TOTAL KNEE ARTHROPLASTY

This study tests an experimental drug called BT-114143 to see if it can reduce blood loss during knee replacement surgery better than the current standard treatment. About 270 adults having knee replacement will receive either a high or low dose of BT-114143 or tranexamic acid. T…

This study tests whether whole-body vibration therapy can help bone health and physical function in women with low bone density (osteopenia) after total knee replacement. 48 women will be split into three groups: vibration alone, vibration with exercise, or standard rehab. The go…

This study tests whether taking a combination of two natural antioxidants (glycine and N-acetyl-cysteine, or GlyNAC) before and after knee replacement surgery can reduce the risk of long-term chronic pain. About 148 adults aged 50 and older with knee osteoarthritis will be follow…

This study tests whether wearing a knee brace for the first 3 days after total knee replacement can reduce pain and help recovery. About 106 adults having knee surgery will either wear the brace or follow standard care. The goal is to see if this simple approach is practical and …

This study tests whether using personalized soft tissue balance data from the NextAR navigation system during knee replacement surgery helps patients feel more like their knee is natural. 100 adults with severe knee arthritis will be randomly assigned to receive either standard s…

This study compares two types of robotic-assisted total knee replacement surgery for people with knee osteoarthritis. One method uses cement to fix the new joint in place, while the other does not. The goal is to see which approach helps patients feel more like their knee is natu…

This study tests whether wearing noise-cancelling headphones with music or a movie can help people stay calm and need less sedation during knee replacement surgery done with spinal anesthesia. About 200 adults having their first knee replacement will take part. The goal is to see…

This study compares two types of nerve blocks to control pain after total knee replacement surgery. About 52 adults having knee replacement will receive either a combination of adductor canal and iPACK blocks or a suprainguinal fascia iliaca block. The goal is to see which method…

This study tests a new tool that helps physical therapists create personalized recovery plans for veterans after knee replacement surgery. Instead of a one-size-fits-all approach, the tool tailors therapy based on each person's needs and goals. The goal is to improve how well vet…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement can lower pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or surgery plus…

This study tests whether a continuous pain-relief catheter placed in the thigh works better than a single injection to reduce opioid painkiller use after total knee replacement. About 64 adults scheduled for knee surgery will be randomly assigned to receive either the catheter or…

This study tests a new way to numb pain during knee replacement surgery. Doctors will inject a long-lasting anesthetic directly into the back and inner side of the knee joint. About 60 adults having knee replacement will be randomly assigned to one of three pain-blocking methods.…

This study tests whether listening to binaural beats (special sound patterns) or your favorite music for 30 minutes after knee or hip replacement surgery can lower pain and anxiety. Fifty adults having outpatient joint replacement will be randomly assigned to one of the two sound…

This study compares two different nerve block methods (iPACK and BiFeS) for pain relief after total knee replacement surgery. 74 adults having knee replacement will receive one of the two blocks along with a standard adductor canal block. The goal is to see which approach leads t…

This study compares two types of nerve blocks (femoral triangle block and adductor canal block) to see which one helps people regain leg strength sooner after total knee replacement. About 136 adults having knee surgery will be randomly assigned to receive one of the blocks, plus…

This study compares three types of nerve blocks (sciatic, BiFeS, and IPACK) added to a standard block for pain after total knee replacement. The goal is to find which combination provides the best pain relief while preserving leg strength for early movement. About 102 adults unde…

This study looks at whether teaching patients about nutrition and following a specific fasting plan before knee replacement surgery can help reduce thirst, nausea, and vomiting after the operation. About 72 adults having knee replacement will be split into two groups: one gets th…

This study tests whether different doses of a long-lasting numbing medicine (liposomal bupivacaine) can better control pain after total knee replacement. About 177 adults having robotic knee surgery will receive the medicine in a nerve block. The goal is to find the best dose to …

This study looks at how a new wheeled mobility tool helps people move around after total knee replacement surgery. Researchers will track how much patients use the device and measure their pain and knee function over three months. The goal is to see if the tool improves recovery …

This study tests whether using gentle electrical pulses on the thigh muscle can help people regain leg strength and movement faster after total knee replacement. About 3,250 patients will be randomly assigned to receive either standard physical therapy or standard therapy plus el…

This study compares two pain-blocking techniques for people having knee replacement surgery. The goal is to see which method better reduces pain and the need for strong painkillers after the operation. About 78 adults will take part, and their pain levels and recovery will be tra…

This study tests whether a short course of the steroid methylprednisolone, taken as pills after knee replacement surgery, can reduce pain, the need for strong painkillers, and nausea. About 420 adults having their first knee replacement will be randomly assigned to receive either…

This study looks at three methods of giving the antibiotic vancomycin during total knee replacement surgery: into the joint, into the bone, or through a vein. The goal is to see which method delivers the most antibiotic to the tissues that need it most, to prevent serious infecti…

This study looks at how much fluid surgeons need to use to fully clean an infected artificial knee joint during a special surgery called DAIR. About 20 adults with knee replacements and infections will take part. Doctors will use a blue dye to track contamination and take photos …

This study looks at whether special insoles that measure how you walk, along with other health information, can predict how much your knee will improve after replacement surgery. About 200 adults with knee osteoarthritis scheduled for surgery will participate. The goal is to help…

This study looks at how a person's neighborhood resources affect their recovery after knee replacement surgery. Researchers will use a remote monitoring device to track physical progress and compare it to standard care. The goal is to see if remote monitoring can reduce the numbe…