OSTEOARTHRITIS, KNEE

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifesty…

This study is testing the Persona knee implant in 760 people who need total knee replacement due to arthritis or other knee conditions. The goal is to see if the implant is safe and improves knee function and quality of life. Participants will be followed for several years after …

This study tests whether stem cells from umbilical cords can help people with knee osteoarthritis. Sixty participants will receive either a low or high dose of these cells injected into the knee joint. The goal is to see if the treatment is safe and can reduce pain and improve kn…

This study compares two knee surgeries for people with knee osteoarthritis, a meniscus problem, and a misaligned leg. Half the participants will get a standard realignment surgery, and the other half will get that plus a donor meniscus transplant. The goal is to see if the combin…

This study is testing a new computer navigation system (OrthoPilot with pheno4u software) to help surgeons perform knee replacements more accurately. About 120 people who need a total knee replacement will take part. The goal is to see if the new software improves how well the im…

This early study tests a single injection of cells made from donor gum tissue into the knee joint of 15 people with knee osteoarthritis. The main goal is to see if it is safe, but researchers will also check for pain relief and better knee function. The cells have shown anti-infl…

This study tests whether exosomes—tiny particles from stem cells—can help people with knee osteoarthritis. Twenty adults with mild to moderate knee arthritis will receive two injections of these exosomes into the knee joint. Researchers will measure changes in pain and knee funct…

This study is testing whether a smartphone app can detect early knee osteoarthritis by measuring how the knee moves during simple activities like walking. Researchers will compare the app's results to standard motion-capture equipment and patient symptoms. If it works, this could…

This Stanford study tests whether people with knee osteoarthritis can learn to change how they activate their calf muscles while walking, using a vibrating feedback device. The goal is to reduce the force on the knee joint. Thirty-one participants will train on a treadmill or ove…

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a fl…

This study tests whether low-dose radiotherapy can reduce pain in people with knee osteoarthritis. 128 participants will receive either real radiation or a sham treatment three times a week for two weeks. Researchers will track pain scores and painkiller use for six months to see…

This study tests whether a compressive cryotherapy device (Game Ready®) can reduce the need for opioid painkillers after total knee replacement surgery. About 74 adults aged 60-80 will be randomly assigned to use either the device or traditional ice packs four times daily for a w…

This study tests a device called the MISHA Knee System, a small implant placed under the skin near the knee to absorb shock and reduce pain from medial knee osteoarthritis. Researchers will compare it to non-surgical treatments like physical therapy and medication in 100 adults w…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This study compares two steroid injections for knee osteoarthritis in people with type 2 diabetes. It aims to see which one controls pain better while causing fewer blood sugar spikes. About 120 adults with diabetes and knee arthritis will receive either a long-acting or short-ac…

This study tests whether adding a mild electrical current (interferential current) to a standard exercise program can further reduce pain and improve function in people with knee osteoarthritis. 138 adults aged 40-75 with knee pain will be split into three groups: exercise only, …

This study compares two approaches to recovery after total knee replacement: a fast track plan designed to speed up recovery versus standard care. Researchers will measure how well patients can move and care for themselves after surgery, as well as how long they stay in the hospi…

This study looks at whether adding a special education program about chronic pain to standard exercise therapy can improve daily function and reduce pain in people with knee osteoarthritis. About 92 adults with knee OA will be randomly assigned to either exercise alone or exercis…

This study tests whether an injected drug called pentosan polysulfate sodium can reduce knee pain and improve function in people with knee osteoarthritis. About 466 adults with moderate to severe knee arthritis who haven't found relief from other treatments will receive either th…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study tests whether cannabidiol (CBD) can lower the need for opioid painkillers after knee replacement surgery. 380 adults with knee osteoarthritis will take CBD or a placebo before and after surgery. Researchers will measure total opioid use and pain over 28 days to see if …

This study compares two types of computer-assisted knee replacement surgery: one using a navigation system (OrthoPilot) and one using a robotic arm (MAKO). The goal is to see if they provide similar improvements in knee function and pain relief one year after surgery. About 140 a…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This study is testing whether low-impact group exercise classes can help reduce pain in people with knee, hip, or ankle osteoarthritis. Participants attend one-hour group sessions three times a week for six months, led by a physical therapist or trainer. The study also includes s…

This study tests whether adding probiotic supplements to standard treatment can reduce pain, stiffness, and improve daily function in people with knee osteoarthritis. About 146 adults with symptomatic knee OA will take probiotics or a placebo for a set period. The goal is to see …

This study tests two approaches to help people with knee osteoarthritis stay active after physical therapy: a game-like reward system with social support, and health coaching. About 254 veterans will use a Fitbit and smartphone app to track their progress. The goal is to see if t…

This study tests whether nurse-led telehealth visits can detect complications and support recovery as well as in-person visits after total knee replacement. About 98 adults who had their first knee replacement will receive follow-up care either through a mobile app or at the clin…

This study tests whether injecting a person's own bone marrow cells or a mix of fat cells and platelet-rich plasma into the knee can reduce pain from osteoarthritis. About 148 adults with moderate knee arthritis will receive either the real treatment or a placebo (salt water) inj…

This study tests whether taking GlyNAC (a mix of two natural amino acids) before and after knee replacement surgery can reduce chronic pain. 148 adults with knee osteoarthritis will take either GlyNAC or a placebo for 4 weeks before surgery and 6 weeks after. Researchers will tra…

This pilot study tests whether a culturally tailored program of muscle strengthening exercises and physical activity, delivered via video calls, can help Hispanics with knee osteoarthritis. Participants bring a family member or close friend for support. The study will measure how…

This study tests whether taking cannabidiol (CBD) extract under the tongue three times a day can safely ease knee osteoarthritis pain and reduce the need for NSAID painkillers. Thirty adults with moderate to severe knee pain will receive either CBD or a placebo for several weeks.…

This study compares robotic-assisted total knee replacement to the standard manual procedure in 86 adults aged 40-85 with severe knee arthritis. Participants will receive the same knee implant, but one group's surgery is guided by a robotic system. Researchers will measure pain, …

This phase 2 trial is testing whether daily doses of THC, CBD, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 participants will take one of the study drugs or a placebo for 16 weeks, with regular pain assessments, blood tests, and brain…

This study looks at two different methods of placing a total knee prosthesis: mechanical alignment (standard, fixed angles) and kinematic alignment (customized to each patient's anatomy). Researchers want to see which technique leads to better knee movement and function during ac…

This study compares two ways of closing the wound after hip or knee replacement surgery: barbed sutures (a newer type) versus conventional sutures. About 90 adults having hip or knee replacement will be randomly assigned to one method. Researchers will track wound healing, compli…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will give a single injection of oxytocin or a placebo to 38 people (some with knee arthritis, some healthy) and measure tiny changes in pupil…