Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a pinch of hydromorphone make knee surgery recovery less painful?

NCT ID NCT07722234

Symptom relief Sponsor: China-Japan Friendship Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 28, 2026 · Updated 3 times

Summary

This trial tests whether adding a small dose of hydromorphone to a standard numbing medicine (ropivacaine) improves pain control after total knee replacement. About 90 adults undergoing knee surgery will receive either the combination or the numbing medicine alone via a nerve block. Researchers will measure pain scores and muscle strength over the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a combination of hydromorphone and ropivacaine given as a nerve block
What this could lead to
If effective, this combination could provide longer-lasting pain relief after knee replacement, reducing the need for other painkillers.
What could go wrong
This is a small, early-stage trial. Adding an opioid may increase side effects like nausea or drowsiness without significantly improving pain control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Mar 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. ASA physical status I-III; 2. Undergoing elective unilateral primary total knee arthroplasty (TKA); 3. Implementing the ERAS protocol 4. Body-mass index (BMI) of 18.5-32.0 kg/m²; 5. Provided written informed consent. Exclusion Criteria: 1. Allergy to amide local anaesthetics or opioids; 2. Chronico or disorder opioid use; 3. Pre-existing central and peripheral nerve injuries； 4. Lower limb muscle weakness 5. Unable to cooperate with VAS pain assessment 6. Contraindications for nerve block include infection at the puncture site.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Osteoarthritis of the knee are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Quadriceps strength Vas score

Contacts and locations

Locations

  • China-Japan Friendship Hospital

    Beijing, Beijing Municipality, 100029, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.