Adventhealth

This study tracks how well a device called the DAT clip works during routine endoscopy to stop bleeding, close perforations (holes), or treat fistulas (abnormal connections) in the digestive tract. Researchers will record data from 250 adults who need this clip as part of their s…

This study looks at whether delivering chemotherapy directly into the liver through a small implanted pump can help people with pancreatic or duodenal adenocarcinoma that has spread to the liver after surgery and standard chemotherapy. Participants receive floxuridine through the…

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This early-phase trial is testing whether a combination of two hormone-blocking drugs (darolutamide and relugolix) can safely shrink high-risk prostate tumors before they are surgically removed. About 30 men with aggressive prostate cancer will take the drugs for a short time bef…

This study will follow 600 adults who are already scheduled to receive a standard procedure called POEM, which uses a scope to cut tight muscles in the throat or stomach. The goal is to see how well the procedure works over time for conditions like achalasia, gastroparesis, and Z…

This study compares two methods used during colonoscopy to remove large, flat colon polyps: marking the edges before removal or using heat to treat the edges after removal. The goal is to see which method better prevents polyps from growing back. About 342 adults with polyps 20 m…

This study tests a community-based program to help underserved adults get screened for breast, lung, and prostate cancers. Researchers will work with local resource spots to offer screenings and follow-up care. The goal is to see if this approach increases screening rates and cat…

Very preterm infants fed donor breast milk can run low on iron because donor milk has less of it than formula or fortified feeds. This trial tests whether starting an oral iron supplement earlier, once an infant tolerates 80 ml of milk per kilogram per day instead of waiting for …

This study tests a 5-month workshop series called PREP designed to help newly licensed nurses manage stress and feel more prepared for work. Researchers will measure changes in psychological well-being and work readiness in 212 nurse residents. The goal is to see if emotional pre…

This study compares two procedures to treat stomach blockage caused by cancer: a newer method using an endoscope (EUS-GJ) and traditional surgery (S-GJ). The goal is to see which is safer and works better. About 70 adults with advanced cancer will take part.

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This study tests whether a whole-food, plant-based diet (no added oils) can reduce painful diabetic neuropathy better than standard medication. Forty adults with type 2 diabetes and nerve pain will be randomly assigned to either the diet or medication optimization. The main goal …

This study tests whether a 4-week digital brain-training program can reduce apathy (lack of motivation) in older adults with depression. Researchers will measure changes in brain scans and apathy scores. The goal is to see if this non-drug approach can improve brain function and …

This study looks at robotic telesurgery, where a surgeon performs prostate surgery on a patient in a different location using a secure internet connection. Researchers want to learn how safe and workable the Microport Medbot Robotic Platform is in real hospitals, and what technic…

This registry study is tracking 1,000 adults who are scheduled to undergo endoscopic submucosal dissection (ESD), a procedure that removes deep tumors from the digestive tract without major surgery. Researchers want to see how well ESD works in a Western population, measuring thi…