Can a single steroid dose transform knee replacement recovery?

NCT ID NCT05018091

Completed Symptom relief Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial compares three doses of dexamethasone (4 mg, 8 mg, and 16 mg) given during total knee replacement surgery to see which one best reduces pain, opioid use, and nausea after the operation. Adults having a primary knee replacement and staying at least one night in the hospital are eligible. The study measures opioid consumption and pain scores over the first 48 hours, along with nausea and blood sugar levels, to find the safest and most effective dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexamethasone, a corticosteroid given intravenously during surgery
What this could lead to: If successful, this could identify the optimal dexamethasone dose to improve recovery after knee replacement, reducing pain and opioid use.
What could go wrong: The trial is testing different doses, and higher doses may increase risks like blood sugar spikes. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

Columbia University Irving Medical Center

New York, New York, 10032, United States
Jefferson Philadelphia University and Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Mass General Brigham

Somerville, Massachusetts, 02145, United States
Mayo Clinic Institutional Review

Rochester, Minnesota, 55902, United States
NYU Langone Health

New York, New York, 10016, United States
Rush University medical Center

Chicago, Illinois, 60612, United States
Stanford University

Redwood City, California, 94063, United States
University of California, San Francisco

San Francisco, California, 94158, United States
University of Pennsylvania Perelman School of Medicine

Philadelphia, Pennsylvania, 19104, United States
Washington University

St Louis, Missouri, 63110, United States

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