New RA drug BMS-986454 enters early human testing
NCT ID NCT07171983
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a new drug called BMS-986454 in 46 adults with rheumatoid arthritis who did not fully respond to methotrexate. The main goal is to check the drug's safety, tolerability, and how it moves through the body. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure drug levels in the blood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BMS-986454
What this could lead to
If this early trial shows the drug is safe and well-tolerated, it could pave the way for larger studies to see if BMS-986454 helps control rheumatoid arthritis symptoms.
What could go wrong
This is a very early Phase 1b study with only 46 participants, focused on safety and drug levels—not yet on effectiveness. The drug may not work or could have side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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All India Institute of Medical Sciences (AIIMS) - Nagpur
RECRUITINGNagpur, Maharashtra, 441108, India
Contact Phone: •••-•••-••••
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Kalinga Institute of Medical Sciences- Bhubaneswar
RECRUITINGBhubaneswar, Odisha, 751024, India
Contact Phone: •••-•••-••••
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Krishna Institute of Medical Sciences Limited
RECRUITINGSecunderabad, Telangana, 500003, India
Contact Phone: •••-•••-••••
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Life Point Mutispecialty Hospital Pvt. Ltd.
RECRUITINGPune, Maharashtra, 411057, India
Contact Phone: •••-•••-••••
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Local Institution - 0002
NOT_YET_RECRUITINGHyderabad, Telangana, 500004, India
Contact
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Local Institution - 0003
NOT_YET_RECRUITINGBangalore, Karnataka, 560 034, India
Contact
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Local Institution - 0004
NOT_YET_RECRUITINGAhmedabad, Gujarat, 382428, India
Contact
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Local Institution - 0009
NOT_YET_RECRUITINGMysuru, Karnataka, 5700004, India
Contact
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Nizams Institute Of Medical Sciences
RECRUITINGHyderabad, Andhra Pradesh, 500 082, India
Contact Phone: •••-•••-••••