New weekly shot could shed pounds and ease knee pain

NCT ID NCT07509307

Recruiting now Symptom relief Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or a placebo injection for several weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NNC0487-0111 (a weekly injection for weight loss and osteoarthritis symptoms)
What this could lead to: If it works, this could offer a new weekly injection that helps people with obesity and knee osteoarthritis lose weight and reduce pain.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not provide meaningful pain relief or weight loss, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder osteoarthritis, knee Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OSTEOARTHRITIS, KNEE OVERWEIGHT

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-351, Poland
ALPHA Recherche Clinique
RECRUITING

Lévis, Quebec, G6V 0C9, Canada
ALPHA Recherche Clinique
RECRUITING

Québec, Quebec, G3K 2P8, Canada
Aarhus Universitetshospital - Klinik for Led og bindevævssygdomme
RECRUITING

Aarhus N, 8200, Denmark
Adana Şehir Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon
RECRUITING

Yuregir/Adana, 01060, Turkey (Türkiye)
Advanced Res for Health Improve
RECRUITING

Naples, Florida, 34102, United States
Ankara Bilkent Şehir Hastanesi- Fizik Tedavi ve Rehabilitasyon
RECRUITING

Çankaya/Ankara, 06800, Turkey (Türkiye)
Arcturus Healthcare, PLC.
RECRUITING

Troy, Michigan, 48098-6368, United States
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
RECRUITING

Marousi, 15125, Greece
Athens Medical Center S.A. (Iatriko Psychikou) - Department of Internal Medicine & Metabolic Diseases
RECRUITING

Athens, 11525, Greece
Auxologico San Luca - Endocrinologia e Malattie del Metabolismo
RECRUITING

Milan, Lombardy, 20149, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Reumatologia
NOT_YET_RECRUITING

Verona, Veneto, 37126, Italy
Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi-Fizik Tedavi ve Rehabilitasyon
RECRUITING

Yıldırım/Bursa, 16310, Turkey (Türkiye)
Casa della Salute di Ceccano - Ambulatori Campus Biomedico
RECRUITING

Rome, Lazio, 00128, Italy
CenterMed Kraków Sp. z o.o.
RECRUITING

Krakow, 31-530, Poland
CenterMed Kraków Sp. z o.o.
NOT_YET_RECRUITING

Krakow, 31-530, Poland
Centre Medical Acadie
RECRUITING

Montreal, Quebec, H4N 2W2, Canada
Centre de Recherche du CHUS
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Centro Especialidades Hermanos Sangro
NOT_YET_RECRUITING

Madrid, 28038, Spain
Centrum Medyczne Intercor Sp. z o.o.
RECRUITING

Bydgoszcz, 85-605, Poland
Centrum Medyczne Intercor Sp. z o.o.
NOT_YET_RECRUITING

Bydgoszcz, 85-605, Poland
Chase Medical Research LLC
RECRUITING

Waterbury, Connecticut, 06708, United States
ClinicMed Daniluk, Nowak Spółka Komandytowa
RECRUITING

Bialystok, 15-879, Poland
Clinical Investigation Spec Gurnee
RECRUITING

Gurnee, Illinois, 60031, United States
Clinical Neuroscience Solutions, Inc.
RECRUITING

Jacksonville, Florida, 32256, United States
Clinvest Research
RECRUITING

Springfield, Missouri, 65807, United States
Clínica Nuevas Tecnologías en Diabetes y Endocrinología
RECRUITING

Seville, 41003, Spain
Coastal Digestive Health
RECRUITING

Maroochydore, Queensland, 4558, Australia
Desert Oasis Healthcare
RECRUITING

Palm Springs, California, 92262, United States
Emeritus Research Sydney
RECRUITING

Botany, New South Wales, 2019, Australia
Evangelismos S.A. - Endocrinology department
RECRUITING

Athens, 10676, Greece
Evanston Premier Hlthcr Res
RECRUITING

Skokie, Illinois, 60077, United States
First Valley Medical Group
RECRUITING

Lancaster, California, 93534, United States
Frederiksberg Hospital - Parker Institutet (Artrose)
RECRUITING

Frederiksberg, 2000, Denmark
H. Infanta Luisa_Endocrino y Obesidad
RECRUITING

Seville, 41010, Spain
Health Res of Hampton Roads
RECRUITING

Newport News, Virginia, 23606, United States
Heart of Australia
RECRUITING

Chelmer, Queensland, 4068, Australia
Hospital For Special Surgery
NOT_YET_RECRUITING

New York, New York, 10021, United States
Hospital General de Valencia
RECRUITING

Valencia, 46014, Spain
Hospital Germans Trias i Pujol
RECRUITING

Badalona, 08916, Spain
Hospital HM La Esperanza
RECRUITING

Santiago de Compostela, 15705, Spain
Hospital Infanta Sofía
RECRUITING

San Sebastián de Los Reyes (Madrid), 28702, Spain
Hospital Naval Ferrol
RECRUITING

Ferrol, 15405, Spain
Hospital Quirónsalud Málaga
RECRUITING

Málaga, 29004, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Instituto Medico Quirurgico San Rafael
RECRUITING

A Coruña, 15006, Spain
Istanbul Üniversitesi- Istanbul Tıp Fakültesi Esnaf Hastanesi Poliklinikleri Fiziksel Tıp Ve Rehabilitasyon Anabilim Dalı
RECRUITING

Fatih/İstanbul, 34116, Turkey (Türkiye)
Kolling Institute
RECRUITING

St Leonards, New South Wales, 2065, Australia
Laiko General Hospital Of Athens - 1st department of Internal Medicine
RECRUITING

Athens, 115 27, Greece
Latin Clinical Trial Center Puerto Rico
RECRUITING

San Juan, 00909, Puerto Rico
MC Dr. Atanasov EOOD
RECRUITING

Sofia, 1231, Bulgaria
MC Excelsior OOD
RECRUITING

Sofia, 1407, Bulgaria
MMA MHAT - Sofia, Rheumatology clinic
RECRUITING

Sofia, 1606, Bulgaria
Mercy Family Clinic
RECRUITING

Dallas, Texas, 75208, United States
Momentum Clinical Research Darlinghurst
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Monroe Biomedical Research, LLC
RECRUITING

Louisville, Kentucky, 40213, United States
NYU Langone Orthopedic Center
NOT_YET_RECRUITING

New York, New York, 10016, United States
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher
RECRUITING

Warsaw, 02-637, Poland
Neighborhood Healthcare
RECRUITING

Escondido, California, 92025, United States
NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes
RECRUITING

Thessaloniki, 54635, Greece
Northwest Clinical Research Center
RECRUITING

Bellevue, Washington, 98007, United States
Northwest Research Center
RECRUITING

Portland, Oregon, 97202, United States
Ospedale Galeazzi S.p.A. - INCO - Istituto Nazionale per la Cura dell'Obesità
RECRUITING

Milan, Lombardy, 20157, Italy
Ospedale S. Maria della Misericordia - Reparto Endocrinologia e Malattie del Metabolismo
RECRUITING

Udine, Friuli Venezia Giulia, 33100, Italy
Piedmont Healthcare/Research
RECRUITING

Statesville, North Carolina, 28625, United States
Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia
RECRUITING

Rome, Lazio, 00128, Italy
Policlinico San Donato di Milano S.p.A - UOS Endocrinologia e del Servizio di Nutrizione Clinica e Prevenzione Cardiometabolica
RECRUITING

San Donato Milanese, Lombardy, 20097, Italy
SBÜ Ankara Gaziler Fizik Tedavi Ve Rehabilitasyon Eğitim Ve Araştırma Hastanesi
RECRUITING

Çankaya/Ankara, 06800, Turkey (Türkiye)
Sanos Clinic - Herlev
RECRUITING

Herlev, 2730, Denmark
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
RECRUITING

Krakow, 31-826, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
NOT_YET_RECRUITING

Krakow, 31-826, Poland
TLC Diabetes and Endocrinology
NOT_YET_RECRUITING

Surrey, British Columbia, V3T 2V6, Canada
Thermi Clinic S.A. - Diabetes and Internal Medicine Department
RECRUITING

Thessaloniki, 57001, Greece
Trakya Üniversitesi Tıp Fakültesi Hastanesi-Fizik Tedavi ve Rehabilitasyon
RECRUITING

Edirne, 22030, Turkey (Türkiye)
UMHAT Sveti Georgi EAD, Plovdiv
RECRUITING

Plovdiv, 4002, Bulgaria
UMHAT Sveti Ivan Rilski EAD, Rheumatology
RECRUITING

Sofia, 1612, Bulgaria
UMHAT Tsaritsa Yoanna - ISUL EAD, Orthopaedics and Traumatology
RECRUITING

Sofia, 1527, Bulgaria
University General Hospital Attikon General Hospital Of West Attica H Agia Varvara - 2nd dept of Internal medicine
RECRUITING

Chaïdári, Attica, 12461, Greece
Westside Center For Clinical Research
RECRUITING

Jacksonville, Florida, 32205, United States
Your Research Network
RECRUITING

Niagara Falls, Ontario, L2H 1H5, Canada
İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi
RECRUITING

Bahçelievler/İstanbul, 34186, Turkey (Türkiye)

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