Knee replacement showdown: which alignment technique works best?

NCT ID NCT06158646

Knowledge-focused Sponsor: Clinique du Sport, Bordeaux Mérignac Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two different methods of placing a total knee prosthesis: mechanical alignment (standard, fixed angles) and kinematic alignment (customized to each patient's anatomy). Researchers want to see which technique leads to better knee movement and function during activities like walking and climbing stairs. About 120 adults who had a knee replacement one year ago will participate, and their results will be compared to find out if a more personalized approach improves outcomes.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient followed as part of a consultation 1 year after TKA placement * Adult patient * Patient affiliated to a social security system * Patient informed of the study and formally included (signing of informed consent) before the first research review Exclusion Criteria: * Patient with a contralateral knee prosthesis * Patient with another condition (acquired pathology) of the lower limbs (e.g. severe osteoarthritis of the contralateral knee or hip/ankle) and/or of the nervous system (e.g. Parkinson's) which may significantly affect the quality of walking * Pregnant patient * Patient deprived of liberty by judicial or administrative decision, * Adult patient subject to a legal protection measure or unable to express consent

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis,knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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Knee replacement showdown: which alignment technique works best?

What the study statuses mean