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Weight loss and exercise may stop knee arthritis before it starts

NCT ID NCT05946044

Recruiting now Prevention Sponsor: Wake Forest University Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether a 48-month program of dietary weight loss, exercise, and weight maintenance can prevent knee osteoarthritis in women aged 50 and older who have obesity and no or infrequent knee pain. Participants are randomly assigned to the diet-and-exercise program or an attention control group. The study uses MRI scans to track changes in knee structure, and also measures pain, mobility, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a program of dietary weight loss, exercise, and weight-loss maintenance
What this could lead to
If successful, this could show that weight loss and exercise can prevent knee osteoarthritis in at-risk women, potentially reducing the need for joint replacements.
What could go wrong
This is a large but early-stage prevention trial. The intervention requires long-term commitment, and results may not apply to men or younger people. Weight regain or injury could affect outcomes.

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Conditions

The condition(s) this trial relates to.

Obesity osteoarthritis, knee prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of North Carolina at Chapel Hill

    ACTIVE_NOT_RECRUITING

    Chapel Hill, North Carolina, 27516, United States

  • University of Sydney

    RECRUITING

    Sydney, Australia

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Wake Forest University

    RECRUITING

    Winston-Salem, North Carolina, 27109, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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