Knee replacement showdown: surgery vs. intensive medical care

NCT ID NCT06643845

Recruiting now Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifestyle changes. The goal is to see if the medical approach can control pain and function as well as surgery, potentially allowing many to avoid or delay the operation. The trial will enroll 1000 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Multimodal medical and non-medical treatments (medications, injections, physical therapy, lifestyle changes)

What this could lead to

If successful, this could offer a way for many people with knee osteoarthritis to avoid or delay major surgery through a comprehensive medical care plan.

What could go wrong

This is an early-stage study with no phase, and the medical approach may not work as well as surgery for some patients. There is also a risk that delaying surgery could lead to worsening symptoms.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AP-HP Cochin
NOT_YET_RECRUITING

Paris, France

Contact Email: •••••@•••••
AP-HP La pitié
NOT_YET_RECRUITING

Paris, France

Contact Email: •••••@•••••
AP-HP Lariboisière
NOT_YET_RECRUITING

Paris, France

Contact Email: •••••@•••••
AP-HP Saint-Antoine
NOT_YET_RECRUITING

Paris, France

Contact Email: •••••@•••••
CH Morlaix
NOT_YET_RECRUITING

Morlaix, France

Contact Email: •••••@•••••
CHD Vendée
NOT_YET_RECRUITING

La Roche-sur-Yon, France

Contact Email: •••••@•••••
CHIC Quimper
RECRUITING

Quimper, France

Contact Email: •••••@•••••
CHU Amiens
NOT_YET_RECRUITING

Amiens, France

Contact Email: •••••@•••••
CHU Brest
RECRUITING

Brest, France

Contact Email: •••••@•••••
CHU Caen
NOT_YET_RECRUITING

Caen, France

Contact Email: •••••@•••••
CHU Le Mans
NOT_YET_RECRUITING

Le Mans, France

Contact Email: •••••@•••••
CHU Limoges
NOT_YET_RECRUITING

Limoges, France

Contact
CHU Montpellier
NOT_YET_RECRUITING

Montpellier, France

Contact Email: •••••@•••••

Contact Email: •••••@•••••
CHU Nantes
NOT_YET_RECRUITING

Nantes, France

Contact Email: •••••@•••••
CHU Nice
NOT_YET_RECRUITING

Nice, France

Contact Email: •••••@•••••
CHU Reims
NOT_YET_RECRUITING

Reims, France

Contact Email: •••••@•••••
CHU Saint Etienne
NOT_YET_RECRUITING

Saint-Etienne, France

Contact Email: •••••@•••••
CHU Strasbourg
NOT_YET_RECRUITING

Strasbourg, France

Contact Email: •••••@•••••
CHU Tours
NOT_YET_RECRUITING

Tours, France

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GHICL- Hôpital Saint Philibert
NOT_YET_RECRUITING

Lomme, France

Contact Email: •••••@•••••
HCL
NOT_YET_RECRUITING

Lyon, France

Contact Email: •••••@•••••