Could a single injection after knee surgery cut swelling in half?
NCT ID NCT07705165
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This trial tests whether an injection of tergase (berahyaluronidase alfa) can reduce swelling after total knee replacement surgery. The study involves 30 older adults with severe knee osteoarthritis who are having both knees replaced at the same time. One knee receives the injection right after surgery, while the other knee serves as an untreated comparison. Researchers measure leg swelling at several points over three months to see if the treated knee has less fluid buildup.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an injection of berahyaluronidase alfa (tergase) given under the skin around the surgical wound
- What this could lead to
- If it works, this could offer a way to reduce painful swelling and speed recovery after knee replacement surgery.
- What could go wrong
- This is a small, early-stage trial with only 30 people, so results may not apply to everyone. The injection is given right after surgery, and there may be unknown side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Other studies related to the condition(s) this trial covers.
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