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Can a pinch of hydromorphone make knee surgery recovery less painful?

NCT ID NCT07722234

Completed Symptom relief Sponsor: China-Japan Friendship Hospital Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether adding a small dose of hydromorphone to a standard numbing medicine (ropivacaine) improves pain control after total knee replacement. About 90 adults undergoing knee surgery will receive either the combination or the numbing medicine alone via a nerve block. Researchers will measure pain scores and muscle strength over the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a combination of hydromorphone and ropivacaine given as a nerve block
What this could lead to
If effective, this combination could provide longer-lasting pain relief after knee replacement, reducing the need for other painkillers.
What could go wrong
This is a small, early-stage trial. Adding an opioid may increase side effects like nausea or drowsiness without significantly improving pain control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

QUADRICEPS STRENGTH VAS SCORE

Contacts and locations

Locations

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.