Can naproxen ease knee arthritis pain? small study aims to find out

NCT ID NCT05430230

Ongoing Symptom relief Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether the anti-inflammatory drug naproxen can reduce pain in people with knee osteoarthritis. Twenty participants will take naproxen or a placebo in a crossover design, meaning each person tries both treatments at different times. The study measures daily pain levels over one week for each treatment period.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Naproxen (an NSAID pain reliever)
What this could lead to: If successful, this study could show that naproxen is effective for managing knee osteoarthritis pain in some people.
What could go wrong: This is a small pilot study with only 20 participants, so results may not apply to everyone. NSAIDs can cause side effects like stomach upset or kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

Northwestern University Feinberg School of Medicine

Chicago, Illinois, 60611, United States

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Other studies related to the condition(s) this trial covers.