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Can a steroid cocktail beat the standard nerve block for knee replacement pain?

NCT ID NCT05736549

Recruiting now Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial compares two types of nerve blocks for pain control after bilateral total knee replacement. One combines a standard numbing medication with two steroids, the other uses a long-acting liposomal bupivacaine. Researchers want to see if the steroid-enhanced block provides better pain relief and reduces the need for opioids in the days after surgery. About 66 adults scheduled for double knee replacement will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a steroid-enhanced nerve block combining bupivacaine, dexamethasone sodium phosphate, and methylprednisolone acetate
What this could lead to
If it works, this could offer a longer-lasting, more effective pain relief option for people undergoing double knee replacement, potentially reducing opioid use.
What could go wrong
This is a small Phase 2 trial, so results may not apply broadly. Steroid injections near nerves carry rare risks of nerve damage or infection.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE ARTHROPLASTY TOTAL KNEE REPLACEMENT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Yale New Haven Hospital Saint Raphael Campus

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Yale New Haven Hospital York Street Campus

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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