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Can a new Slow-Release ibuprofen tame knee arthritis pain for 12 hours?

NCT ID NCT05318521

Ongoing Symptom relief Sponsor: Overseas Pharmaceuticals, Ltd. Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether an 800 mg modified-release ibuprofen tablet can reduce chronic knee pain from osteoarthritis better than a placebo. About 500 adults with knee osteoarthritis will take either the long-acting ibuprofen or a placebo daily for 12 weeks. Researchers will measure changes in pain, stiffness, and physical function using standard questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a new long-acting ibuprofen tablet (800 mg modified-release)
What this could lead to
If it works, this could offer people with knee osteoarthritis a longer-lasting pain reliever that requires fewer daily doses.
What could go wrong
This is an early-phase trial comparing the drug to a placebo, so it is not yet proven to work. Ibuprofen can cause stomach, kidney, or heart side effects, especially with long-term use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE ARTHRITIS

Contacts and locations

Locations

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Coastal Carolina Research Center

    North Charleston, South Carolina, 29405, United States

  • Core Healthcare

    Cerritos, California, 90703, United States

  • Cvillemedresearch

    Charlottesville, Virginia, 22911, United States

  • National Institute of Clinical Research

    Garden Grove, California, 92844, United States

  • Palm Beach Research Center

    West Palm Beach, Florida, 33409, United States

  • Paragon Rx Clinical, Inc.

    Santa Ana, California, 92703, United States

  • Taipei Medical University Hospital

    Taipei, 11031, Taiwan

  • Taipei Medical University Shuang Ho Hospital

    New Taipei City, 23561, Taiwan

  • Taipei Municipal Wanfang Hospital

    Taipei, 11696, Taiwan

  • Well Pharma Medical Research

    Miami, Florida, 33173, United States

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