Knee replacement patients may avoid long-term pain with antioxidant supplement

NCT ID NCT06083480

Recruiting now Symptom relief Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking GlyNAC (a mix of two natural amino acids) before and after knee replacement surgery can reduce chronic pain. 148 adults with knee osteoarthritis will take either GlyNAC or a placebo for 4 weeks before surgery and 6 weeks after. Researchers will track pain levels for a year to see if the supplement lowers oxidative stress and prevents long-term pain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GlyNAC (a combination of the amino acids glycine and N-acetylcysteine)
What this could lead to: If it works, this could point toward a simple, low-cost supplement to prevent long-term pain after knee replacement surgery.
What could go wrong: This is a small, early-phase trial (148 people) testing a supplement, not a drug. The effect may be modest or no better than placebo, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC POSTSURGICAL PAIN OSTEOARTHRITIS, KNEE TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37212, United States

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