New drug aims to tame immune system in lupus and Sjogren's

NCT ID NCT06977724

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This early-stage trial tests an investigational drug called ABBV-319 in 36 adults with lupus or Sjogren's disease. The drug is designed to deplete overactive B cells, which are part of the immune system that cause inflammation and symptoms. Participants receive two doses by IV, 21 days apart, and are monitored for safety, side effects, and how the drug moves through the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ABBV-319
What this could lead to: If it works, this could point toward a new treatment option for lupus and Sjogren's disease by reducing harmful immune cells.
What could go wrong: This is a very early Phase 1 trial with only 36 people, so it's mainly checking safety and dosing. It may not improve symptoms, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dry eye syndrome rheumatoid arthritis Sjogren syndrome systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRY EYE SYNDROME SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

Advanced Quality Medical Research /ID# 278462
RECRUITING

Orland Park, Illinois, 60462, United States
Amsterdam University Medical Center /ID# 274286
RECRUITING

Amsterdam, North Holland, 1105 AZ, Netherlands
CHU de Montpellier - Hopital Lapeyronie /ID# 279892
RECRUITING

Montpellier, Herault, 34090, France
Clinical Research Of West Florida - Phase I Unit /ID# 275834
NOT_YET_RECRUITING

Clearwater, Florida, 33765, United States
Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 275836
RECRUITING

Tampa, Florida, 33606, United States
Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 278239
NOT_YET_RECRUITING

Avon Park, Florida, 33825, United States
Integrative Rheumatology of South Texas - Harlingen /ID# 276458
RECRUITING

Harlingen, Texas, 78550, United States
Les Hopitaux Universitaires de Strasbourg - Hopital de Hautepierre /ID# 272692
RECRUITING

Strasbourg, Alsace, 67200, France
Life Clinical Trials - Colonial Drive - Margate /ID# 276050
RECRUITING

Margate, Florida, 33063, United States
Private Practice - Dr. Ramesh C. Gupta /ID# 275826
RECRUITING

Memphis, Tennessee, 38119, United States
Universitair Medisch Centrum Utrecht /ID# 273398
RECRUITING

Utrecht, 3584 CX, Netherlands

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