RHEUMATOID ARTHRITIS

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This early-stage study tests a single dose of ABBV-519 in 30 adults with moderate lupus or rheumatoid arthritis. Researchers will check how the drug moves through the body, how it affects immune cells, and whether it is safe. Participants will be followed for about a year to moni…

This study tests a new medicine called SBT777101 in 24 people with moderate-to-severe rheumatoid arthritis (RA). It is the first time this drug is given to humans, so the main goal is to check safety and side effects. Participants receive a single dose, and the dose is increased …

This study tests an experimental drug called Afimkibart (RO7790121) in 160 people with moderate to severe rheumatoid arthritis who did not get better with or could not tolerate standard treatments like TNF or JAK inhibitors. Participants will receive either the drug or a placebo …

This early-stage trial tests a new treatment called AZD0120 for adults with three autoimmune diseases: systemic sclerosis, idiopathic inflammatory myopathies, or difficult-to-treat rheumatoid arthritis. AZD0120 is made from a patient's own immune cells, which are modified in a la…

This study is testing the long-term safety and effectiveness of a drug called afimkibart in people with moderate to severe rheumatoid arthritis. Participants have already taken afimkibart in a previous study and will continue taking it. The goal is to see if the drug remains safe…

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This study tests an experimental drug called AZD1163 in 320 people with moderate-to-severe rheumatoid arthritis who haven't gotten enough relief from standard treatments. Participants receive either AZD1163 or a placebo as an injection, along with their usual care. The main goal …

This early-stage study tests an experimental drug called LY4298445 in healthy volunteers and people with lupus or rheumatoid arthritis. The main goal is to check safety and how the body handles the drug. Participants will receive either the drug or a placebo, and the study lasts …

This phase 2 study tests two experimental drugs, lutikizumab and ravagalimab, alone or together, in about 180 adults with moderate-to-severe rheumatoid arthritis who have not improved with other treatments. The goal is to see if these drugs can reduce joint pain and swelling bett…

This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study tests whether adding roflumilast to standard treatment can reduce joint pain and swelling in people with active rheumatoid arthritis. About 50 adults aged 18-60 will take either roflumilast or a placebo for 12 weeks. Researchers will measure changes in disease activity…

This phase 2 trial is testing whether adding desloratadine, an allergy medication, to standard rheumatoid arthritis therapy can reduce joint inflammation and disease activity. Sixty adults with active RA will receive either desloratadine or a placebo for 12 weeks. The study measu…

This early-stage trial is testing a new drug called GS-0151 in 75 adults with rheumatoid arthritis. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either GS-0151 or a placebo for 12 weeks.

This study follows 50 people who receive a Zimmer Biomet shoulder replacement implant to see if it safely improves pain, movement, and quality of life over two years. Participants have shoulder arthritis, fractures, or other joint damage. The main goal is to measure a meaningful …

This early-phase trial is testing a new drug called BMS-986454 in 46 adults with rheumatoid arthritis who did not fully respond to methotrexate. The main goal is to check the drug's safety, tolerability, and how it moves through the body. Participants will receive either the drug…

This study tests a new treatment called NKX019 for people with autoimmune diseases like systemic sclerosis, rheumatoid arthritis, and vasculitis. NKX019 uses specially engineered immune cells to target and calm overactive B cells that cause the disease. The goal is to see if it i…

This early-stage trial is testing a new treatment called CC-97540, which uses a patient's own immune cells modified to target and destroy faulty immune cells. It is for people with severe forms of lupus, myositis, scleroderma, or rheumatoid arthritis that have not improved with s…

This early-stage trial tests a single injection of JADE201 in 36 adults with rheumatoid arthritis. The main goal is to check safety and how the body processes the drug. Participants receive either JADE201 or a placebo, and researchers monitor side effects and drug levels in the b…

This study tests a new drug called CIT-013 in 88 adults with moderately active rheumatoid arthritis. Participants will receive either CIT-013 or a placebo every two weeks for six weeks. The goal is to see if CIT-013 reduces joint swelling and pain better than a placebo, and to ch…

This study tests a new drug called GenSci120 in 450 adults with moderate-to-severe rheumatoid arthritis who haven't improved with standard treatments. Participants receive either GenSci120, an existing drug (adalimumab), or a placebo for 14 weeks, followed by an extension period.…

This study is checking the long-term safety and effectiveness of an experimental drug called TLL-018 for people with rheumatoid arthritis. It is for adults who have already finished a previous study of this drug. The goal is to see how well the drug controls arthritis symptoms ov…

This study tests whether adding either roflumilast (a COPD drug) or desloratadine (an allergy drug) to standard rheumatoid arthritis treatment can better control the disease. About 90 adults with active RA will take one of these drugs or a placebo for 12 weeks. The goal is to see…

This study tests whether adding tofacitinib to standard methotrexate works better than methotrexate alone for people with active rheumatoid arthritis who have a specific 'myeloid-stromal' type. 130 adults will be randomly assigned to either the combo or methotrexate-only group fo…

This early-stage trial tests a new medicine called SR-878 in 27 adults with rheumatoid arthritis. The drug works by blocking a protein that controls immune signals. The main goal is to check safety and find a good dose. Participants will be followed for about 16 weeks.

This study tests a new treatment called anti-CD19/BCMA universal CAR-T cells for people with severe autoimmune diseases like rheumatoid arthritis, lupus, and scleroderma. The therapy aims to reset the immune system by targeting and removing faulty B cells. About 72 adults will re…

This study looks at whether taking tofacitinib (a rheumatoid arthritis drug) along with a statin (a cholesterol-lowering drug) can lower the chance of serious heart problems in people with rheumatoid arthritis. The study will compare this combination to another standard treatment…

This study is following 584 people who received Zimmer Biomet shoulder implants to see how well the devices work over 10 years. Participants have shoulder arthritis, fractures, or deformities. Researchers will track implant survival, pain, function, and any side effects. The goal…

This early-stage study tests a new therapy, HN2301, in 30 adults with lupus, scleroderma, or rheumatoid arthritis. The main goal is to check safety and find the right dose. Researchers will also look for early signs that the treatment helps control the disease by measuring immune…

This early-stage trial is testing a new biologic drug called plamotamab in 68 adults with moderate to severe rheumatoid arthritis (RA) who haven't gotten enough relief from other treatments. The drug is given as a shot under the skin, and the main goal is to see if it's safe and …

This study tests whether a surgical robot (ROSA Knee) can help surgeons adjust their knee replacement plan during the operation based on the condition of the patient's soft tissues. About 80 adults with knee arthritis or rheumatoid arthritis will take part and be followed for 2 y…

This study is testing whether a combination of two drugs, telitacicept and baricitinib, can help people with difficult-to-treat rheumatoid arthritis. The trial will enroll 30 adults aged 18 to 85 who have not responded to other treatments. Researchers will measure joint swelling …

This early-stage study tests a new drug, CPTX2309, to see if it is safe and tolerable. It involves 64 healthy adults and people with moderate to severe rheumatoid arthritis or lupus. Researchers will monitor side effects, lab results, and immune responses to determine the drug's …

This study compares a robot-assisted system (CORI) to conventional manual instruments for total knee replacement. About 140 participants will be randomly assigned to one of the two methods. The main goal is to see if the robot helps achieve more precise leg alignment after surger…

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a plac…

This early-phase study tests a new type of CAR-T cell therapy (called KN3601) for people with severe autoimmune diseases like lupus, scleroderma, Sjögren's syndrome, rheumatoid arthritis, and vasculitis that haven't responded to standard treatments. The therapy uses specially eng…

This Phase 1 trial tests surovatamig, a bispecific T-cell engager, in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. The study gives the drug as injections in increasing doses to check safety, side effects, and how the body processes it. It is too early to k…

This study is testing the Persona knee implant in 760 people who need total knee replacement due to arthritis or other knee conditions. The goal is to see if the implant is safe and improves knee function and quality of life. Participants will be followed for several years after …

This study is testing a new type of knee implant that doesn't require bone cement, in 130 people needing total knee replacement. The goal is to see if the implant improves knee function, reduces pain, and helps patients feel more natural after surgery. Researchers will track outc…

This study is testing whether an anti-inflammatory diet can help people with rheumatoid arthritis feel better and reduce disease activity. Researchers will compare two different anti-inflammatory diets in 124 adults with low to moderate disease activity. The goal is to see if die…

This study is testing a new hip replacement system called Emphasys Hip Solutions in 30 people with hip osteoarthritis. Researchers will use special X-ray imaging to see how well the implant stays in place over two years. The goal is to make sure the implant is stable and works we…

This study tests whether fecal microbiota transplants (FMT) given as capsules can safely improve symptoms in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hundred participants will receiv…

This study tests whether baricitinib, a JAK inhibitor, can heal bone erosion in people with active rheumatoid arthritis. Sixty adults with moderate-to-severe RA and at least one bone erosion will receive either baricitinib or a placebo for 24 weeks. The main goal is to see if the…

This Phase 3 trial tests a sequential treatment strategy for rheumatoid arthritis (RA). Participants first receive a TNF inhibitor for 12 weeks, then switch to abatacept. The goal is to see if this approach leads to more remissions than staying on TNF inhibitors alone. The study …

This study tests whether extra support from a pharmacist—starting in the hospital and continuing after discharge—can help people with rheumatoid arthritis take their disease-modifying medications more consistently. Two hundred participants will either receive this pharmaceutical …

This study is testing a silicone implant called KeriFlex® to replace damaged finger joints in people with rheumatoid arthritis, osteoarthritis, or post-traumatic arthritis. The goal is to see if the implant improves hand function and is safe over time. About 86 adults will receiv…

This Phase 2 trial tests whether adding pentoxifylline (a drug usually used for blood flow) to standard methotrexate therapy can reduce inflammation in people with active rheumatoid arthritis. Fifty adults aged 18–70 with moderate-to-severe disease will receive the combination fo…

This study tests whether a quick, non-invasive lung ultrasound can detect interstitial lung disease in people with rheumatoid arthritis. About 280 adults with RA and risk factors for lung disease will get an ultrasound, and results will be compared to standard chest CT scans. If …

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This early-stage study tests a new drug called LFD-200 in healthy volunteers and people with moderate to severe rheumatoid arthritis (RA). The main goal is to check safety and how the body processes the drug. Researchers will give single or multiple doses and watch for side effec…

This pilot study is testing whether a remotely-delivered exercise program is practical and acceptable for people recently diagnosed with rheumatoid arthritis (within 6 months). Fifteen participants will receive intensive aerobic and resistance training via video calls. The main g…

This study tests whether taking vitamin E (alpha-tocopherol) supplements for one month can reduce inflammation and disease activity in people with rheumatoid arthritis. Researchers will compare vitamin E to a placebo in 46 women with early RA. Participants take two capsules daily…

This study compares two treatments for shoulder pain caused by arthritis or rotator cuff problems: a steroid injection into the joint versus a nerve block. Forty adults with shoulder arthritis will be randomly assigned to one of the two treatments. Researchers will track pain lev…

This study tests an online wellness course that teaches diet, exercise, stress reduction, and self-care to people with rheumatoid arthritis, lupus, Sjogren's syndrome, and similar conditions. Researchers want to see if the program reduces fatigue and improves quality of life. Abo…

This study looks at whether giving the painkiller nalbuphine at different times during knee replacement surgery can better control pain and keep the heart stable in patients aged 65 and older. About 162 participants will receive nalbuphine either during anesthesia or after cement…

This study tests whether taking krill oil supplements for 12 weeks can improve muscle strength and function in adults with long-term conditions like diabetes, heart disease, or arthritis. Thirty participants will be randomly assigned to receive either krill oil or a placebo. Rese…

This study tests a custom-made thumb brace (thermoplastic orthosis) for people with rheumatoid arthritis who have a boutonniere deformity, a condition where the thumb bends abnormally. About 60 women aged 18-65 will be split into two groups: one gets the custom brace, the other a…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study looks at whether certain genes make some people more likely to develop eye damage from the drug Plaquenil, which is used for autoimmune diseases like lupus and rheumatoid arthritis. Researchers will compare people who have had eye damage from Plaquenil with those who h…

This study is looking for clues to predict how well different rheumatoid arthritis (RA) drugs will work in individual patients. Researchers will give 400 adults with RA one or more standard medications and track their response over 16 weeks. The goal is to find genetic or other f…

This study collects information from 10,000 adults who have had hip or knee replacement surgery at Heidelberg University Hospital. Researchers will follow participants during routine check-ups to see how long the artificial joints last, how well they function, and what problems m…

This study looks at how heavy smartphone use impacts neck posture, muscle strength, balance, and tongue pressure in people with rheumatoid arthritis or ankylosing spondylitis. Researchers will compare these patients to healthy individuals to separate the effects of the disease fr…

This study looks at how well a non-invasive navigation system helps surgeons place the hip cup during total hip replacement. About 118 people with hip conditions like arthritis or hip dysplasia will take part. The goal is to see if the actual cup position matches the planned posi…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study tests a special dye and camera to look at lymph vessels in the hands of people with rheumatoid arthritis. The dye is injected into the skin and glows under a near-infrared camera, allowing researchers to see how lymph fluid moves. The goal is to better understand how t…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study will use nerve conduction tests to check for nerve damage in 60 adults with rheumatoid arthritis. Half are taking baricitinib (Olumiant), a JAK inhibitor, and the other half are on standard disease-modifying drugs. The goal is to see if baricitinib is linked to a highe…

This study follows 200 adults with rheumatoid arthritis who are already in stable remission from standard medications. Researchers will track their health over up to 5 years using exams, ultrasound, and X-rays to see who stays well and who has a flare. The goal is to learn how to…

This study looks at whether a doctor's computer tool (MedSafer) and patient brochures (EMPOWER) can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic diseases who take five or more regular drugs. Researchers will follow 100 particip…

This study looks at 750 people with rheumatoid arthritis (RA) who are 45 or older to find early signs of interstitial lung disease (ILD), a serious lung complication. Researchers will use CT scans and track changes over 3-5 years to identify risk factors. The goal is to better un…

This study looks at how pain is processed in people with fibromyalgia and rheumatoid arthritis, two conditions that cause long-term pain. Researchers will measure pressure pain thresholds in 150 adults to compare pain mechanisms. The goal is to better understand the differences a…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with connective tissue diseases like scleroderma or rheumatoid arthritis. Researchers will analyze tiny particles in the blood called extracellular vesicles and use AI to exami…

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. The goal is to…

This study will follow 200 adults with rheumatoid arthritis (RA) that does not respond well to standard treatments, known as refractory RA. The goal is to learn more about why some people have hard-to-treat RA and find clues to better personalize their care. Participants will be …

This study looks at whether palliative and supportive care, usually given to people near the end of life, could also help those with long-term inflammatory arthritis like rheumatoid arthritis. Researchers will interview patients and survey healthcare professionals to understand u…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This pilot study will enroll 600 people getting total knee replacements to test a data platform called Pheno4U. Participants will use a sensor and a smartphone app to track their recovery. The goal is to identify unknown risks or side effects and improve personalized care. The st…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study will follow 300 people with knee osteoarthritis or chronic inflammatory arthritis for up to 10 years. Researchers will collect blood, joint fluid, and platelet-rich plasma samples to look for biomarkers linked to pain, joint damage, and the need for knee replacement. T…

This study is for people with rheumatoid arthritis who are starting a drug called abatacept (Orencia). Researchers want to see how this drug changes certain immune cells (T and B cells) in the blood over 6 months. They will compare these changes to those in people taking other ar…

This study looks at how genetic differences influence the effectiveness and side effects of leflunomide, a common rheumatoid arthritis drug. Researchers will recruit 110 Pakistani patients starting leflunomide and track their disease activity and side effects over six months. By …

This study looks at why people with rheumatoid arthritis often have trouble controlling high blood pressure, which raises their risk of heart disease. Researchers will work with 25 adults to test a program that helps them monitor their blood pressure and share results with their …

This study is for 75 adults with rheumatoid arthritis whose current treatments have stopped working. The goal is to learn how to match each patient to the most effective drug for them, using advanced computer analysis and health data. This is a research study to gather informatio…

This study collects blood and optional spinal fluid samples from 350 people with Parkinson's, ALS, glioblastoma, certain cancers, or rheumatoid arthritis. The goal is to find new genetic markers that could lead to better diagnostic tests for autoimmune encephalitis and paraneopla…

This registry enrolls pregnant women or those planning pregnancy who have autoimmune diseases like lupus or rheumatoid arthritis. Researchers at Duke University will track health data to find ways to improve outcomes for mothers and babies. The goal is to better understand risk f…

This study looks at whether standard breathing exercises and extra muscle-strengthening breathing training can affect a specific gene (HOTAIR) in people with rheumatoid arthritis who also have lung disease. Researchers will compare two groups: one doing standard rehab and one add…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study is testing two different ways to slowly reduce the dose of the steroid prednisone in people with rheumatoid arthritis. One group will taper over 15 days, the other over 150 days. Researchers want to see who develops symptoms or flare-ups during the taper, and why. The …

This study looks at whether adding a family doctor to a rheumatology team can improve care for other health issues in people with rheumatoid arthritis. About 199 adults with rheumatoid arthritis will have their vaccination, heart, and bone health checked by a special family docto…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …