OSTEOARTHRITIS, KNEE

This study is testing the safety and performance of a specific knee replacement system called JOURNEY II CR. It involves 170 people with severe knee arthritis who need a total knee replacement. Researchers will follow participants for up to 10 years after surgery to see how well …

This study aims to compare a newer knee replacement implant (Persona) with a well-established older model (NexGen) in patients with severe knee arthritis. Researchers will track 185 patients for up to 10 years to see which implant provides better stability, function, and satisfac…

This study is following people for five years after they received an experimental treatment or a placebo for knee osteoarthritis. The main goal is to check for any long-term safety issues and see if the treatment's effects on pain and knee function last over time. It is only for …

This study is testing whether injections of Allocetra, a cell-based therapy, can help control knee osteoarthritis by reducing pain and improving joint function. The trial involves 160 adults with moderate to severe knee arthritis who haven't gotten enough relief from standard tre…

This study compares two surgeries for arthritis that only affects the area under the kneecap. One surgery replaces just the kneecap joint, while the other replaces the entire knee. Researchers are measuring which one helps patients move better, feel less pain, and lasts longer ov…

This early-stage study is testing the safety and initial effectiveness of an experimental injection called ANT-301 for people with moderate to severe knee osteoarthritis. Six participants with significant knee pain will receive the injection to see if it's safe and if it helps re…

This study aims to find out which type of partial knee replacement implant stays fixed in the bone better over time: one that uses surgical cement or one that doesn't. It will follow 70 patients with severe arthritis in just one part of their knee for up to 5 years after surgery.…

This study is comparing two types of plastic liners used in knee replacement implants. One is a standard plastic, and the other has Vitamin E added, which may help it resist wear and last longer. Researchers will follow about 600 patients for many years to see which liner leads t…

This study is testing if a single steroid injection given during a common knee surgery can reduce joint inflammation and slow the progression of arthritis. It will involve 150 patients aged 40 and older who are having surgery for a torn meniscus. Researchers will measure pain lev…

This study is testing whether adding a specific talk therapy for insomnia (CBT-I) to standard knee arthritis care improves outcomes more than standard care alone. It involves 128 adults aged 45+ who have both knee osteoarthritis and chronic insomnia. The main goal is to see if th…

This small pilot study aims to see if the pain medication naproxen helps people with painful knee osteoarthritis feel better. Twenty participants will try both naproxen and a placebo pill in a random order over several weeks, with breaks in between. Researchers will track daily p…

This study aimed to see if teaching runners with knee osteoarthritis a different running style could reduce their pain and lower stress on their knee joints. It planned to enroll runners with mild-to-moderate arthritis for a 4-week training program to modify their gait. The goal …

This study is testing a minimally invasive procedure called genicular radiofrequency ablation (GRFA) for people who still have significant knee pain more than a year after a total knee replacement. It compares the real procedure to a sham (fake) one to see if it safely reduces pa…

This study is testing whether a dietary supplement, exercise, or a combination of both is most effective for managing knee osteoarthritis. It involves 93 adults with knee pain who will take either a real supplement, a placebo, and/or do supervised exercises for 12 weeks. Research…

This study is testing if giving an intravenous steroid (hydrocortisone) right after a total knee replacement helps patients bend and straighten their knee better later on. It involves 132 patients who will be randomly assigned to receive either the steroid or a placebo (saltwater…

This study tests whether a coaching program called 'Moving Well' can help reduce anxiety and depression in people preparing for knee replacement surgery. The program pairs patients with trained coaches who have already had the same surgery. Researchers want to see if this mental …

This study tests whether adding virtual reality therapy or guided relaxation sessions to standard rehab helps older adults recover better after hip or knee replacement surgery. Researchers are comparing these two approaches in 90 patients to see which one more effectively reduces…

This study is testing a special pillow called the Zero Degree Knee positioner to see if it helps people recover better after knee replacement surgery. The device is designed to gently help the knee straighten and may improve movement and reduce pain during home-based recovery. Re…

This study is testing whether a daily gel called AMZ001 can safely reduce pain and other symptoms of knee osteoarthritis. About 540 adults with moderate knee arthritis will apply the gel or a placebo to one knee for six weeks. Researchers will measure changes in pain levels to se…

This study investigates whether seeing the preparation steps for a platelet-rich plasma (PRP) knee injection influences how well patients think it works for osteoarthritis pain. Researchers are testing if patients who watch the injection being prepared report better pain relief a…

This study aims to understand why some people develop knee arthritis years after ACL reconstruction surgery. Researchers will perform detailed MRI scans on 219 people approximately 10 years after their surgery to examine their knee cartilage. The goal is to gather knowledge that …