RHEUMATOID ARTHRITIS

This study explores whether fecal transplants (capsules containing healthy donor stool) can improve quality of life and control inflammation in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. T…

This study tests a new drug called AZD1163 in 320 adults with moderate-to-severe rheumatoid arthritis who haven't responded well to standard treatments. The goal is to see if the drug reduces joint swelling and pain over 12 weeks. Participants will receive either AZD1163 or a pla…

This study tests whether combining two drugs, telitacicept and baricitinib, can help people with rheumatoid arthritis that hasn't improved with other treatments. About 30 adults aged 18 to 85 will take the combination and be monitored for joint swelling and pain. The goal is to s…

This early-phase study tests a new treatment called CC-97540, which uses a person's own immune cells (CAR T cells) to target and calm the overactive immune system in severe autoimmune diseases like lupus, myositis, scleroderma, and rheumatoid arthritis. The goal is to see if it i…

This study is testing a new knee implant (Persona) in 760 people who need knee replacement surgery due to arthritis or other knee problems. The goal is to see if the implant is safe, works well, and helps patients move better and feel less pain. Participants will be followed for …

This study looks at whether adding a family doctor to a rheumatology team can help people with rheumatoid arthritis get better care for other health problems like infections, heart disease, and weak bones. About 199 adults with rheumatoid arthritis will have their regular rheumat…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study checks if a surgical robot (ROSA Knee) can help surgeons make last-minute adjustments during total knee replacement. About 80 people with knee arthritis or rheumatoid arthritis will take part. The goal is to see if the robot's ability to change the bone cut plan during…

This study tests whether regularly measuring drug levels in the blood (therapeutic drug monitoring) can help adults with rheumatoid arthritis maintain disease control and avoid flares. 350 participants on a standard arthritis medication will be followed for 18 months. Half will h…

This early-stage trial tests a new treatment called AZD0120 for people with certain autoimmune diseases like systemic sclerosis, myositis, or hard-to-treat rheumatoid arthritis. AZD0120 uses a patient's own immune cells, which are modified in a lab to target and attack faulty imm…

This early-stage study tests whether a new drug called AZD5492 is safe and tolerable in adults with lupus, myositis, or rheumatoid arthritis. About 72 participants will receive either one or two doses of the drug and be monitored for side effects over 6 months. The goal is to gat…

This early-stage study tests a new drug called surovatamig in 48 adults with rheumatoid arthritis or lupus. The main goal is to check safety and how the body handles the drug. Participants receive increasing doses to find the best and safest amount.

This study tests a new medicine called SPY002-072 in adults with moderate-to-severe rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. About 285 participants will receive either the drug or a placebo to see if it reduces joint swelling and pain. The goal is to…

This study is testing whether an anti-inflammatory diet can improve disease activity in people with rheumatoid arthritis. Researchers will enroll 124 adults with low to moderate disease activity who are not changing their current treatments. The goal is to see if the diet reduces…

This study is testing a silicone joint implant called KeriFlex® for people with arthritis in the hand (rheumatoid, degenerative, or traumatic). The goal is to see if the implant improves hand function and is safe over time. About 86 adults who need joint replacement in their fing…

This study compares two treatments for adults with active rheumatoid arthritis who have a specific joint tissue type (myeloid-stromal) that often leads to poor outcomes. Participants will either receive standard methotrexate alone or methotrexate combined with tofacitinib for 12 …

This early-phase study is testing a new drug called LFD-200 to see if it is safe and how the body processes it. The trial includes healthy adults and people with moderate to severe rheumatoid arthritis. Participants receive either the drug, a placebo, or an active comparator. The…

This early-stage study tests a new drug called CPTX2309 in healthy people and those with moderate to severe rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). The main goal is to check if the drug is safe and tolerable. About 64 adults will take part, receiving the …

This early-stage study tests a new drug called SBT777101 in 24 adults with moderate-to-severe rheumatoid arthritis who haven't responded well to other treatments. The main goal is to check safety and side effects when given as a single dose. Researchers will start with low doses …

This study tests an experimental drug called Afimkibart (RO7790121) in 160 adults with moderate to severe rheumatoid arthritis who did not get better with or could not tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo …

This study tests whether CIT-013 can reduce disease activity in adults with moderately active rheumatoid arthritis. About 88 participants will receive either CIT-013 or a placebo every other week for 6 weeks. Researchers will monitor symptoms and side effects to see if the drug i…

This early-stage study is testing a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like lupus, scleroderma, and rheumatoid arthritis that haven't responded to standard therapies. The treatment uses specially engineered immune …

This study tests a new treatment using specially engineered immune cells (CAR-T cells) to target and destroy faulty B cells in people with severe autoimmune diseases like lupus, rheumatoid arthritis, and scleroderma. About 72 adults aged 18-70 will receive a single infusion of th…

This study tests a new treatment plan for people with rheumatoid arthritis (RA) who still have active disease despite standard medications. The plan starts with a fast-acting drug (TNF inhibitor) for 12 weeks, then switches to a longer-acting drug (abatacept) to try to achieve re…

This study tests whether adding roflumilast (a lung drug) or desloratadine (an allergy drug) to standard rheumatoid arthritis treatment can better control the disease. About 90 adults with active arthritis will take one of these medicines or a placebo for 12 weeks. Researchers wi…

This study tests whether a collaborative approach between pharmacists and doctors can help people with rheumatoid arthritis take their disease-modifying medications more consistently. Researchers will compare patients who receive this team-based care to those who get usual follow…

This early-stage study tests a new medicine called SR-878 in 27 adults with rheumatoid arthritis. The goal is to find a safe dose by checking for side effects. Participants will take the drug once and be monitored for about 16 weeks. This is not a cure; it aims to control the dis…

This study tests whether pentoxifylline, a drug already used for other conditions, can reduce inflammation in people with rheumatoid arthritis (RA). Researchers will give it to 50 adults with active RA who are already on standard medications. The main goal is to see if it improve…

This early-stage study tests a new drug called PIT565 in people with rheumatoid arthritis (RA). The main goal is to check if the drug is safe and how the body processes it. About 57 adults with RA will take part. The study is open-label, meaning everyone knows they are getting th…

This early-stage study tests a new medicine called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and how well the body handles it. Participants will be followed for up to a year, and the study also loo…

This study tests whether baricitinib, a JAK inhibitor, can help repair bone damage (erosion) in people with active rheumatoid arthritis. Sixty adults with active RA and at least one bone erosion will receive either baricitinib or a placebo for 24 weeks. The main goal is to see if…

This early-stage study tests a new treatment called HN2301 in 30 people with lupus, scleroderma, or rheumatoid arthritis. The main goal is to check safety and find the right dose. Researchers will also see if the therapy can reduce disease activity by targeting immune cells.

This study tests three new treatments for adults with moderate to severe rheumatoid arthritis (RA) who have not improved with at least one prior therapy. Participants will receive either a single drug (lutikizumab or ravagalimab), a combination of both, or a placebo. The goal is …

This study looks at the risk of major heart problems in people with rheumatoid arthritis (RA) who are taking either a combination of tofacitinib and a statin, or a TNF inhibitor. The goal is to see which treatment is safer for the heart. The study involves 120 adults aged 50 and …

This study is testing whether taking vitamin E supplements for one month can help reduce inflammation and ease symptoms in people with rheumatoid arthritis. Researchers will compare vitamin E against a placebo (inactive pill) in 46 female participants who have early-stage rheumat…

This study looks at whether a quick, radiation-free lung ultrasound can detect interstitial lung disease (ILD) in people with rheumatoid arthritis. ILD is a serious complication that can be deadly, but current detection relies on expensive CT scans. Researchers will compare ultra…

This early-stage study tests a new drug called plamotamab in 68 adults with moderate to severe rheumatoid arthritis who have not responded well to other treatments. The main goal is to check the drug's safety and side effects when given as an injection under the skin. Researchers…

This early-stage study tests the safety and how the body handles a new drug called GS-0151 in 75 adults with rheumatoid arthritis. Participants receive multiple doses of the drug or a placebo. The goal is to find out if the drug is safe and well-tolerated, not yet to prove it wor…

This pilot study tests whether a supervised, at-home exercise program combining aerobic and resistance training is feasible for people recently diagnosed with rheumatoid arthritis (within 6 months). Fifteen participants will follow the program remotely, and researchers will measu…

This early-stage study tests a new medicine called MK-1045 in 21 people with lupus or rheumatoid arthritis. The main goal is to check if the drug is safe and tolerable at different doses. This is not a cure; it aims to understand how the drug works in the body and its side effect…

This study tests whether an online program that teaches better diet and self-care can reduce fatigue and improve quality of life for adults with rheumatoid arthritis, Sjogren's syndrome, lupus, mixed connective tissue disease, or psoriatic arthritis. About 200 participants will u…

This study is creating a registry of 1,000 pregnant women with autoimmune diseases like lupus and rheumatoid arthritis. Researchers will track their health and pregnancy outcomes to identify risk factors and ways to improve care for both mothers and babies. The study does not tes…

This study looks at how accurately surgeons can place a new hip socket (cup) using a special computer navigation system that doesn't require extra cuts or pins. About 118 people getting a standard hip replacement will have their surgery guided by this system, and X-rays at 6 week…

This study is building a large database and sample bank from 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will use this information to find links between patient outcomes and biological markers. The goal is to…

This study looks at 750 adults with rheumatoid arthritis (RA) who are at risk for developing interstitial lung disease (ILD). Researchers use chest CT scans and track changes over 3-5 years to find early signs and risk factors. The goal is to better understand who might develop l…

This study looks at why migraine is more common in people with autoimmune diseases like multiple sclerosis or rheumatoid arthritis. Researchers will measure immune cells and inflammatory markers in 396 women with and without migraine, including those with autoimmune conditions. T…

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease) and may receive immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to use and helpful for …

This study aims to collect information on how well shoulder replacements work over the long term, following up to 20,000 people for at least 10 years. Participants have various shoulder problems like arthritis, rotator cuff tears, or fractures. The goal is to better understand th…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biological markers that can predict how well a patient will respond to…

This study is testing a new data platform for people receiving a total knee replacement. It will use sensors and a patient app to collect information and look for unknown risks or side effects. About 600 adults who are getting a B. Braun knee implant and can use the app and senso…

This study looks at how a drug called abatacept (Orencia) affects immune cells in people with rheumatoid arthritis. Researchers will compare patients starting abatacept, those on other treatments, and healthy volunteers. The goal is to understand why joints swell and hurt, and fi…

This study looks at 200 adults with rheumatoid arthritis to understand why some people feel worse when they slowly reduce their steroid medication (like prednisone), while others do fine. Researchers will measure inflammation, brain activity, and hormone levels to find clues. The…

This study will follow 200 adults with rheumatoid arthritis that does not get better with standard treatments. The goal is to learn more about this hard-to-treat form of arthritis and find better ways to manage it. Researchers will track symptoms, quality of life, and look for cl…

This study looks at how people with fibromyalgia or rheumatoid arthritis experience pain differently. Researchers will measure pain thresholds in 150 adults to better understand the underlying pain mechanisms. The goal is to improve knowledge, not to test a new treatment.

This study looks at whether adding breathing muscle training to standard rehab helps people with rheumatoid arthritis who also have lung disease. Researchers will measure changes in exercise ability, breathlessness, and a specific gene (HOTAIR) linked to inflammation. About 39 ad…

This study looks at why people with rheumatoid arthritis often have trouble controlling high blood pressure, which raises their risk of heart disease. Researchers will work with 25 adults to test a program that helps them monitor their blood pressure and share results with their …

This study is trying to figure out which rheumatoid arthritis medication works best for which person. Instead of a one-size-fits-all approach, researchers will use advanced computer analysis and detailed patient data to match each participant with the most effective drug. The goa…