OSTEOARTHRITIS, KNEE

This study tests whether stem cells from umbilical cords can safely help people with knee osteoarthritis. About 60 adults with moderate knee damage will receive the treatment. Researchers will use MRI scans and pain scores to see if the stem cells improve cartilage and reduce sym…

This study is testing a new knee implant (Persona) in 760 people who need knee replacement surgery due to arthritis or other knee problems. The goal is to see if the implant is safe, works well, and helps patients move better and feel less pain. Participants will be followed for …

This study compares knee realignment surgery alone versus realignment plus a donor meniscus transplant in 52 adults aged 20-60 with knee osteoarthritis and a missing meniscus. The goal is to see if the combined approach provides better pain relief, function, and joint protection.…

This study tests whether exosomes (tiny particles from stem cells) can help people with knee osteoarthritis. The goal is to reduce pain and improve knee function. Twenty adults with mild to moderate knee arthritis will receive the treatment and be monitored using a standard knee …

This study is testing a new computer navigation software for knee replacement surgery. The goal is to see if it helps surgeons place the new knee joint more accurately than the current system. About 120 people who need a knee replacement will take part, and their recovery and sat…

This early-stage study tests a single injection of cells from donated gum tissue into the knee joint of 15 people with knee osteoarthritis. The goal is to see if the treatment is safe and possible. The cells have shown anti-inflammatory and pain-relieving effects in animals.

This study tests if a smartphone app can measure knee movement to catch early knee osteoarthritis, a common problem in veterans. About 47 people with early knee OA will use the app while doing activities like walking and standing up. The goal is to see if this simple tool can hel…

This study tests whether taking a combination of two natural antioxidants (glycine and N-acetyl-cysteine, or GlyNAC) before and after knee replacement surgery can reduce the risk of long-term chronic pain. About 148 adults aged 50 and older with knee osteoarthritis will be follow…

This study compares two advanced techniques for total knee replacement: navigation-assisted surgery and robotic-assisted surgery. The goal is to see if one leads to better knee function and safety one year after the operation. About 140 adults with knee arthritis or similar joint…

This study is testing whether daily doses of CBD, THC, or both can reduce pain and improve symptoms in people with knee osteoarthritis. About 200 adults with moderate to severe knee pain for at least 6 months will be randomly assigned to receive one of the cannabinoid treatments …

This study is testing several experimental treatments to ease chronic pain from knee arthritis, diabetic nerve pain, or ongoing low-back pain. Researchers will compare each treatment against a placebo to see which ones work best. The trial aims to enroll 10,000 adults who have ha…

This study tests a new once-weekly injection (NNC0487-0111) to see if it helps people with excess weight and knee osteoarthritis lose weight and feel less knee pain. About 400 adults will receive either the study drug or a placebo for comparison. The main goals are to measure wei…

This study compares two types of knee replacement surgery: the standard method and a newer robotic-assisted technique. Researchers want to see if the robotic approach leads to better pain relief, movement, and overall function for people with severe knee arthritis. About 86 adult…

This study tests if an injected drug called pentosan polysulfate sodium can reduce knee pain and improve function in people with knee osteoarthritis. About 466 adults with knee pain that hasn't responded to other treatments will receive either the drug or a placebo over 6 weeks. …

This study explores whether people with knee osteoarthritis can learn to change how they use a specific calf muscle while walking, using a device that gives gentle vibrations as feedback. The goal is to reduce the force on the knee joint, which may help ease symptoms. About 31 pa…

This study tests whether nurse-led telehealth visits using a mobile app can detect complications and support recovery after total knee replacement surgery as effectively as traditional in-person clinic visits. About 98 adults who had their first knee replacement will be randomly …

This study tests a device called the MISHA Knee System to see if it reduces pain and improves function in people with knee osteoarthritis. About 100 adults who have not gotten relief from non-surgical treatments will be randomly assigned to receive the implant or continue with no…

This study tests a program designed to help Hispanics with knee osteoarthritis become more active. Participants pair up with a family member or close friend and receive live video sessions on exercise and education. The goal is to see if this approach improves exercise habits and…

This study tests two approaches to help people with knee osteoarthritis stay active after physical therapy. One uses gamification and social rewards through a smartphone app, and the other adds health coaching. The goal is to see if these methods improve exercise habits, reduce p…

This study tests whether adding probiotic supplements to usual care can reduce pain, stiffness, and improve daily activity in people with knee osteoarthritis. About 146 adults with knee OA will take probiotics or a placebo for a set period. The goal is to see if this simple addit…

This study looks at whether low-impact group exercise classes can help reduce pain in people with knee, hip, or ankle osteoarthritis. Participants will attend exercise classes three times a week for six months, along with standard diet and behavioral health support. The study wil…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study is testing whether cannabidiol (CBD) placed under the tongue can safely reduce knee pain from osteoarthritis and help people use fewer over-the-counter pain relievers like ibuprofen. Researchers will enroll 30 adults with moderate to severe knee pain. The goal is to se…

This study tests whether injections made from a person's own bone marrow or fat cells can reduce knee pain from osteoarthritis better than a placebo. About 148 adults with moderate knee arthritis will receive one of these cell injections or a dummy shot. Researchers will track pa…

This study tests whether taking cannabidiol (CBD) before and after knee replacement surgery can lower the amount of opioid painkillers people need. About 380 adults with knee osteoarthritis will receive either CBD or a placebo. The goal is to see if CBD can safely reduce opioid u…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a short-term anti-inflammatory drug only before planned walks to help with movement pain, while also learning about proper footwear and avoiding fear of movement. The goal is …

This study looks at whether injecting dexamethasone into a nerve block or giving it through an IV works better for pain and swelling after total knee replacement. About 90 adults over age 65 having knee surgery will be randomly assigned to one of the two methods. Researchers will…

This study looks at different ways to close the wound after hip or knee replacement surgery. About 90 adults having these surgeries will be randomly assigned to one of two closure methods. The goal is to see which method leads to better wound healing, fewer complications like inf…

This study looks at two different methods surgeons use to place a total knee replacement: mechanical alignment (a standard, one-size-fits-all approach) and kinematic alignment (a more personalized method that tries to match your original knee shape). The goal is to see which tech…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will measure tiny changes in pupil size after an injection of oxytocin or a placebo. The study includes 38 adults with knee arthritis or heal…