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Can collagen supplements ease the deep pain of knee osteoarthritis?

NCT ID NCT07800780

Symptom relief Sponsor: Cihangir Türemiş Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether two different collagen supplements can reduce pain, stiffness, and disability in adults with knee osteoarthritis. Adults aged 35 to 65 with moderate knee osteoarthritis will take either a 10-gram hydrolyzed collagen, a 5-gram bioactive collagen peptide, or a placebo daily for 8 weeks. Neither participants nor researchers will know who gets which, to keep results unbiased. The study measures changes in pain, physical function, and quality of life using detailed questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two collagen supplements: 10g hydrolyzed bovine collagen peptide, or 5g lower-molecular-weight bioactive collagen peptide with maltodextrin, taken daily for 8 weeks
What this could lead to
If it works, this could point toward a simple daily supplement option for easing knee osteoarthritis pain and improving mobility and quality of life.
What could go wrong
This is a small, early-stage trial with 45 participants over 8 weeks, so results may not apply broadly. Collagen supplements may not outperform placebo for complex pain, and digestive upset is possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged between 35 and 65 years. * Clinical and radiographic diagnosis of primary knee osteoarthritis according to the American College of Rheumatology (ACR) criteria. * Radiographic severity of Kellgren-Lawrence grade 2 or 3 in the affected knee. * Experiencing chronic knee pain for at least the last 3 months. * Willingness to refrain from starting any new dietary supplements or physical therapy programs during the 8-week study period. * Ability to read, understand, and provide written informed consent, as well as independently complete the patient-reported outcome questionnaires. Exclusion Criteria: * Severe knee osteoarthritis (Kellgren-Lawrence grade 4) or mild/doubtful osteoarthritis (Kellgren-Lawrence grade 0-1). * History of intra-articular injections (corticosteroid, hyaluronic acid, PRP, stem cell, etc.) to the affected knee within the last 6 months. * Routine use of other joint health supplements (e.g., glucosamine, chondroitin, MSM, other collagen products) within the last 3 months. * History of major lower extremity surgery, major trauma, or previous ligament reconstruction (e.g., ACL reconstruction) on the affected knee. * Presence of systemic inflammatory joint diseases (e.g., rheumatoid arthritis, ankylosing spondylitis, gout). * Known allergy, hypersensitivity, or intolerance to bovine (beef) products or maltodextrin. * Current pregnancy or lactation. * Severe neurological, psychiatric, or cognitive disorders that would prevent accurate completion of the pain and central sensitization questionnaires.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis,knee

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Cesme Alper Cizgenakat State Hospital

    Izmir, 35950, Turkey (Türkiye)

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