Knee replacement patients may avoid long-term pain with antioxidant supplement
NCT ID NCT06083480
First seen Jan 04, 2026 · Last updated Jun 22, 2026 · Updated 35 times
Summary
This study tests whether taking GlyNAC (a mix of two natural amino acids) before and after knee replacement surgery can reduce chronic pain. 148 adults with knee osteoarthritis will take either GlyNAC or a placebo for 4 weeks before surgery and 6 weeks after. Researchers will track pain levels for a year to see if the supplement lowers oxidative stress and prevents long-term pain.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37212, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GlyNAC (a combination of the amino acids glycine and N-acetylcysteine)
What this could lead to
If it works, this could point toward a simple, low-cost supplement to prevent long-term pain after knee replacement surgery.
What could go wrong
This is a small, early-phase trial (148 people) testing a supplement, not a drug. The effect may be modest or no better than placebo, and results may not apply to everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.