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Which knee implant moves best? trial puts three designs to the test

NCT ID NCT03895489

Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial compares three different knee replacement implants—Journey II, Stryker Triathlon, and Zimmer Persona—in people aged 50 to 75 with knee osteoarthritis. Researchers measure how well each implant restores knee movement, walking patterns, and function after surgery. The goal is to find out if one implant leads to better outcomes than the others.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
knee replacement implants (Journey II, Stryker Triathlon, Zimmer Persona)
What this could lead to
If one implant proves superior, it could guide surgeons toward a better option for knee replacement, improving mobility and reducing pain for patients.
What could go wrong
This is a small, early-stage trial with only 48 participants, so results may not apply to everyone. Differences between implants might be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

48 people

The number who actually took part.

Started

Sep 2019

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participant has signed an approved informed consent form. 2. Participant is a male or non-pregnant female and aged 50 to 75 years at the time of study device implantation. 3. Participant has a diagnosis of Non-Inflammatory Degenerative Joint Disease (NIDJD). 4. Participant is a candidate for a primary posterior-stabilized total knee replacement. 5. Participant is willing and able to comply with postoperative scheduled clinical and radiographic evaluations and rehabilitation. Exclusion Criteria: 1. Participant has a Body Mass Index (BMI) ≥ 40 kg/m2. 2. Participant has a varus or valgus deformity greater than 15º or flexion contracture greater than 20º or knee flexion range of motion \< 90º in either lower extremity. 3. Participant has an active or suspected latent infection in or about the affected knee joint at time of study device implantation. 4. Participant has received any orthopaedic surgical intervention to the lower extremities within the past 6 months or is expected to require any orthopaedic surgical intervention to the lower extremities, other than the TKA, within the next year. 5. Participant requires bilateral total knee replacements, or has a history of contralateral partial or total knee replacement within the past 6 months. 6. Participant has other medical conditions which limit the ability to evaluate the safety and efficacy of the device. 7. Participant requires revision surgery of a previously implanted total knee replacement or knee fusion to the affected joint. 8. Participant has a known sensitivity to device materials.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis,knee

Contacts and locations

Locations

  • Edmonton Bone and Joint Centre

    Edmonton, Alberta, T5E 5R8, Canada

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