OSTEOARTHRITIS, KNEE

This early-stage study tests a single injection of ICM-203, a gene therapy designed to help regrow cartilage and reduce pain and inflammation in the knee. It involves 18 adults with mild to moderate knee osteoarthritis. The main goals are to check safety and see if the treatment …

This study tests a program called BOOST-OA to help veterans with knee osteoarthritis stay on track with home exercises prescribed by their physical therapist. The program includes goal-setting tools and health coaching calls over 12 months. Researchers will measure whether it imp…

This study compares robotic-assisted knee replacement to the traditional manual method in 170 adults aged 50-80 with severe knee osteoarthritis. The goal is to see if robotic surgery leads to better knee function, faster recovery, and lower costs. Participants will be followed fo…

This study compares robotic-assisted knee replacement surgery to the standard manual procedure for people with knee osteoarthritis. About 346 adults will be randomly assigned to one of the two surgeries and followed for a year to see which provides better pain relief, function, a…

This study compares a single injection of hyaluronic acid to a series of three weekly injections for people with knee osteoarthritis. The goal is to see if the single shot works just as well for pain relief and knee function, while being more convenient. Forty-six adults with mod…

This study looks at whether cooling the knee after total knee replacement surgery can reduce pain and help people recover faster. About 99 adults having knee replacement will be randomly placed into one of three groups: cooling with a special bandage, cooling with an ice pack, or…

This study compares a new tablet called Laybon to an existing one (Layla) for knee osteoarthritis pain. About 172 adults aged 40 to 80 with knee arthritis will take either Laybon or Layla for 8 weeks. The main goal is to see if Laybon works as well as Layla at reducing knee pain …

This study looks at whether a community-based program combining water exercise and peer support is practical for adults on a knee replacement waiting list. 48 participants will either receive usual NHS care or usual care plus the 6-week Good Boost+ program, which includes weekly …

This study looks at whether the bacteria in your gut can influence how well a knee replacement works. Researchers will compare the gut bacteria of 30 people with successful knee replacements to those who need a second surgery. The goal is to understand if differences in gut bacte…