TOTAL KNEE ARTHROPLASTY

After knee or hip surgery, some people struggle to fully activate their muscles due to a condition called Arthrogenic Muscle Inhibition (AMI). This trial tests whether a brain-computer interface that provides real-time neurofeedback during visualization exercises can improve musc…

This study tests whether taking branched-chain amino acid (BCAA) supplements for three months after knee replacement surgery can help improve muscle mass and strength in patients with sarcopenia (age-related muscle loss). About 140 adults aged 40 to 100 will be randomly assigned …

This study tests three ways to give the antibiotic vancomycin during knee replacement surgery: into the joint, into the bone, or through a vein. The goal is to see if the simpler joint injection works as well as the others to prevent serious infections. Thirty adults having a fir…

This study compares two types of knee implants (medial congruent vs. posterior stabilized) in people having total knee replacement for arthritis. All surgeries will be done with the ROSA robotic system. Researchers will track 200 participants for up to 5 years to see which implan…

This study compares two types of robotic-arm assisted knee replacement surgery in 120 people with knee osteoarthritis. One group gets cementless implants, the other gets cemented implants. The main goal is to see which approach helps patients 'forget' they have an artificial knee…

This study tests an experimental drug called BT-114143 to see if it can reduce blood loss during knee replacement surgery better than a standard treatment. About 270 adults with osteoarthritis who need a knee replacement will take part. Participants will receive either a high or …

This study is testing whether giving one dose of methadone just before total knee replacement surgery can help control pain afterward and reduce the amount of other painkillers needed. About 192 adults aged 21-75 having a knee replacement will be randomly assigned to receive meth…

This pilot study tests whether a video-based prehabilitation program—including education, stress management, and physical activity coaching—can help people prepare for total knee replacement surgery. Forty adults scheduled for knee replacement will either receive this program or …

This study tests two different nerve blocks to see which one works better for pain control after total knee replacement. Sixty adults having knee surgery will be randomly assigned to receive one of the blocks along with standard pain medicines. The goal is to reduce the need for …

This study tests whether a compressive cryotherapy device (Game Ready®) can reduce the need for opioid painkillers after total knee replacement surgery. About 74 adults aged 60-80 will be randomly assigned to use either the device or traditional ice packs four times daily for a w…

This study tests whether a new nerve block (quadri-block) helps people recover better after total knee replacement compared to the usual method (adductor canal block plus surgical infiltration). One hundred adults with knee arthritis scheduled for knee replacement will be randoml…

This study follows 270 adults having knee replacement surgery to see if the steroid dexamethasone (given as a pill or through a vein) helps with early recovery. Researchers will measure pain, mobility, nausea, and need for extra painkillers. The study does not assign treatments—p…

This study tests two different ways to numb the back of the knee after total knee replacement surgery. Both methods are combined with a standard front-of-thigh block. The goal is to see which approach leads to better overall recovery, less pain, and less need for strong painkille…

This study compares two types of nerve blocks to control pain after total knee replacement. 78 adults will receive one of two combinations of ultrasound-guided injections near the knee. The goal is to see which approach reduces pain and the need for opioid painkillers in the firs…

This study tests whether listening to binaural beats or a patient's chosen music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. About 50 adults having these surgeries will take part. Researchers will measure pain and anxiety levels right after su…

This study tests whether a short course of the steroid methylprednisolone, taken as pills after knee replacement surgery, can reduce pain, opioid use, and nausea. About 420 adults having knee replacement for osteoarthritis will receive either the steroid or a placebo. The goal is…

This study compares two types of nerve blocks—femoral triangle block and adductor canal block—given during knee replacement surgery. The goal is to see which one better preserves early leg muscle function and helps patients move sooner. About 136 adults undergoing knee replacemen…

This study compares two types of nerve blocks for pain after total knee replacement. One method uses a combination of adductor canal and iPACK blocks, the other uses a suprainguinal fascia iliaca block. The goal is to see which provides better pain control, reduces opioid use, an…

This pilot study tests whether wearing a knee extension brace for the first 72 hours after total knee replacement can reduce pain and improve recovery. 106 participants will be randomly assigned to either the brace or standard care with early movement. The main goal is to see if …

This study tests whether freezing certain nerves (cryoablation) during total knee replacement surgery can reduce pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or sur…

This study tests a new clinical decision support tool that helps physical therapists tailor rehabilitation for veterans after total knee replacement. Instead of a one-size-fits-all approach, the tool uses each patient's recovery data to personalize therapy. The goal is to improve…

This pilot study looks at whether a new wheeled mobility tool helps people move around more easily after total knee replacement. About 19 adults aged 18-99 who can walk with at most a cane or crutch before surgery will use the device. Researchers will track how much they use it a…

This study tests whether wearing noise-cancelling headphones with music or a movie can help people stay calm and need less sedation during knee replacement surgery done under spinal anesthesia. About 200 adults having their first knee replacement will take part. The goal is to se…

This study tests whether teaching patients about nutrition and following a specific fasting plan before knee replacement surgery can help reduce thirst, nausea, and vomiting afterward. About 72 adults having knee replacement will be split into two groups: one gets the special edu…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This study looks at 102 adults having knee replacement surgery to find the best nerve block for pain relief. The standard block helps with front knee pain but not back-of-knee pain. Researchers will compare three extra blocks—sciatic nerve, BiFeS, and IPACK—to see which one works…

This study tests whether taking GlyNAC (a mix of two natural amino acids) before and after knee replacement surgery can reduce chronic pain. 148 adults with knee osteoarthritis will take either GlyNAC or a placebo for 4 weeks before surgery and 6 weeks after. Researchers will tra…

This study tests three different doses of a long-acting numbing medicine (liposomal bupivacaine) injected into a nerve block in the thigh to control pain after total knee replacement. About 177 adults having robotic knee surgery will be randomly assigned to receive one of the dos…

This study tests whether using mild electrical pulses on the thigh muscle can help people regain strength and movement faster after total knee replacement. About 3,250 patients will be randomly assigned to receive either standard physical therapy or standard therapy plus electric…

This study tests whether a special navigation system (NextAR) helps surgeons better balance the soft tissues during total knee replacement. The goal is to make the new knee feel more natural so patients can forget about it. About 100 adults with severe knee arthritis will be rand…

This pilot study tests a new pain-numbing injection called IPSA, given by the surgeon directly into the back and inner side of the knee during total knee replacement. 60 adults undergoing knee replacement will be randomly assigned to receive either the new IPSA block plus standar…

This study looks at whether people aged 70 and older experience changes in thinking skills, like attention and processing speed, after same-day hip or knee replacement surgery. About 48 participants will take a short cognitive test before surgery and again on the first and sevent…

This pilot study is testing how much irrigation fluid is needed to clear contaminants during revision knee replacement surgery for infection. Surgeons will apply a blue dye to the knee joint and wash it out in measured steps until the dye is gone. The goal is to gather data to de…

This study is testing whether special insoles that measure how you walk can predict your recovery after knee replacement surgery. 200 adults with knee osteoarthritis will wear the insoles before surgery and complete questionnaires about their symptoms. Researchers will use comput…

This study is testing whether a smart knee implant that tracks movement like steps and walking speed can help people recover better after knee replacement surgery. Researchers will also see if the device can reduce the number of follow-up clinic visits. About 150 adults having kn…