New RA strategy: switch drugs after 12 weeks for better control?

NCT ID NCT05428488

Recruiting now Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests a sequential treatment strategy for rheumatoid arthritis (RA). Participants first receive a TNF inhibitor for 12 weeks, then switch to abatacept. The goal is to see if this approach leads to more remissions than staying on TNF inhibitors alone. The study enrolls 220 adults with active RA despite methotrexate or leflunomide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Abatacept and TNF inhibitor
What this could lead to: If successful, this sequential approach could offer a more effective and better-tolerated way to control rheumatoid arthritis, potentially improving remission rates.
What could go wrong: This is a Phase 3 trial, but results may not confirm the hypothesis. The sequential strategy may not outperform standard TNF inhibitor treatment, and some patients may experience side effects from the medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

APHP Bicêtre
NOT_YET_RECRUITING

Paris, France
APHP Cochin
RECRUITING

Paris, France
APHP La Pitié Salpetrière
RECRUITING

Paris, France
CH du Mans
RECRUITING

Le Mans, France
CHD Vendée
RECRUITING

La Roche-sur-Yon, France
CHR Orléans Nouvel hôpital d'Orléans
RECRUITING

Orléans, France
CHU Bordeaux groupe Pellegrin
RECRUITING

Bordeaux, France
CHU de Brest La Cavale Blanche
RECRUITING

Brest, France
CHU de Nantes
RECRUITING

Nantes, France
CHU de Nice
RECRUITING

Nice, France
CHU de Nîmes Carémeau
NOT_YET_RECRUITING

Nîmes, France
CHU de Strasbourg Hautepierre
NOT_YET_RECRUITING

Strasbourg, France
CHU de Tours - Hopital Trousseau
RECRUITING

Tours, France
Centre Hospitalier Universitaire de Montpellier
RECRUITING

Montpellier, France, 34295, France
Centre Hospitalier de Cahors
NOT_YET_RECRUITING

Cahors, France
Centre hospitalier Princesse Grace
RECRUITING

Monaco, Monaco
Chu Purpan
NOT_YET_RECRUITING

Toulouse, France

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