sing…

This study tests whether high-intensity laser therapy (HILT) plus exercise works better than standard physical therapy plus exercise for knee osteoarthritis. One hundred adults aged 40 to 75 with knee arthritis will be split into two groups to compare pain relief, joint function,…

This study tests whether a painless, needle-free treatment called transcutaneous pulsed radiofrequency acupuncture can reduce pain and stiffness in people with knee osteoarthritis. About 90 adults aged 45 to 85 with long-term knee pain will receive the treatment along with standa…

This study tests whether starting physical therapy early after hip replacement, combined with electrical muscle stimulation and remote video coaching, helps people walk better and regain strength faster. About 52 adults aged 50-75 will be split into two groups: one gets the extra…

This study tests whether injecting dextrose (a sugar solution) into specific spots seen on MRI works better than injecting it into the knee joint for osteoarthritis. Sixty adults aged 45-80 with moderate knee OA will receive either MRI-guided extra-articular or ultrasound-guided …

This study is testing whether using a special sensor device during knee replacement surgery leads to better results for patients. The device helps the surgeon make precise bone cuts. Researchers will follow 40 people for up to 2 years after surgery, measuring pain, function, and …

This study compares two alignment techniques—kinematic and functional—used during robotic-assisted total knee replacement. 240 people with knee osteoarthritis will be randomly assigned to receive one of two types of implant inserts. Researchers will track how well patients forget…

This study tests a new nerve block called BiFeS against the standard iPACK block for pain after knee replacement surgery. 88 adults having a knee replacement will be randomly assigned to receive one of the two blocks. The goal is to see which provides better pain relief and helps…

This study tests whether a pain management plan that limits opioids can help adults who need hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior total hip replacement will be randomly assigned to either the opioid-sparing …

This study will follow 86 adults with knee osteoarthritis to see if injections of sugar-water (dextrose) or local anesthetic around the knee nerves provide better pain relief and function. Participants will be assessed for six months after their routine injection. The goal is to …

This study tests whether Epidiolex (a CBD medicine) can help control pain after shoulder surgery when added to standard painkillers. About 80 adults having rotator cuff repair will take either CBD or a placebo for two weeks after surgery. They will track their pain and medication…

This study compares two pain-relief methods after total knee replacement: a single injection into the adductor canal versus a continuous nerve block in the thigh. The goal is to see which approach helps patients walk farther and recover faster without increasing fall risk. About …

This study tests whether cannabidiol (CBD) can lower the need for opioid painkillers after knee replacement surgery. 380 adults with knee osteoarthritis will take CBD or a placebo before and after surgery. Researchers will measure total opioid use and pain over 28 days to see if …

This study tests three different numbing medicine combinations for pain after total knee replacement. 90 adults having knee surgery will get one of three options: a long-acting numbing drug, or a standard numbing drug plus one of two additives. The goal is to see which approach r…

This study compares two approaches for older adults with knee osteoarthritis and insomnia: personalized exercise coaching alone versus exercise plus a digital insomnia treatment. Researchers want to see if adding sleep therapy leads to greater pain relief. The trial involves 288 …

This study looks at whether a single dose of the anti-inflammatory drug dexamethasone, given during hip replacement surgery, can help patients feel better and recover faster. About 224 adults aged 60 and older having a hip replacement will receive either a low or moderate dose of…

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

This study tests a procedure called transarterial microembolization (TAME) for people with knee osteoarthritis and long-lasting pain that hasn't improved with standard treatments. Doctors will inject tiny beads into blood vessels around the knee to block abnormal blood flow, aimi…

This pilot study tests whether wearing a knee extension brace for the first 72 hours after total knee replacement can reduce pain and improve recovery. 106 participants will be randomly assigned to either the brace or standard care with early movement. The main goal is to see if …

This study tests a new knee injection called ALLOHEAL for people with knee osteoarthritis. The injection contains natural substances to reduce friction in the joint and ease pain. About 286 adults aged 40 to 79 with knee pain will receive either ALLOHEAL or a similar approved tre…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement surgery can reduce pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or sur…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests whether a hands-on technique called gastrocnemius myofascial release (a type of calf muscle massage) can reduce pain and improve physical function in women aged 45-55 with knee osteoarthritis. Thirty participants will receive either the real treatment or a sham v…

This study tests whether injecting Botox into the thumb joint can reduce pain and improve hand function in people with base-of-thumb osteoarthritis. 120 adults with moderate to severe thumb pain will receive either two Botox injections, one Botox and one placebo, or two placebo i…

This study looks at how a person's background and their clinic visit affect knee osteoarthritis pain relief using topical diclofenac gel. 220 adults aged 50+ with knee OA will apply the gel for 8 weeks and answer questions about their pain. Researchers will also analyze blood sam…

This study compares two types of knee replacement implants designed to work with a newer, more natural surgical technique called kinematic alignment. The goal is to see which implant helps patients feel more like their knee is their own, with less stiffness and pain. About 120 pe…

This early-stage study tests a single injection of AVD275, a new form of the pain reliever celecoxib, in 15 adults with knee osteoarthritis. The goal is to check safety and how the drug spreads in the body. Participants will be monitored for 24 weeks after the shot.

This study tests whether taking creatine supplements for 12 weeks helps adults aged 65 and older regain muscle mass, strength, and physical function after total knee replacement surgery. Participants will take creatine or a placebo daily alongside standard rehabilitation. The goa…

This study tests if focused shockwave therapy can safely reduce knee pain and improve function in people with osteoarthritis who have bone marrow lesions. Fifteen adults with persistent knee pain will receive four weekly shockwave sessions or standard care (pain relievers and res…

This study tests whether remimazolam, a newer anesthesia drug, causes less confusion (delirium) after surgery than the standard drug propofol in elderly patients having hip or knee replacement. Researchers will monitor 82 participants for three days after surgery to check for del…

This study compares two types of computer-assisted knee replacement surgery: one using a navigation system (OrthoPilot) and one using a robotic arm (MAKO). The goal is to see if they provide similar improvements in knee function and pain relief one year after surgery. About 140 a…

This study looks at whether keeping or removing the posterior cruciate ligament during robotic knee replacement helps patients feel more natural after surgery. About 300 adults having their first robotic knee replacement will be randomly assigned to one of the two methods. The ma…

This study tests whether the BETY exercise program, which combines physical exercises with pain management and emotional support, can help people with knee osteoarthritis who recently received injections. Sixty adults with knee osteoarthritis will be enrolled. The goal is to see …

This study compares two methods of knee replacement surgery: traditional mechanical alignment (MA) and newer kinematic alignment (KA) that mimics the knee's natural position. About 95 adults with knee arthritis will be randomly assigned to one method and followed for 6 weeks. The…

This study compares two ways to recover after total knee replacement: standard outpatient physical therapy versus using a smart knee brace (FM2) at home. Eighty adults who need knee replacement will be randomly assigned to one of the two groups. Researchers will measure knee moti…

This study tests two ways to manage pain after hip replacement surgery. One group gets a nerve block plus a second nerve block; the other gets a nerve block plus wound numbing. The goal is to see which method reduces pain and the need for opioid painkillers. About 102 adults havi…

This study tests an investigational drug called ALT001 for people with knee osteoarthritis. The goal is to see if it can reduce pain, improve movement, and boost quality of life. About 30 adults aged 50 to 75 will receive injections into the knee every two weeks for 12 weeks. The…

This early-stage trial tests a new drug called HRS-2129 in 200 people with moderate to severe knee osteoarthritis pain. Participants will receive either HRS-2129, a placebo, or an active comparator (celecoxib) to see if it reduces pain and improves joint function. The study is do…

This study looks at whether adding core stabilization exercises to standard knee exercises can improve symptoms and function in women aged 40-65 with knee osteoarthritis. Forty participants will receive either knee exercises alone or knee exercises plus core exercises for six wee…

This study compares two treatments for chronic knee osteoarthritis: shock wave therapy and structured exercise. Forty adults aged 40 and older with persistent knee pain will be randomly assigned to one of the two groups. The goal is to see which approach better reduces pain and i…

This study compares two treatments for chronic hip pain caused by osteoarthritis: a nerve block alone versus a nerve block plus pulsed radiofrequency. About 84 adults with hip pain lasting at least 3 months will be enrolled. The goal is to see if adding radiofrequency provides be…

This phase 3 trial is testing whether adding metformin, a diabetes drug, to standard pain relief (celecoxib) can reduce pain and improve knee function in people with knee osteoarthritis. The study will enroll 70 adults aged 30-60 with moderate knee arthritis. Researchers will mea…

This study tests whether a low dose of steroid injected into the knee works as well as the standard dose for reducing pain and improving function in obese people with knee arthritis. Forty participants will receive either a low or standard dose and report their pain levels and da…

This study tests whether adding dexmedetomidine to a standard nerve block (PENG block) can provide longer pain relief after hip surgery in adults aged 65 and older. Thirty participants will be randomly assigned to receive either the nerve block alone or with dexmedetomidine. The …

Some people hear clicking or popping after knee replacement surgery, which can be bothersome. This study compares two different knee replacement designs to see if one causes less noise. Researchers will ask 170 patients about the sounds they hear and how much it bothers them over…

This study compares a special cold compression device (cryopressotherapy) to standard ice packs for people recovering from total knee replacement. Researchers will measure pain, mobility, swelling, and patient-reported outcomes 14 days after surgery. The goal is to see if the dev…

This study compares three types of nerve blocks (PENG, S-FICB, and L-ESPB) to see which provides the best pain relief after hip replacement while preserving leg strength for early walking. Researchers will enroll 93 adults aged 65 and older undergoing hip surgery. The goal is to …

This study tests whether giving a steroid (dexamethasone) during shoulder replacement surgery can improve recovery. Researchers will measure pain, nausea, shoulder movement, and how long patients stay in the hospital. The study involves 74 adults with shoulder arthritis who are h…

This study tests whether Reiki, a gentle energy-based touch therapy, can reduce pain and help patients move better after total knee replacement surgery. 90 adults having planned knee surgery will be randomly assigned to receive either Reiki or standard care. Researchers will meas…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This study tests whether adding cognitive behavioral therapy (CBT) to standard physical therapy helps people who have had a hip replacement overcome fear of movement and improve their recovery. One hundred participants will be split into two groups: one gets standard rehab exerci…

This study tests whether an NSAID injection (ketorolac) works better than a steroid injection (triamcinolone) for easing pain from moderate to advanced thumb arthritis. About 240 adults over 40 with persistent thumb pain will receive one type of injection and report their pain le…

This study compares a mix of telerehabilitation (10 remote sessions) plus in-person physiotherapy against standard in-person rehab (16 sessions) for people who have had a total hip replacement. Researchers will measure pain, function, and patient satisfaction in 104 adults aged 5…

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study tests a new exercise program using a flywheel device to improve stair-climbing in people with knee osteoarthritis. The training focuses on the muscle-lengthening phase of movement, which may build better muscle and coordination. Researchers will measure changes in move…

This study compares two common shoulder injections—corticosteroids and platelet-rich plasma (PRP)—to see which provides better pain relief for people with advanced shoulder arthritis. About 200 adults with bone-on-bone arthritis will receive one of the two injections and report t…

This study tests whether adding a special brain-training technique called graded motor imagery to standard exercise can help people with foot or ankle osteoarthritis feel less pain and move better. Twenty-four adults with confirmed osteoarthritis will be randomly assigned to eith…

This study tests whether a structured preparation program before hip or knee replacement surgery can help people recover faster. The program includes personalized exercise, nutritional advice, stress and pain support, and medication review. Researchers will compare recovery in 18…

This study tests whether a type of exercise called diagonal proprioceptive neuromuscular facilitation (PNF) can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare PNF exercises to standard strength training in 150 adults aged 40-60. Both…

This study tests a portable, seated leg dexterity trainer designed to improve knee control and reduce pain in people with knee osteoarthritis. About 82 adults aged 40-85 with knee OA will use either the new device or a wobble board at home for 8 weeks. The goal is to see if the d…

This study tests whether proactive outreach—sending materials and making two phone calls—can encourage older adults with osteoarthritis to use their free SilverSneakers exercise benefit. About 1,454 seniors across the U.S. will be followed for two years to see if they become more…

This study tests whether a combination of platelet-rich plasma (PRP) and hyaluronic acid injections works better than either treatment alone for knee osteoarthritis. About 288 adults aged 40 to 75 with knee pain will receive one of three treatments. The goal is to see if the comb…

This study tests whether doing supervised exercise and learning about recovery before total knee replacement helps patients feel better and function better one year after surgery. About 110 adults with knee osteoarthritis awaiting surgery will be randomly assigned to either the p…

This study compares two ways to manage pain after total knee replacement in 80 adults aged 65 and older. Both methods use a nerve block in the thigh (adductor canal block) plus either a block near the sacrum or one behind the knee. The goal is to see which combination provides lo…

This study is testing whether low-impact group exercise classes can help reduce pain in people with knee, hip, or ankle osteoarthritis. Participants attend one-hour group sessions three times a week for six months, led by a physical therapist or trainer. The study also includes s…

This study tests a minimally invasive treatment for chronic knee pain from osteoarthritis or after knee replacement. Doctors guide a thin tube to knee arteries and inject a temporary agent to reduce blood flow to inflamed tissue. The goal is to see if this procedure safely reduce…

This study compares two common additives (dexamethasone and dexmedetomidine) mixed with a numbing drug to see which one reduces pain and the need for strong painkillers after total knee replacement. About 96 people aged 65 and older will take part. The goal is to find a safer, mo…

This study tests two different methods of a nerve block (iPACK) to manage pain after total knee replacement. The goal is to find which approach provides better pain relief and reduces the need for strong painkillers. 120 adults having knee replacement will be randomly assigned to…

This study tests whether a single injection of collagen into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare the collagen injection to a placebo (saline) injection in 204 adults. The main goal is to see if collagen …

This study looks at whether a 6-month thermal spa treatment program can meaningfully reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare results from 76 participants aged 50-80 who receive the spa therapy against an external group r…

This study tests whether a supplement made from boswellia, turmeric, and grape extracts can reduce pain and stiffness in people with knee or hip osteoarthritis. Thirty adults will take the supplement or a placebo for four weeks each, then switch. Researchers will measure changes …

This study looks at whether text message reminders and physical activity coaching can help more people with osteoarthritis start and stick with a walking program. Researchers will enroll 346 adults aged 45 and older who have knee, hip, or spine arthritis. The goal is to reduce pa…

This study compares a special cold-and-compression device to regular ice packs for managing pain after total knee replacement. About 138 adults having knee surgery will be randomly assigned to one of the two treatments. The main goal is to see if the device reduces pain more than…

This study tests whether using virtual reality for relaxation exercises can reduce pain and improve sleep better than traditional relaxation methods in people recovering from hip or knee replacement surgery. About 82 adults who speak Turkish and have no mental or sleep disorders …

This study tests whether a simple saline (salt water) injection works as well as a steroid injection for thumb arthritis pain. Forty adults with thumb osteoarthritis will receive one injection, but neither they nor their doctor will know which one. The goal is to see if saline ca…

This study tests a new injection called CartiPRO to see if it can safely reduce knee pain in people with osteoarthritis. About 194 adults will receive either CartiPRO or another approved injection, and then get a second shot 24 weeks later. Researchers will measure pain and knee …

This study tests whether teaching patients about nutrition and following a specific fasting plan before knee replacement surgery can help reduce thirst, nausea, and vomiting afterward. About 72 adults having knee replacement will be split into two groups: one gets the special edu…

This study compares two methods of using radiofrequency to treat chronic neck pain caused by arthritis in the small joints of the neck. About 72 adults with moderate to severe neck pain for at least 3 months will be randomly assigned to one of two needle techniques. The goal is t…

This study compares two ways of giving platelet-rich plasma (PRP) injections for chronic knee osteoarthritis: one into the joint only, and another that also targets tissues around the knee. Researchers want to see if the combined approach better reduces pain, improves daily funct…

This study tests whether injecting a common steroid into muscle trigger points can relieve long-term shoulder pain and certain headaches as well as injecting into the joint. About 1,000 adults aged 45 and older with shoulder arthritis will receive either a trigger point or joint …

This study tests whether injecting a steroid and numbing medicine into muscle trigger points can relieve knee osteoarthritis pain as well as injecting into the knee joint itself. About 1,000 adults with knee arthritis and at least one tender muscle spot will receive either a trig…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This study compares two types of injections for hip osteoarthritis pain: one into the joint and one into nearby muscle trigger points. Over 1,000 adults with hip pain will be randomly assigned to one of the two groups and followed for two years. The goal is to see if the simpler …

This study looks at using different amounts of steroids injected into the knee during total knee replacement surgery to control pain. Researchers want to find the safest and most effective dose to help patients recover faster and feel better. The trial involves 120 adults having …

This study tests whether frozen platelet-rich plasma (PRP) injections can reduce pain and improve knee function in people with knee osteoarthritis. About 60 adults aged 40-85 with mild to moderate knee arthritis will receive either frozen PRP or fresh PRP injections. The goal is …

This study tests whether hyaluronic acid injections into the knee can reduce pain and improve function in people with knee osteoarthritis. Researchers will also measure changes in inflammation-related substances in blood and joint fluid. 50 adults aged 45-75 with moderate knee os…

This study compares two treatments for shoulder pain caused by arthritis or rotator cuff problems: a steroid injection into the joint versus a nerve block. Forty adults with shoulder arthritis will be randomly assigned to one of the two treatments. Researchers will track pain lev…

This study tests whether teaching older adults to press specific points on their body (self-administered acupressure) can reduce knee osteoarthritis pain. About 368 Chinese adults aged 60+ with knee pain will learn the technique in two sessions and practice at home. Researchers w…

This study tests whether a faster rehabilitation program helps people recover better after total knee replacement surgery. Researchers will compare the accelerated program to standard rehab in 32 adults aged 50-80. The goal is to see if the faster approach improves knee function …

This study tests whether injecting a mix of hyaluronic acid and fibrinogen into the knee can reduce pain and improve function in people with knee osteoarthritis. About 31 adults aged 45 to 75 will receive the injection as part of routine care. Researchers will track changes in pa…

This study compares two surgical treatments for rhizarthrosis, a type of arthritis at the base of the thumb. One group gets a new prosthesis (HORUS implant), the other gets the standard trapezectomy. Researchers will measure hand function and pain in 50 patients over the short te…

This study tests whether supplements made from agar-agar (a seaweed extract) and undenatured type II collagen can reduce knee pain in people with osteoarthritis. Eighty adults aged 40 to 70 with mild to moderate knee pain will take capsules daily for several weeks. The goal is to…

This study tests whether combining functional electrical stimulation (FES) with exercise can improve quadriceps muscle strength and reduce pain in people with knee osteoarthritis. Researchers will measure muscle strength, pain levels, and quality of life in 52 participants aged 5…

This study tests whether injecting a person's own bone marrow cells or a mix of fat cells and platelet-rich plasma into the knee can reduce pain from osteoarthritis. About 148 adults with moderate knee arthritis will receive either the real treatment or a placebo (salt water) inj…

This study tests whether an 8-week yoga program can improve physical function and reduce pain in people with knee osteoarthritis. Researchers will compare yoga to standard therapeutic exercises in 90 adults aged 45 and older. The goal is to see if yoga offers extra benefits for m…

This study tests a gel called Synolis VA 80/160 for people with painful hip osteoarthritis. The goal is to see if it reduces pain and improves hip function over 6 months. About 70 adults with moderate hip arthritis who haven't gotten enough relief from standard painkillers will t…

This study looks at whether giving the painkiller nalbuphine at different times during knee replacement surgery can better control pain and keep the heart stable in patients aged 65 and older. About 162 participants will receive nalbuphine either during anesthesia or after cement…

This study tests whether taking GlyNAC (a mix of two natural amino acids) before and after knee replacement surgery can reduce chronic pain. 148 adults with knee osteoarthritis will take either GlyNAC or a placebo for 4 weeks before surgery and 6 weeks after. Researchers will tra…

This study tests whether adding a fall prevention program to standard physical therapy can reduce falls and improve balance in older adults who have had a total knee replacement. About 90 women aged 60 and older will be followed for 24 weeks. The program includes guidance on avoi…

This study is testing whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve function in athletes who developed knee osteoarthritis after ACL reconstruction. Researchers will treat 70 participants with a device that delivers pressure waves to the knee. The go…

This study tests whether adding a sugar solution (dextrose) to numbing injections around the knee nerves provides better pain relief than numbing medicine alone for people with chronic knee osteoarthritis. Sixty adults with knee arthritis will receive a series of three injections…

This study compares two common knee injections—platelet-rich plasma (PRP) and hyaluronic acid (HA)—for treating osteoarthritis behind the kneecap. About 166 adults aged 30–65 will receive a single injection and be followed for 12 months to see which provides better pain relief an…

This study tests whether a special light (810 nm) can reduce knee pain and swelling in people with chronic knee pain and synovitis. About 80 adults aged 40-80 will receive either real light therapy or a sham treatment twice a week for five weeks. Researchers will measure pain, ul…

This study tests three different doses of a long-acting numbing medicine (liposomal bupivacaine) injected into a nerve block in the thigh to control pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to receive one of the dos…

This study tests whether turmeric, a common spice, can reduce pain and stiffness in people with thumb arthritis. Sixty adults will take either turmeric or a placebo three times a day for six weeks. Researchers will measure changes in pain and hand function to see if turmeric offe…

This study looks at whether taking ibuprofen (a common painkiller) along with dextrose prolotherapy injections affects pain and function in people with knee osteoarthritis. Researchers will give 68 adults either ibuprofen or a placebo for 7 days after each of three injections. Th…

This study compares a new procedure called genicular artery embolization (GAE) using Nexsphere-F microspheres against standard steroid injections for knee osteoarthritis. About 126 people with knee pain will be randomly assigned to one of the two treatments. The goal is to see if…

This study tests whether an ultrasound-guided lumbar erector spinae plane (ESP) block can improve pain control after total hip replacement. Sixty adults having hip surgery will be randomly assigned to receive either the nerve block plus standard pain medication or standard medica…

This study will follow 500 people with knee injuries or knee osteoarthritis who receive standard care at a hospital in China. Researchers will collect medical history, imaging, and function tests at the start and then again at 6, 12, and 24 months. The goal is to better understan…

This study looks at whether ultrasound measurements of thigh muscle and fat can predict how well patients with knee osteoarthritis respond to a genicular nerve block. Researchers will measure muscle thickness and fat under the skin before the procedure and check pain levels one m…

This study aims to understand why bones weaken with age, leading to conditions like osteoporosis and osteoarthritis. Researchers will collect bone waste and blood samples from 2,000 people undergoing orthopedic surgery, including those with and without bone disease. By analyzing …

This study looks at how the rotator cuff muscles are doing one and two years after total shoulder replacement surgery. Researchers will use EMG and CT scans to check for nerve damage or tears in the muscles. About 30 adults who had shoulder replacement for osteoarthritis will tak…

After knee replacement, a nerve block called the adductor canal block is often used to control pain while preserving leg strength. But it does not work equally well for everyone. This study will examine whether ultrasound measurements—such as tissue depth and nerve visibility—can…

This study looks at whether it's possible to run a larger trial of a community-based program called Good Boost+ for adults waiting for knee replacement surgery. The program includes weekly group water exercises and land-based exercises, plus peer support. Researchers will measure…

This study uses a special ultrasound technique called shear wave elastography to measure the stiffness of knee ligaments in healthy adults and in people with knee osteoarthritis. The goal is to establish normal stiffness values across different ethnic groups and to see how ligame…

This study examines whether two substances in the blood, Fetuin-A and COMP, are linked to the severity of knee osteoarthritis. Researchers will compare 120 people with knee osteoarthritis to 60 healthy volunteers, measuring their pain, mobility, and joint damage on X-rays. The go…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study will use advanced CT and MRI scans to see how knee realignment treatments (surgery or braces) affect bone structure and cartilage in 30 people with early knee osteoarthritis. Researchers want to understand why some treatments fail, so they can improve care for younger …

This study will compare women with knee osteoarthritis who also have lipedema (a fat tissue disorder) to those without lipedema. Researchers will use ultrasound to measure knee cartilage thickness and questionnaires to assess pain and daily function. The goal is to understand if …

This study investigates knee osteoarthritis and cartilage degeneration by combining MRI scans with gait analysis. Researchers aim to better understand how the disease affects both the structure and function of the knee joint. The study involves 25 participants with knee pain or c…

This pilot study aims to see if a new method can safely measure how tired patients get during a special type of exercise after total knee replacement. Twenty adults recovering from knee surgery will try cycling while blood flow to their legs is partially restricted. The results w…

This study explores whether a substance called thromboxane A2, which is involved in blood clotting and fat metabolism, also plays a role in osteoarthritis. Researchers will measure thromboxane levels in blood and joint fluid from 20 people with knee osteoarthritis and look for a …

This study looks at two types of fat tissue in people with knee osteoarthritis: one inside the knee joint (Hoffa's fat pad) and one inside the thigh muscle. Researchers want to see if these fat deposits are different in size, fat content, and scar tissue. The goal is to better un…

This study will follow 78 people aged 50 to 85 who need a total knee replacement to see how well a newer all-polyethylene (plastic) knee implant holds up over 5 years. Researchers want to know if this design, which may be cheaper and have fewer mechanical problems, works as well …

This study looks at joint tissue from people with early osteoarthritis to find different patterns of inflammation. Researchers will take small samples using a needle under local anesthetic, along with blood tests. The goal is to better understand how the disease starts and progre…

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study follows about 100 adults who received a Tipmed hip replacement during routine care. Researchers track complications and hip function over two years to see how well the device performs in real life. The goal is to gather practical evidence on safety and effectiveness, n…

This study collects information from 10,000 adults who have had hip or knee replacement surgery at Heidelberg University Hospital. Researchers will follow participants during routine check-ups to see how long the artificial joints last, how well they function, and what problems m…

This study follows 800 people with thumb arthritis to find out which treatments—surgical or non-surgical—work best for pain relief and hand function. Participants continue their usual care, and researchers track their progress over time. The goal is to learn what helps most, not …

This registry follows 5000 people who have received Dezawa MuseCells as part of their routine care for conditions like osteoarthritis, pain, and wound healing. Participants report their symptoms and any side effects through online surveys over five years. The goal is to understan…

This observational study collects tissue samples from children undergoing surgery for polydactyly or hip dislocation, as well as from biobanks, to see which cells are best at forming cartilage. Researchers will test these cells in the lab and in animal models. The goal is to lear…

This study looks at whether a person's expectations before starting physical therapy can predict how much they will benefit from it. Researchers will track 84 adults over 50 with knee osteoarthritis as they go through 15 sessions of standard physical therapy. The goal is to see i…

This study aims to develop a better way to locate painful inflammation in the knee joint for people with patellofemoral osteoarthritis. Researchers will use a special PET/MRI scan to see how inflammation changes when the knee is under pressure. About 50 adults, including both pat…

This study compares two ways of tracking recovery after knee replacement surgery: traditional paper questionnaires filled out at the clinic versus digital surveys sent to a patient's smartphone. Researchers will enroll 50 adults aged 18-78 who own a smartphone, tablet, or compute…

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

This study tests whether using a smartphone app (Google Forms) to fill out recovery questionnaires after hip replacement is as good as the traditional paper method. Researchers will compare how many patients complete the digital survey on time versus the paper one. The goal is to…

This study compares three types of hip replacement surgery—traditional total hip arthroplasty, a neck-preserving Minihip, and hip resurfacing—to see which one best restores the hip's natural biomechanics. Researchers will use CT scans and X-rays before and after surgery to measur…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study is creating a registry to track how well a procedure called genicular artery embolization (GAE) works for knee osteoarthritis pain over time. Up to 100 adults with mild to moderate knee arthritis that hasn't improved with standard treatments will be enrolled. The goal …

This study is creating a large collection of joint fluid and blood samples from 500 people with different types of arthritis. Researchers will use these samples to test new biomarkers that could help diagnose arthritis earlier and monitor how the disease changes over time or with…

This study compares two advanced technologies used in total knee replacement: computer-assisted navigation and robotic-arm assistance. Both aim to place the new knee joint more precisely. The trial will follow 140 patients for two years to see if one method helps them forget they…

This study is looking at how the shape and alignment of the kneecap joint relate to knee pain. Researchers will take 3D CT scans of the knee while people stand (weight-bearing) to see the joint in a natural position. They hope to find links between specific bone measurements and …

This study looks at whether a doctor's computer tool (MedSafer) and patient brochures (EMPOWER) can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic diseases who take five or more regular drugs. Researchers will follow 100 particip…

This study aims to find out if brain-based tests can predict who will get pain relief from common knee osteoarthritis treatments. About 180 adults with knee pain will be randomly assigned to take duloxetine, celecoxib, or a placebo for 20 weeks. Researchers will use brain MRIs, k…

This pilot study is testing whether increasing daily steps can improve knee cartilage health in people who have had ACL reconstruction. Fifty-six participants will wear a Fitbit and receive daily step goals via text for 16 weeks. Researchers will use MRI scans to measure changes …

This study is creating a registry of up to 10,000 people who are having total joint replacement surgery for osteoarthritis. Researchers will collect surveys before and after surgery to measure pain, function, and satisfaction. The goal is to learn which treatments work best and i…

This study is a long-term check on the safety and performance of the MADISON total knee replacement system. It will follow 1,000 adults in France who need knee replacement surgery for up to 15 years. The goal is to track how often the implant needs to be revised or causes problem…

This study uses small wearable sensors to measure how people with severe knee osteoarthritis move before and after total knee replacement surgery. Researchers will track 20 patients over age 60 to see if these sensors can detect changes in knee motion and pain. The goal is to fin…

This study follows 5,000 adults receiving SERF hip prostheses for up to 15 years to see how long the implants last and how well patients function afterward. Researchers will track survival rates of the devices and measure improvements in mobility and pain using standard scores. T…

This study looks at two different methods of placing a total knee prosthesis: mechanical alignment (standard, fixed angles) and kinematic alignment (customized to each patient's anatomy). Researchers want to see which technique leads to better knee movement and function during ac…

This study looks at how the bones in the shoulder joint touch each other in people with shoulder arthritis, both before and after they get a shoulder replacement. The goal is to find out why some shoulder implants loosen over time. Researchers will use special X-rays and CT scans…

This study follows 450 adults with gout, CPPD (a crystal-related joint disease), or osteoarthritis to see how crystal deposits in joints and blood vessels change over time. Participants receive routine care and undergo ultrasound and lab tests every six months for up to 10 years.…

This study compares a standard and a new system for collecting bone marrow from the hip. Six adults aged 18–50 having minimally invasive hip repair will provide samples from both hips. The goal is to see which method collects more stem cells, cytokines, and growth factors. No new…

This study looks at how bone density changes around two types of knee replacement implants over two years. About 50 people getting a cemented total knee replacement will join. Researchers will use special X-rays to measure bone loss and track how well the knee works. The goal is …

This study checks if a standardized ultrasound scoring system for knee osteoarthritis works well in Turkish patients. Researchers will compare ultrasound findings with pain and function questionnaires in 100 adults aged 45 and older. The goal is to see if this method is reliable …

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study follows 2500 people who have had hip replacement surgery with Corin implants. Researchers will check how long the implants last and how well they work over 10, 15, and 20 years. The goal is to gather safety and performance data, not to test a new treatment.

This study tests whether platelet-rich plasma (PRP) injections into the knee can change certain proteins in the blood of people with knee osteoarthritis. About 60 participants aged 18-70 will receive either PRP or a saltwater placebo, and researchers will compare protein levels t…

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing only the lower body) for people having hip or knee replacement surgery. Researchers will track recovery time, pain, nausea, infections, and other complications in about 2,400 participants.…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is feasible for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and some will be interviewed. The goal is to see if th…

This study looks at whether brain scans can predict if someone will be satisfied after knee replacement surgery. Up to 1 in 5 patients still have pain or trouble moving after surgery, and doctors can't currently predict who. Researchers will scan the brains of 50 adults before an…

This study aims to improve total knee replacement surgery for people with severe knee arthritis and a bow-legged (varus) deformity. Researchers will use advanced CT scans to compare the angle of the affected leg with the healthy leg, helping surgeons decide how much to correct th…

This study aims to see if artificial intelligence can use a patient's genetics, biomechanics, and psychology to predict how well they will recover after total knee replacement. Researchers will enroll 197 adults with severe knee osteoarthritis and follow them for a year. The goal…

This study looks at how accurately people with thumb base osteoarthritis can sense their thumb's position and movement. Researchers will compare these measurements between 100 participants with arthritis and healthy volunteers. No treatment is given; the goal is simply to underst…

This study compares two ways of closing the wound after hip or knee replacement surgery: barbed sutures (a newer type) versus conventional sutures. About 90 adults having hip or knee replacement will be randomly assigned to one method. Researchers will track wound healing, compli…

This study looks at whether muscle power and control can predict falls better than muscle strength in people aged 65-80 with knee osteoarthritis. Fifty participants will undergo muscle tests, walking analysis, and MRI scans. The goal is to develop a fall-risk assessment tool for …

This study follows 50 people who had knee realignment surgery (high tibial osteotomy) for early knee arthritis. Researchers want to see how the surgery affects the kneecap joint and arthritis progression over the long term. Participants are under 65 and had the surgery at least 5…

This study follows 600 people with hip or knee osteoarthritis for one year to understand how their symptoms and daily function change over time. Participants fill out online questionnaires every two weeks and try different self-care programs through a web app called ArtroseCoach.…

This study looks at how bone density in the thigh bone changes after knee replacement surgery. Researchers will compare two ways of fixing the new joint: with cement or without. They will also compare surgery done by hand versus with a robot. 100 people aged 55 and older will tak…

This study will follow 300 people with knee osteoarthritis or chronic inflammatory arthritis for up to 10 years. Researchers will collect blood, joint fluid, and platelet-rich plasma samples to look for biomarkers linked to pain, joint damage, and the need for knee replacement. T…

This study follows 432 golfers who have hip, knee, or shoulder replacement surgery to see when and how they return to golf. Participants are active golfers who want to play again after surgery. The goal is to learn about the recovery process, not to test a new treatment.

This pilot study tests two different exercise programs in 20 people with knee osteoarthritis to see how cartilage responds. One group exercises with rest breaks, the other without. The goal is to understand the mechanical and molecular effects of exercise on cartilage, not to tre…

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This study is testing whether special insoles that measure how you walk can predict your recovery after knee replacement surgery. 200 adults with knee osteoarthritis will wear the insoles before surgery and complete questionnaires about their symptoms. Researchers will use comput…

This study aims to find out how many people with knee osteoarthritis also have nerve-related pain, and whether that type of pain makes their symptoms and daily function worse. Researchers will measure pain and physical ability in 102 participants using standard questionnaires. Th…

This observational study looks at hip and knee tissue from 1000 adults with osteoarthritis who are scheduled for joint replacement surgery. Researchers want to measure levels of rare metals and immune markers in the joint tissue and blood. The goal is to find imbalances that coul…

This study looks at how often people can return to sports at least three years after total knee replacement. It compares three different types of knee prostheses to see if one type leads to better sports participation. The study will include 660 adults who had their first knee re…

This study looks at whether the Iowa Level of Assistance (ILoA) scale is a reliable tool for measuring functional recovery in patients after joint replacement surgery. Researchers will have multiple physiotherapists assess the same patients to see if their scores agree. The goal …

This study is observing 650 people with osteoarthritis who receive cell therapy or other treatments. Researchers aim to assess how well cell therapy works by using a questionnaire. The study is currently recruiting participants.

This study looks at how well a particular type of knee replacement works in 960 adults who had surgery between 2013 and 2024. Researchers will check knee function and X-ray results at least one year after surgery. The goal is to see how the prosthesis performs and compare it to o…

This study aims to create and test an Italian version of a standard knee questionnaire, the New Knee Society Knee Scoring System. Researchers will translate the English survey into Italian, check its accuracy, and then ask about 300 Italian patients with knee osteoarthritis to fi…

This study aims to create a model that predicts how long patients will need inpatient rehabilitation after hip or knee replacement for osteoarthritis. Researchers will collect data from 400 patients to validate the model. The goal is to personalize care and improve quality of lif…

This observational study at Shanghai Geriatric Medical Center looks at how the anesthetic drug ciprofol behaves in 50 older adults (65+) undergoing limb surgery. Researchers will collect blood samples and monitor vital signs to build a model that could help doctors adjust doses m…

This study looks at whether malnutrition changes how well older adults recover after shoulder surgery when they use virtual reality (VR) for rehabilitation. Researchers will track 60 frail adults aged 60+ to see if poor nutrition limits the benefits of VR therapy. The goal is to …

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study is testing whether a smart knee implant that tracks movement like steps and walking speed can help people recover better after knee replacement surgery. Researchers will also see if the device can reduce the number of follow-up clinic visits. About 150 adults having kn…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will give a single injection of oxytocin or a placebo to 38 people (some with knee arthritis, some healthy) and measure tiny changes in pupil…

This study looks at whether having total knee replacement surgery as an outpatient (going home the same day) leads to better recovery compared to staying in the hospital. Researchers will review medical records of 440 patients who had knee replacement between 2020 and 2023 at a F…

This study tests a new tool to help surgeons balance knee ligaments during total knee replacement. The goal is to see if the tool makes the procedure more accurate and repeatable. About 40 adults with knee arthritis will take part. The study focuses on measuring how much the liga…