Can CBD drops replace painkillers for knee arthritis?

NCT ID NCT06414473

Recruiting now Symptom relief Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether taking cannabidiol (CBD) extract under the tongue three times a day can safely ease knee osteoarthritis pain and reduce the need for NSAID painkillers. Thirty adults with moderate to severe knee pain will receive either CBD or a placebo for several weeks. Researchers will track pain levels, physical activity, and side effects to see if CBD is a viable alternative.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cannabidiol (CBD) extract
What this could lead to: If it works, this could point toward a safer, natural option for managing knee osteoarthritis pain without the risks of long-term NSAID use.
What could go wrong: This is a small, early-phase trial (30 people) testing safety and basic effectiveness. CBD may not reduce pain better than placebo, and results may not apply to everyone with osteoarthritis.

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Conditions

The condition(s) this trial relates to.

Motor Activity osteoarthritis osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Sports Medicine Research Laboratory
RECRUITING

Gainesville, Florida, 32601, United States

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