New RA drug BMS-986454 enters early human testing

NCT ID NCT07171983

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This early-phase trial is testing a new drug called BMS-986454 in 46 adults with rheumatoid arthritis who did not fully respond to methotrexate. The main goal is to check the drug's safety, tolerability, and how it moves through the body. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure drug levels in the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BMS-986454
What this could lead to: If this early trial shows the drug is safe and well-tolerated, it could pave the way for larger studies to see if BMS-986454 helps control rheumatoid arthritis symptoms.
What could go wrong: This is a very early Phase 1b study with only 46 participants, focused on safety and drug levels—not yet on effectiveness. The drug may not work or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

All India Institute of Medical Sciences (AIIMS) - Nagpur
RECRUITING

Nagpur, Maharashtra, 441108, India
Apollo Hospitals Ahmedabad
RECRUITING

Ahmedabad, Gujarat, 382428, India
Kalinga Institute of Medical Sciences- Bhubaneswar
RECRUITING

Bhubaneswar, Odisha, 751024, India
Krishna Institute of Medical Sciences Limited
RECRUITING

Secunderabad, Telangana, 500003, India
Life Point Mutispecialty Hospital Pvt. Ltd.
RECRUITING

Pune, Maharashtra, 411057, India
Local Institution - 0002
NOT_YET_RECRUITING

Hyderabad, Telangana, 500004, India
Local Institution - 0003
NOT_YET_RECRUITING

Bangalore, Karnataka, 560 034, India
Local Institution - 0009
NOT_YET_RECRUITING

Mysuru, Karnataka, 5700004, India
Nizams Institute Of Medical Sciences
RECRUITING

Hyderabad, Andhra Pradesh, 500 082, India

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