Can your own fat cells rebuild a damaged knee?

NCT ID NCT04368806

Ongoing Disease control Sponsor: Nature Cell Co. Ltd. Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial is testing whether a single injection of stem cells taken from a patient's own belly fat can ease the pain and improve the function of knees damaged by osteoarthritis. Half of the participants will receive the stem cell treatment, while the other half will get a placebo (salt water with a bit of their own blood). The study will follow participants for 48 weeks to see if the stem cells help more than the placebo in reducing pain and improving daily activities.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JointStem, a stem cell therapy made from a patient's own fat tissue
What this could lead to: If successful, this could offer a new way to reduce knee pain and improve mobility in people with osteoarthritis, potentially delaying or avoiding joint replacement surgery.
What could go wrong: This is an early-stage trial, so the treatment may not work better than a placebo. There are also risks of side effects from the procedure to harvest and inject the cells.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS, KNEE

Contacts and locations

Locations

BioSolutions Clinical Research Center

La Mesa, California, 91942, United States
Keimyung University Dongsan Hospital

Daegu, Korea, Republic of, 42601, South Korea
Kyung Hee University Hospital At Gangdong

Seoul, Korea, Republic of, 05278, South Korea
Kyung Hee University Medical Center

Seoul, Korea, Republic of, 02447, South Korea
Neurovations Research

Napa, California, 94558, United States
Newport Therapeutics

Newport Beach, California, 92660, United States
Smg-Snu Boramae Medical Center

Seoul, Korea, Republic of, 07061, South Korea
Source Healthcare

Santa Monica, California, 90403, United States
TriWest Research Associates

El Cajon, California, 92020, United States

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