Knee replacement showdown: surgery vs. intensive medical care

NCT ID NCT06643845

Recruiting now Disease control Sponsor: University Hospital, Brest Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches for people with knee osteoarthritis who are already scheduled for knee replacement surgery. One group will have the surgery as planned, while the other will receive a comprehensive medical care plan including medications, injections, and lifestyle changes. The goal is to see if the medical approach can control pain and function as well as surgery, potentially allowing many to avoid or delay the operation. The trial will enroll 1000 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Multimodal medical and non-medical treatments (medications, injections, physical therapy, lifestyle changes)
What this could lead to: If successful, this could offer a way for many people with knee osteoarthritis to avoid or delay major surgery through a comprehensive medical care plan.
What could go wrong: This is an early-stage study with no phase, and the medical approach may not work as well as surgery for some patients. There is also a risk that delaying surgery could lead to worsening symptoms.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

AP-HP Cochin
NOT_YET_RECRUITING

Paris, France
AP-HP La pitié
NOT_YET_RECRUITING

Paris, France
AP-HP Lariboisière
NOT_YET_RECRUITING

Paris, France
AP-HP Saint-Antoine
NOT_YET_RECRUITING

Paris, France
CH Morlaix
NOT_YET_RECRUITING

Morlaix, France
CHD Vendée
NOT_YET_RECRUITING

La Roche-sur-Yon, France
CHIC Quimper
RECRUITING

Quimper, France
CHU Amiens
NOT_YET_RECRUITING

Amiens, France
CHU Brest
RECRUITING

Brest, France
CHU Caen
NOT_YET_RECRUITING

Caen, France
CHU Le Mans
NOT_YET_RECRUITING

Le Mans, France
CHU Limoges
NOT_YET_RECRUITING

Limoges, France
CHU Montpellier
NOT_YET_RECRUITING

Montpellier, France
CHU Nantes
NOT_YET_RECRUITING

Nantes, France
CHU Nice
NOT_YET_RECRUITING

Nice, France
CHU Reims
NOT_YET_RECRUITING

Reims, France
CHU Saint Etienne
NOT_YET_RECRUITING

Saint-Etienne, France
CHU Strasbourg
NOT_YET_RECRUITING

Strasbourg, France
CHU Tours
NOT_YET_RECRUITING

Tours, France
GHICL- Hôpital Saint Philibert
NOT_YET_RECRUITING

Lomme, France
HCL
NOT_YET_RECRUITING

Lyon, France

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