New knee implant study aims to help arthritis sufferers walk Pain-Free

NCT ID NCT05787821

Ongoing Disease control Sponsor: Zimmer Biomet Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study is testing the Persona knee implant in 760 people who need total knee replacement due to arthritis or other knee conditions. The goal is to see if the implant is safe and improves knee function and quality of life. Participants will be followed for several years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Persona knee implant (a device for total knee replacement)
What this could lead to: If successful, this could confirm that the Persona knee implant is safe and improves knee function and quality of life for people needing knee replacement.
What could go wrong: This is an observational study, not a randomized trial, so results may not prove the implant is better than others. Risks include typical surgery complications like infection, implant loosening, or ongoing pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease avascular necrosis osteoarthritis osteoarthritis susceptibility 6 osteoarthritis, knee osteonecrosis polyarticular arthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AVASCULAR NECROSIS FLEXION DEFORMITY OF KNEE KNEE PAIN CHRONIC OSTEOARTHRITIS, KNEE POLYARTHRITIS RHEUMATOID ARTHRITIS TRAUMATIC ARTHRITIS VALGUS DEFORMITY VARUS DEFORMITY

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States
Denver Hip & Knee, Inc.

Parker, Colorado, 80138, United States
Duke University

Morrisville, North Carolina, 27560, United States
Foundation for Orthopaedic Research & Education

Tampa, Florida, 33607, United States
Mayo Clinic

Rochester, Minnesota, 55902, United States
Mississippi Sports Medicine and Orthopaedic Center

Jackson, Mississippi, 39202, United States
NYU

New York, New York, 11016, United States
New Mexico Orthopaedic Associates

Albuquerque, New Mexico, 87110, United States
Northside Hospital, Inc.

Atlanta, Georgia, 30342, United States
OrthoCarolina Research Institute, Inc.

Charlotte, North Carolina, 28207, United States
St. Francis Hospital & Heart Center

Roslyn, New York, 11576, United States
Syracuse Orthopaedic Specialists

DeWitt, New York, 13214, United States
U of L Health

Louisville, Kentucky, 40202, United States
UT Health at Houston

Houston, Texas, 77030, United States
UVA Health Orthopedic Center

Charlottesville, Virginia, 22903, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States

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