OSTEOARTHRITIS, KNEE

This study looks at 605 people getting knee replacements to compare two types of plastic used in the artificial joint: one with vitamin E and one without. The goal is to see which plastic wears down less and helps patients move better over many years. Participants must be between…

This study looks at two types of knee implants for people with severe knee arthritis. One type uses cement to hold the implant in place, the other does not. The goal is to see which one stays fixed better over 5 years. About 70 people will take part.

This study compares two types of knee surgery for people with arthritis only behind the kneecap. One surgery replaces just the kneecap joint, the other replaces the whole knee. Researchers will track 100 patients for up to 10 years to see which surgery leads to better quality of …

This study compares two types of knee implants (NexGen CR and Persona CR) in 160 adults under 80 with osteoarthritis. The goal is to see which implant helps patients feel more like they have a natural knee, using special X-rays and activity monitors. Results will help surgeons ch…

This study looks at whether taking a short course of oral methylprednisolone (a steroid) after knee replacement surgery can help reduce pain, the need for strong painkillers, and nausea. About 116 adults with knee osteoarthritis who are having a first-time knee replacement will t…

This study looks at whether adding a special therapy for insomnia (CBT-I) to standard knee osteoarthritis care can improve pain, movement, and quality of life more than standard care alone. About 128 adults aged 45+ with both knee osteoarthritis and insomnia will take part. The g…

This study tests a disposable device called the Zero Degree Knee positioner to see if it helps people regain full knee extension faster after total knee replacement. About 154 adults aged 40-80 with knee osteoarthritis will be randomly assigned to use the device or follow standar…

This study looks at whether adding a dietary supplement to an exercise program helps people with knee osteoarthritis feel less pain and move better. About 93 adults with mild to moderate knee osteoarthritis will be split into three groups: supplement alone, supplement plus exerci…

This study looks at whether blocking certain arteries in the knee with tiny particles (embolization) can reduce pain and the need for painkillers in people with knee osteoarthritis. Twelve adults with mild to moderate knee arthritis will get the procedure and be followed for a ye…

This study looks at how well a new knee replacement system (JOURNEY™ II CR) works for people with severe knee arthritis. About 170 adults aged 22 to 75 who need a knee replacement will get the new implant. Researchers will check if it improves knee movement and holds up well over…

This study looks at whether adding a gentle electrical current (interferential current) to a standard exercise program can reduce pain and improve daily function in people with knee osteoarthritis. About 138 adults aged 40-75 with knee pain will be split into three groups: exerci…

This study tests a procedure called genicular radiofrequency ablation (GRFA) for people who still have knee pain more than a year after total knee replacement. The treatment uses heat to calm the nerves around the knee. 44 participants will be randomly assigned to get either the …

This study tests an experimental drug called Allocetra, given as a shot directly into the knee joint, to see if it safely reduces pain in people with knee osteoarthritis. About 160 adults aged 45 to 80 with moderate knee arthritis and ongoing pain despite standard treatments will…

This study aimed to see if a 4-week running gait retraining program could reduce knee pain and improve function in runners with mild to moderate knee osteoarthritis. It planned to enroll adults who run at least 10 km per week and have knee pain. However, the study was withdrawn b…

This pilot study tests whether nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce pain in people with knee osteoarthritis. About 20 adults over age 40 with moderate to severe knee pain will try different NSAID treatments in a crossover design. The goal is to see which drug …

This early-stage study tested a new treatment called ANT-301 in 6 people with severe knee osteoarthritis (grades III/IV). The main goal was to check safety and see if it helps reduce pain and improve knee function. Researchers measured pain using a standard scale and knee functio…

This study tests whether a steroid injection (triamcinolone) given right after knee surgery can reduce pain and inflammation in people with osteoarthritis. 150 adults aged 40 and older who are having arthroscopic knee surgery will receive either the injection or a placebo. The go…

This study looks at 600 people having hip or knee replacement surgery to compare three ways of closing the surgical wound: a special adhesive dressing, skin glue, or suture strips. The goal is to see which method causes the fewest allergic skin reactions and gives the best-lookin…

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who had surgery in the past 3 months will try o…

This study looks at whether watching the steps to prepare a platelet-rich plasma (PRP) injection for knee osteoarthritis can improve how well the treatment works. About 158 adults aged 50-80 with knee osteoarthritis will receive the injection, with some observing the preparation …

This study tests a behavioral program called Moving Well for people waiting for knee replacement surgery. The goal is to see if it helps reduce anxiety and depression before the operation. About 79 adults aged 50 and older who speak English and have internet access are taking par…

This study looked at 62 people having knee replacement surgery to see if a J-shaped cut (instead of the usual straight cut) reduces numbness and pain around the scar. The J-shaped cut curves at the bottom to avoid a nerve that often gets hurt. Researchers measured numbness and pa…

This study looks at whether giving the steroid hydrocortisone through a vein can improve how much people can bend and straighten their new knee after total knee replacement surgery. About 132 adults with knee arthritis who are having their first knee replacement will take part. S…

This study is testing whether adding a pain science education program to standard therapeutic exercises helps people with knee osteoarthritis more than exercises alone. Researchers are comparing two groups of 88 participants to see which approach better improves pain, function, a…

This study uses advanced MRI scans to examine knee cartilage health in 219 people who had ACL reconstruction surgery 10 years ago. Researchers want to understand how post-traumatic osteoarthritis develops after such injuries. Participants are from a larger ongoing study and will …

This study follows 16 people who previously received the experimental drug ICM-203 or a placebo for knee osteoarthritis. Researchers will monitor for any delayed side effects and measure changes in knee pain and function over time. The goal is to understand the long-term safety a…