OSTEOARTHRITIS, KNEE

This early-phase study tests a single injection of ICM-203, a gene therapy that delivers a gene to promote cartilage growth and reduce inflammation in the knee. About 18 adults with mild to moderate knee osteoarthritis will receive escalating doses to check safety and whether it …

This study compares robotic-assisted knee replacement to the traditional manual method in 170 adults aged 50-80 with end-stage knee arthritis. Participants are randomly assigned to one of the two surgeries and followed for 2 years to measure knee function, recovery speed, and cos…

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

This study looks at whether cooling the knee after total knee replacement surgery can help reduce pain and improve early recovery. About 99 adults having knee replacement will be randomly assigned to receive cooling with a special bandage, an ice pack, or standard care without co…

This study tests a program called BOOST-OA designed to help veterans with knee osteoarthritis stick to their home exercise routines. The program includes goal-setting tools during physical therapy and follow-up health coaching calls for 9 months after therapy ends. Researchers wi…

This study tests whether a new tablet called Laybon is as good as an existing drug (Layla) at reducing knee pain from osteoarthritis. About 172 adults aged 40-80 with knee osteoarthritis will take either Laybon or Layla twice daily for 8 weeks. The main goal is to see if knee pai…

This study looks at whether it's possible to run a larger trial of a community-based program called Good Boost+ for adults waiting for knee replacement surgery. The program includes weekly group water exercises and land-based exercises, plus peer support. Researchers will measure…

This study looks at whether the bacteria in your gut (the gut microbiome) is different in people whose knee replacements fail versus those whose knees work well. Researchers will compare gut bacteria in 30 patients needing repeat knee surgery to those with successful implants. Th…