One dose before surgery: could methadone ease knee replacement pain?

NCT ID NCT07485803

Recruiting now Symptom relief Sponsor: AdventHealth Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive methadone or not. Researchers will track opioid use for 48 hours after surgery and measure pain levels using standard scales.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: methadone
What this could lead to: If it works, this could offer a simple, single-dose way to better manage pain after knee replacement and reduce the need for other opioids.
What could go wrong: This is a small, early-phase study (Phase 4) with 192 participants, so results may not apply to everyone. Methadone itself is an opioid and carries risks like respiratory depression or addiction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

AdventHealth Porter
RECRUITING

Denver, Colorado, 80210, United States

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