New drug MK-1045 enters early human testing for lupus and RA
NCT ID NCT07363590
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tests a new medicine, MK-1045, in about 21 people with lupus or rheumatoid arthritis. The main goal is to see if it is safe and tolerable at different dose levels. Participants receive the drug through an IV infusion, and researchers monitor for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MK-1045 (also called CN201), given as an IV infusion
What this could lead to
If this early study shows MK-1045 is safe, it could lead to a new treatment option for people with lupus or rheumatoid arthritis.
What could go wrong
This is a very small, early-phase trial focused on safety, not effectiveness. The drug may not work or could have side effects. It will take years before any treatment might be available.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ARENSIA Clinics ( Site 0902)
RECRUITINGBucharest, Bucharest, 011658, Romania
Contact Phone: •••-•••-••••
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ARENSIA Exploratory Medicine-Country Emergency Hospital- Arensia,Cluj-Napoca ( Site 0901)
RECRUITINGCluj-Napoca, Cluj, 400006, Romania
Contact Phone: •••-•••-••••
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Anima Diepenbeek ( Site 0601)
RECRUITINGDiepenbeek, Limburg, 3590, Belgium
Contact Phone: •••-•••-••••
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Arensia Exploartory Medicine ( Site 1301)
RECRUITINGTbilisi, 0112, Georgia
Contact Phone: •••-•••-••••
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Chinese Academy of Medical Science Peking Union Medical College Hospital ( Site 1501)
RECRUITINGBeijing, Beijing Municipality, 100005, China
Contact Phone: •••-•••-••••
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Chulalongkorn University ( Site 0501)
RECRUITINGPathumwan, Bangkok, 10330, Thailand
Contact Phone: •••-•••-••••
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Clinica de la Costa S.A.S. ( Site 0101)
RECRUITINGBarranquilla, Atlántico, 080020, Colombia
Contact Phone: •••-•••-••••
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Fundacion Valle del Lili ( Site 0102)
RECRUITINGCali, Valle del Cauca Department, 760032, Colombia
Contact Phone: •••-•••-••••
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Gold Coast University Hospital ( Site 1601)
RECRUITINGSouthport, Queensland, 4215, Australia
Contact Phone: •••-•••-••••
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Istituto Clinico Humanitas- IRCCS ( Site 1902)
RECRUITINGRozzano, Milano, 20089, Italy
Contact Phone: •••-•••-••••
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Keio University Hospital ( Site 0302)
RECRUITINGShinjyuku, Tokyo, 160-8582, Japan
Contact Phone: •••-•••-••••
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Oncomédica S.A.S ( Site 0103)
RECRUITINGMontería, Departamento de Córdoba, 230002, Colombia
Contact Phone: •••-•••-••••
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PMSI Republican Clinical Hospital "T.Mosneaga" ( Site 1001)
RECRUITINGChisinau, 2025, Moldova
Contact Phone: •••-•••-••••
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The University of Tokyo Hospital ( Site 0301)
RECRUITINGBunkyo, Tokyo, 113-8655, Japan
Contact Phone: •••-•••-••••
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UOC Reumatologia ed immunologia clinica ( Site 1901)
RECRUITINGRoma, 00168, Italy
Contact Phone: •••-•••-••••
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UZ Gent ( Site 0602)
RECRUITINGGhent, Oost-Vlaanderen, 9000, Belgium
Contact Phone: •••-•••-••••
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Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1504)
RECRUITINGWuhan, Hubei, 430058, China
Contact Phone: •••-•••-••••