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Gum cell injection could ease knee arthritis pain

NCT ID NCT06690710

Recruiting now Disease control Sponsor: Scarcell Therapeutics S.A.S. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early study tests a single injection of cells made from donor gum tissue into the knee joint of 15 people with knee osteoarthritis. The main goal is to see if it is safe, but researchers will also check for pain relief and better knee function. The cells have shown anti-inflammatory and cartilage-repair effects in animals.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
allogeneic engineered gingival fibroblasts (aeGF) – donor gum cells
What this could lead to
If it works, this could point toward a new treatment that reduces pain and inflammation and possibly repairs cartilage in knee osteoarthritis.
What could go wrong
This is a very early, small Phase 1 trial with only 15 people, so safety and any benefit are uncertain. The cells are from donors, so immune reactions or lack of effect are possible risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Oxford University Hospitals NHS Foundation Trust (Nuffield Orthopaedic Centre, Oxford)

    RECRUITING

    Oxford, OX3 7LD, United Kingdom

    Contact Email: •••••@•••••

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