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Which anesthesia gets joint replacement patients moving sooner?

NCT ID NCT05706844

Symptom relief Sponsor: Anders Troelsen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers compare spinal anesthesia and general anesthesia for people having hip or knee replacement surgery for osteoarthritis. The trial checks whether patients can safely walk 5 meters within 6 hours after surgery and how they feel in terms of pain, nausea, dizziness, confusion, and urinary retention. Participants are randomly assigned to one of the two anesthesia methods, and a physiotherapist evaluates their mobility after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Spinal anesthesia with bupivacaine or general anesthesia with propofol and remifentanil
What this could lead to
If one anesthesia method helps people walk sooner and feel better after joint replacement, it could guide anesthesia choices for these common surgeries.
What could go wrong
This is a single-center study of 222 people, so the results may not apply everywhere. Both anesthesia methods are standard and generally safe, but individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

222 people

The number who actually took part.

Started

Mar 2023

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Clinical and radiological hip or knee osteoarthritis meeting the indications for primary total hip, total knee, or unicompartmental knee arthroplasty. * ≥18 years of age. * Able to speak and understand Danish * Able to give informed consent and must be cognitively intact. Exclusion Criteria: * Lives in an institution. * Uses walking aid such as a walker or a wheelchair. * Terminal illness. * Has contraindications for either general or spinal anaesthesia. * Has objections to receiving either general or spinal anaesthesia. * Requires anxiolytics as premedication prior to anaesthesia. * Traumatic aetiology as a basis for surgical indication. * Altered pain perception and / or neurologic affection due to diabetes or other disorders. * Daily preoperative use of opioids \> 30 mg of morphine milligram equivalents (MME). * Standard primary arthroplasty procedure is evaluated not to be suitable. * Women considered fertile but without sufficient birth control.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, hip osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, hip Osteoarthritis, knee

Contacts and locations

Locations

  • Christian Bredgaard Jensen

    Hvidovre, 2650, Denmark

  • Vejle Hospital

    Vejle, 7100, Denmark

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