Can a new biologic tame lupus flares?

NCT ID NCT06161116

Terminated Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial is testing whether an experimental biologic called MK-6194 can reduce disease activity in adults with systemic lupus erythematosus (SLE), an autoimmune condition that causes inflammation and organ damage. Participants receive either MK-6194 or a placebo as an injection under the skin, alongside their usual lupus medications. The study measures how many people achieve a meaningful improvement in lupus symptoms by week 28, as well as safety and tolerability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MK-6194, an experimental biologic given as an injection under the skin
What this could lead to: If successful, MK-6194 could become a new treatment option to help control lupus disease activity and reduce symptoms.
What could go wrong: This is an early-phase trial with a modest number of participants, so results may not confirm benefit. Possible side effects are still being evaluated.

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

AA Medical Research Center ( Site 0136)

Grand Blanc, Michigan, 48439, United States
ANKARA UNIVERSITY IBNI SINA HOSPITAL-Rheumatology Department ( Site 1703)

Ankara, 06230, Turkey (Türkiye)
AOU Careggi ( Site 1311)

Florence, 50141, Italy
Accurate Clinical Management, LLC. ( Site 0134)

Baytown, Texas, 77521, United States
Accurate Clinical Research, Inc ( Site 0135)

Lake Charles, Louisiana, 70605, United States
Accurate Clinical Research, Inc. ( Site 0133)

Houston, Texas, 77089, United States
Affiliated Hospital of Nantong University ( Site 2027)

Nantong, Jiangsu, 226001, China
Anhui Provincial Hospital ( Site 2043)

Hefei, Anhui, 230071, China
Ankara Bilkent Şehir Hastanesi-Rheumatology ( Site 1702)

Ankara, 06800, Turkey (Türkiye)
Arthritis & Osteoporosis Medical Center - La Palma ( Site 0108)

La Palma, California, 90623, United States
Azienda Ospedale - Università Padova-Department of Medicine-DIMED ( Site 1309)

Padova, Veneto, 35128, Italy
Azienda Ospedaliera Universitaria dell'Università "Luigi Van-UNITA'OPERATIVA DI REUMATOLOGIA, DIPAR ( Site 1305)

Naples, 80131, Italy
Azienda Ospedaliero Universitaria Senese-Medicina Interna e Specialistica ( Site 1306)

Siena, Tuscany, 53100, Italy
Beijing Peking Union Medical College Hospital-Department of Rheumatology and Immunology ( Site 2001)

Beijing, Beijing Municipality, 100730, China
CECIM ( Site 0405)

Santiago, Region M. de Santiago, 8320000, Chile
CELAN,S.A ( Site 0603)

Guatemala City, 01010, Guatemala
CHU Bordeaux Haut-Leveque ( Site 1007)

Pessac, Aquitaine, 33600, France
CHU Montpellier Lapeyronie Hospital-Rhumatologie ( Site 1006)

Montpellier, Herault, 34295, France
CHU Rangueil ( Site 1008)

Toulouse, Haute-Garonne, 31400, France
CHUAC-Complejo Hospitalario Universitario A Coruña-Reumatologia ( Site 1604)

A Coruña, La Coruna, 15006, Spain
Centre Hospitalier Saint Joseph - Saint Luc ( Site 1003)

Lyon, Auvergne-Rhône-Alpes, 69007, France
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord ( Site 1009)

Saint Priest En Jarez, Pays de la Loire Region, 42270, France
Centro Integral de Reumatología del Caribe ( Site 0501)

Barranquilla, Atlántico, 080002, Colombia
Centro Integral en Reumatologia ( Site 0701)

Guadalajara, Jalisco, 44160, Mexico
Centro Internacional de Estudios Clinicos (CIEC) ( Site 0410)

Santiago, Region M. de Santiago, 8420383, Chile
Centro Multidisciplinar de Estudos Clinicos ( Site 0302)

São Bernardo do Campo, São Paulo, 09715-090, Brazil
Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan ( Site 0712)

Mérida, Yucatán, 97130, Mexico
Centro Potosino de Investigación Médica ( Site 0703)

San Luis Potosí City, San Luis Potosí, 78250, Mexico
Centro de Atención en Enfermedades Inflamatorias CATEI ( Site 0707)

Guadalajara, Jalisco, 44638, Mexico
Centro de Estudios de Investigacion Basica y Clinica ( Site 0708)

Guadalajara, Jalisco, 44690, Mexico
Centro de Estudios de Reumatología y Dermatología SAS ( Site 0512)

Cali, Valle del Cauca Department, 760042, Colombia
Centro de Investigaciones Médicas Mar del Plata ( Site 0210)

Mar del Plata, Buenos Aires, 7600, Argentina
Centro de Investigaciones Médicas Tucuman ( Site 0203)

SAN M. de Tucuman, Tucumán Province, T4000AXL, Argentina
Centrum Medyczne Plejady ( Site 1407)

Krakow, Lesser Poland Voivodeship, 30-363, Poland
Chiba University Hospital ( Site 2120)

Chiba, 260-8677, Japan
Clinica Dermacross ( Site 0416)

Santiago, Region M. de Santiago, 7640881, Chile
Clinica Medica Especializada en Medicina Interna y Reumatología ( Site 0601)

Guatemala City, 01010, Guatemala
Clinica de Investigacion en Reumatologia y Obesidad S. C. ( Site 0705)

Guadalajara, Jalisco, 44650, Mexico
Clinica de la Costa S.A.S. ( Site 0502)

Barranquilla, Atlántico, 080020, Colombia
Clinical Research of West Florida, Inc ( Site 0124)

Tampa, Florida, 33606, United States
Clinical Research of West Florida, Inc. (Clearwater) ( Site 0111)

Clearwater, Florida, 33765, United States
Clinstile, S.A. de C.V. ( Site 0709)

Distrito Federal, 06700, Mexico
Clínica Médica Especializada en Pediatría e Infectología Pediátrica - Dr. Mario Melgar ( Site 0602)

Guatemala City, 01009, Guatemala
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0206)

Santa Fe, Santa Fe Province, S3000BPJ, Argentina
Complejo Asistencial Dr. Sotero del Rio ( Site 0402)

Santiago, Region M. de Santiago, 8207257, Chile
DJL Clinical Research, PLLC ( Site 0103)

Charlotte, North Carolina, 28211, United States
Denver Arthritis Clinic ( Site 0102)

Denver, Colorado, 80230, United States
Diex Recherche Sherbrooke ( Site 0003)

Sherbrooke, Quebec, J1L 0H8, Canada
Dokkyo Medical University Hospital ( Site 2118)

Shimotsuga, Tochigi, 321-0293, Japan
Epic Medical Research ( Site 0113)

DeSoto, Texas, 75115, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -UOC Reumatologia ( Site 1304)

Roma, 00168, Italy
Fondazione Policlinico Universitario Campus Bio-Medico ( Site 1307)

Rome, Roma, 00128, Italy
Fundación Valle del Lili ( Site 0506)

Cali, Valle del Cauca Department, 760032, Colombia
Gansu Provincial Hospital ( Site 2065)

Lanzhou, Gansu, 730000, China
HOSPITAL CLINICO DE VALENCIA ( Site 1608)

Valencia, Valenciana, Comunitat, 46010, Spain
Healthy Medical Center S.A.S ( Site 0505)

Zipaquirá, Cundinamarca, 250252, Colombia
Hopital Claude Huriez - CHU de Lille ( Site 1005)

Lille, Nord, 59037, France
Hospital Canselor Tuanku Muhriz UKM ( Site 2225)

Cheras, Kuala Lumpur, 56000, Malaysia
Hospital Quiron Infanta Luisa-Unidad de investigacion de Reumatologia ( Site 1602)

Seville, 41010, Spain
Hospital Taiping ( Site 2221)

Taiping, Perak, 34000, Malaysia
Hospital Tengku Ampuan Afzan-Medical Outpatient Department ( Site 2224)

Kuantan, Pahang, 25100, Malaysia
Hospital Universitari Vall d'Hebron-Rheumatology ( Site 1601)

Barcelona, 08035, Spain
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Rheumatology ( Site 0706)

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario Rio Hortega ( Site 1606)

Valladolid, 47012, Spain
Hospital de Base de São José do Rio Preto-CIP - Centro Integrado de Pesquisas ( Site 0311)

São José do Rio Preto, São Paulo, 15090-000, Brazil
IC La Serena Research ( Site 0414)

La Serena, Coquimbo Region, 1720430, Chile
ICARO Investigaciones en Medicina ( Site 0702)

Chihuahua City, 31000, Mexico
IPC - MT Instituto de Pesquisas Clínicas do Mato Grosso ( Site 0313)

Cuiabá, Mato Grosso, 78020-500, Brazil
IRIS Research and Development, LLC-Research ( Site 0117)

Plantation, Florida, 33324, United States
Iloilo Doctors' Hospital ( Site 2301)

Iloilo City, 5000, Philippines
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 0713)

Mexico City, Mexico City, 14080, Mexico
Instituto de Reumatología ( Site 0201)

Mendoza, M5500CPH, Argentina
Istituto Clinico Humanitas Research Hospital ( Site 1310)

Rozzano, Milano, 20089, Italy
James Lind Centro de Investigacion del Cancer ( Site 0407)

Temuco, Araucania, 4800827, Chile
Japan Community Healthcare Organization Chukyo Hospital ( Site 2107)

Nagoya, Aichi-ken, 457-8510, Japan
Javara - Tryon Medical Partners ( Site 0121)

Charlotte, North Carolina, 28210, United States
Jilin Province People's Hospital ( Site 2033)

Changchun, Jilin, 130021, China
LMK Serviços Médicos S/S-Reumacenter ( Site 0303)

Porto Alegre, Rio Grande do Sul, 90480-000, Brazil
MICS Centrum Medyczne Bydgoszcz ( Site 1410)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-065, Poland
MICS Centrum Medyczne Warszawa ( Site 1411)

Warsaw, Masovian Voivodeship, 00-874, Poland
Mary Mediatrix Medical Center ( Site 2303)

Lipa City, Batangas, 4217, Philippines
Medvin Clinical Research - Metyas ( Site 0128)

Covina, California, 91722, United States
Medvin Clinical Research - Tujunga ( Site 0127)

Tujunga, California, 91042, United States
Medyczne Centrum Hetmańska ( Site 1406)

Poznan, Greater Poland Voivodeship, 60-218, Poland
Morales Vargas Centro de Investigacion ( Site 0710)

León, Guanajuato, 37000, Mexico
Morehouse School of Medicine ( Site 0146)

Atlanta, Georgia, 30310, United States
NHO Chiba Medical Center Chibahigashi National Hospital ( Site 2112)

Chiba, 260-8712, Japan
NZOZ BIF-MED ( Site 1409)

Bytom, Silesian Voivodeship, 41-902, Poland
Nihon University Itabashi Hospital ( Site 2105)

Itabashiku, Tokyo, 173-8610, Japan
Nova Reuma Społka Partnerska ( Site 1405)

Bialystok, Podlaskie Voivodeship, 15-707, Poland
Núcleo de Pesquisa Clínica do Rio Grande do Sul ( Site 0309)

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Okayama University Hospital ( Site 2106)

Okayama, 700-8558, Japan
Osaka Keisatsu Hospital ( Site 2117)

Osaka, 543-8922, Japan
Pingxiang People's Hospital ( Site 2005)

Pingxiang, Jiangxi, 337055, China
Preventive Care ( Site 0507)

Chía, Cundinamarca, 250001, Colombia
Prywatna Praktyka Lekarska Prof. UM dr hab. med. Pawel Hrycaj ( Site 1402)

Poznan, Greater Poland Voivodeship, 61-397, Poland
RM Pharma Specialists ( Site 0711)

Mexico City, Mexico City, 03100, Mexico
Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 2053)

Shanghai, Shanghai Municipality, 200001, China
ST. LUKE'S MEDICAL CENTER ( Site 2304)

Quezon City, National Capital Region, 1102, Philippines
Sakarya Training and Research Hospital-Rheumatology ( Site 1708)

Sakarya, Turkey (Türkiye)
Salud SURA Industriales ( Site 0508)

Medellín, Antioquia, 50021, Colombia
Sanatorio Parque ( Site 0205)

Rosario, Santa Fe Province, S2000DVC, Argentina
Shanxi Bethune Hospital ( Site 2029)

Taiyuan, Shanxi, 030032, China
Shelby Research, LLC ( Site 0142)

Memphis, Tennessee, 38119, United States
Shimane University Hospital ( Site 2119)

Izumo, Shimane, 693-0021, Japan
Showa Medical University East Hospital ( Site 2123)

Shinagawa, Tokyo, 142-0054, Japan
SouthWest Rheumatology Research, LLC ( Site 0115)

Mesquite, Texas, 75150, United States
Southern Medical University Nanfang Hospital ( Site 2037)

Guangzhou, Guangdong, 510515, China
St. Marianna University Hospital ( Site 2121)

Kawasaki, Kanagawa, 216-8511, Japan
Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 2036)

Guangzhou, Guangdong, 510000, China
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 1709)

Kadıköy, Istanbul, 34722, Turkey (Türkiye)
The Affiliated Hospital of Guizhou Medical University ( Site 2051)

Guiyang, Guizhou, 550004, China
The First Affiliated Hospital Of Chengdu Medical College ( Site 2052)

Chengdu, Sichuan, 610500, China
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Te ( Site 2006)

Baotou, Inner Mongolia, 014010, China
The First Affiliated Hospital of Henan University of Science &Technology ( Site 2041)

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Nanhua University ( Site 2061)

Hengyang, Hunan, 421001, China
The First Affiliated Hospital of Xi'an Jiaotong University ( Site 2056)

Xi'an, Shaanxi, 710061, China
The First Afflilated Hospital of Bengbu Medical College-Urology Surgery ( Site 2019)

Bengbu, Anhui, 233000, China
The Second Afilliated Hospital of Hebei Medical University-Immunology And Rheumatology ( Site 2064)

Shijiazhuang, Hebei, 050000, China
Tianjin Medical University General Hospital-Rheumatism and Immunology ( Site 2011)

Tianjin, Tianjin Municipality, 300052, China
Tohoku University Hospital ( Site 2116)

Sendai, Miyagi, 980-8574, Japan
Tongji Hospital Tongji Medical,Science & Technology ( Site 2042)

Wuhan, Hubei, 430000, China
UCSD - Altman Clinical and Translational Research Institute (ACTRI)-Center for Innovative Therapy ( Site 0110)

La Jolla, California, 92037, United States
University Malaya Medical Centre-Clinical Investigation Centre (CIC) ( Site 2222)

Lembah Pantai, Kuala Lumpur, 59100, Malaysia
University of Oklahoma Health Science Center ( Site 0130)

Oklahoma City, Oklahoma, 73104, United States
Yuuai Medical Center ( Site 2122)

Tomigusuku, Okinawa, 901-0224, Japan
Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda ( Site 1408)

Lublin, Lublin Voivodeship, 20-607, Poland

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