University Hospital, Montpellier

This study tests whether a procedure to open a blocked carotid artery in the neck, plus standard medical care, helps people recover better from a stroke than standard care alone. About 200 adults with mild to severe stroke symptoms will be randomly assigned to one of two groups. …

This study tests giving a combination of two chemotherapy drugs directly into the liver artery for people with bile duct cancer that has not spread but cannot be removed by surgery. The goal is to see if this approach can shrink tumors after standard treatment has stopped working…

This study tests a new synthetic bone substitute against another material for spinal fusion surgery in adults with degenerative disc disease. About 100 participants will receive one of the two materials during surgery. The goal is to see which leads to better bone fusion and less…

This study tests whether adding addiction monitoring after a liver transplant can reduce the rate of alcohol relapse. About 720 adults who received a liver transplant due to alcohol-related liver disease will be followed for two years. The goal is to see if this extra support hel…

This study tests whether adding a risk prevention program to standard epilepsy education helps adults with uncontrolled epilepsy manage their safety better. About 74 participants will be split into two groups: one gets the extra risk prevention session, the other gets usual care.…

This study is for people recently diagnosed with idiopathic intracranial hypertension (IIH), a condition where high pressure in the brain causes vision loss, headaches, and ringing in the ears. Researchers want to see if placing a small tube (stent) in a narrowed brain vein, alon…

This study is for people with idiopathic intracranial hypertension (IIH) who have been on medication for over a year without enough relief. It tests whether placing a small tube (stent) in a narrowed brain vein can lower brain pressure and ease symptoms like vision loss, headache…

This study tests a new treatment plan for people with rheumatoid arthritis (RA) who still have active disease despite standard medications. The plan starts with a fast-acting drug (TNF inhibitor) for 12 weeks, then switches to a longer-acting drug (abatacept) to try to achieve re…

This study looks at whether using a lower sodium concentration in dialysis fluid can reduce dangerous fluid buildup in ICU patients with acute kidney injury. About 158 adults on a specific type of slow daily dialysis will be randomly assigned to receive either standard high-sodiu…

This study tests whether adding immunotherapy (atezolizumab) and a targeted drug (bevacizumab) before and after standard heat ablation can prevent liver cancer from returning. About 202 adults with small, early-stage liver tumors will be randomly assigned to receive ablation alon…

This study looks at whether a planned hospital stay that screens and treats all of a patient's health problems (like high blood pressure, diabetes, and weight issues) can improve their heart health. About 70 adults at high risk for heart attacks or strokes will take part. The pro…

This study aims to see if a new medical device, which combines a blood test with a short questionnaire, can accurately identify bipolar disorder in people who are currently experiencing a major depressive episode. About 623 adults in primary care will provide a blood sample and a…

This study tests a new, ultra-early, non-invasive method to detect fetal chromosomal abnormalities. Researchers will collect cells from the placenta (extravillous trophoblasts) from 25 pregnant women between 7 and 16 weeks of pregnancy. The goal is to see if this method can provi…

This study looks at whether having regular motivational conversations after leaving the hospital can help people with alcohol use disorder stay away from alcohol for a full year. About 104 adults who have completed alcohol withdrawal in the hospital will take part. Half will get …

This study looks at whether it's safe to avoid placing a bladder catheter during planned cesarean sections. About 550 pregnant women having a planned C-section will be randomly assigned to either get the usual catheter or skip it. The goal is to see if skipping the tube leads to …

This study tests a new type of brain stimulation electrode (CARTESIA™) in 10 people with Parkinson's disease. The goal is to see if using directional stimulation can improve motor symptoms and reduce side effects compared to standard ring-mode stimulation. Participants already ha…

This study tests a new type of talk therapy that helps people with depression correct how they see themselves. It compares this therapy to a standard approach called ACT. The goal is to see if it reduces depression symptoms and prevents relapse over 6 months. About 86 adults with…

This study compares two non-drug programs for chronic low back pain: traditional back school (focusing on spine mechanics) and pain neuroscience education (explaining how the brain processes pain). Researchers will track daily steps with a smartwatch to see which program leads to…

This study tests whether daridorexant, a sleep medication, can safely improve sleep in older adults with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. About 62 participants will take the drug and have their sleep measured in a lab. The …

This study looks at whether people with early-stage oral or throat cancer can have surgery and go home the same day, instead of staying in the hospital. It involves 25 patients and tracks how many need to be admitted or readmitted within 10 days. The goal is to see if outpatient …

This study compares two self-expanding heart valves used in a procedure called TAVR (transcatheter aortic valve replacement). Researchers want to see which valve works better one month and six months after the procedure. About 419 people who need a new aortic valve and can use a …

This study looks at whether sleep problems are linked to faster memory loss in people with early Alzheimer's disease. Researchers will track 132 participants' sleep and memory over time. If a link is found, it could lead to treating sleep issues earlier to possibly slow the disea…

This study looks for rare, hard-to-find DNA changes in people with disorders of sex development (DSD) whose genetic cause is still unknown. Researchers will use a new mapping technique on a blood sample from 20 participants. The goal is to better understand the genetic roots of D…

This study follows 400 adults with serious injuries to find out why some develop chronic pain after leaving the ICU. Researchers will look at medical, psychological, and social factors during the hospital stay. The goal is to create a model that identifies at-risk patients before…

This study aims to validate a simple questionnaire that helps doctors and parents understand how well a child's allergy treatment is working. It involves 135 children aged 5 to 11 with allergic rhinitis. The goal is to create a reliable tool to improve treatment satisfaction and …

This study looks at whether certain chemicals found in everyday products (called endocrine disruptors) increase the chance of a baby boy being born with hypospadias, a condition where the urinary opening is not at the tip of the penis. Researchers will compare mothers of boys wit…

This study follows 400 adults with relapsing-remitting multiple sclerosis for 3 years. Researchers use MRI scans to measure brain shrinkage and compare people on high-efficacy treatments versus medium-efficacy treatments. The goal is to find out which treatment better slows disea…

This study aims to find out how many children with very short height have no known medical cause, and then search for genetic reasons in a small group. Researchers will evaluate 200 children aged 4 to 18 using a team of specialists. For 30 children with confirmed unexplained shor…

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, for two years. Researchers will measure changes in the cornea, vision, and tear proteins, and look at risk factors like eye rubbing and allergies. Some participants will have surgery (cr…

This study looks at 40 women to see if a simple body measurement (anogenital distance) and hormone levels differ between those with severe endometriosis and those without. Participants provide blood and saliva samples before and after watching an empathy-triggering video. The goa…

This study looks at whether a specially trained nurse can effectively screen for neurodevelopmental disorders (like delays in learning or behavior) in children aged 1 to 5 who have congenital heart disease. Researchers will compare the nurse's screening results with a full assess…

This study looks at how where you live and your financial situation might affect your menstrual cycle. Researchers will track hormones, body temperature, and daily symptoms in 320 healthy women from different backgrounds in southern France. The goal is to better understand these …

This study looks at whether a natural cell process called trogocytosis can help predict if CAR-T cell therapy will work for people with a type of blood cancer called diffuse large B-cell lymphoma. Researchers will measure trogocytosis levels in blood samples from 85 patients befo…

This study looks at a protein called BDNF in the spinal fluid and blood of people with Huntington's disease. BDNF helps keep brain cells healthy, and it may be lower in people with Huntington's. Researchers will compare BDNF levels between 135 participants (people with Huntington…

This study looks at eye and vision problems in people with spinocerebellar ataxia (SCA), a rare genetic brain disease that affects movement and coordination. Researchers will examine 60 adults with SCA types 1, 2, 3, or 27B using detailed eye tests to see how often vision loss oc…

This study investigates if parents' exposure to certain chemicals (endocrine disruptors) is linked to cryptorchidism, a condition where a baby boy's testicles don't descend properly. Researchers will compare the jobs and exposures of parents of affected and unaffected boys. The g…

This study involves 12 people with low-grade brain tumors who will have awake surgery. Researchers will record brain activity before and during surgery to see how electrical stimulation affects the brain. The goal is to better understand how these signals travel and which network…

This study aims to find specific blood markers that can tell the difference between hepatitis caused by immune checkpoint inhibitors (a type of cancer immunotherapy) and other forms of autoimmune hepatitis. Researchers will compare blood samples from 60 adults with immunotherapy-…

This study looks at whether a tendency to feel shame can help predict suicide attempts in people with borderline personality disorder (BPD). Researchers will follow 688 adults with BPD for up to 5 years, tracking their shame levels and any suicide attempts. The goal is to better …

This study aims to better understand how blood flows through skin flaps used in reconstructive surgery. Researchers will monitor 20 adults undergoing surgery for pressure sores or limb injuries using special cameras and sensors. The goal is to improve surgical techniques by learn…

This study is testing a new type of mastectomy (breast removal) for breast cancer that uses a small camera and tools through a single cut in the armpit, leaving no visible scar on the breast. It aims to see if this technique is safe and works well for 20 women with small to mediu…

This study is testing whether monitoring a substance in the blood called sST2 can help doctors adjust treatment for people with acute heart failure. The goal is to see if this approach reduces hospital readmissions and improves quality of life. About 710 adults hospitalized for h…

This study tests a new way to manage breathing during lung cancer surgery. Normally, one lung is deflated during surgery, which can cause low oxygen levels and lung damage. The new method uses a tube to measure lung pressure and sets the ventilator to the best setting for each pa…

This study looks at why people with heart failure choose to take part in two different care programs after leaving the hospital: a home support program (PRADO-IC) and remote monitoring via telemedicine. Researchers will follow 700 patients in France to see what factors—like age, …

This study looks at how smoothly people with chronic low back pain can move their spine before and after a rehabilitation program. Using small motion sensors placed on the body, researchers will measure movement quality, not just range of motion. The goal is to find a new way to …

This study looks at whether a program called VigilanS, which involves regular phone check-ins, can prevent suicide by helping people feel more socially connected. Researchers will measure stress responses in 120 adults who have previously attempted suicide. The goal is to underst…

This study aims to find out how many people are allergic to certain foods that contain gibberellin proteins, which can cause severe allergic reactions. Researchers will test 2,000 patients at Montpellier University Hospital using skin prick tests with peach, apple, sesame, carrot…

This study aims to find new biological clues that explain why some people with severe obesity develop type 2 diabetes while others do not. Researchers will collect tissue samples (fat, muscle, liver, blood) from 270 adults during planned weight-loss surgery. By comparing samples …

This study follows 150 people with early hand osteoarthritis to identify early symptoms using ultrasound and MRI. The goal is to predict which patients are at high risk of joint damage seen on X-rays. Participants must be under 60 with symptoms for less than 3 years. The research…

This study looks at how different indoor air and dust pollutants together affect children's allergies and breathing. About 100 schoolchildren will answer health questions, take allergy tests, and do simple breathing tests. The goal is to understand the real-time impact of classro…

This study looks at whether people with Restless Legs Syndrome (also called Willis-Ekbom disease) have overactive nerves that could raise their risk for heart disease. Researchers will measure heart nerve activity and track blood pressure in 40 adults with and without the conditi…

This study is working to make medical lab tests more accurate by improving the materials used to calibrate and check them. Researchers will test these new materials against real patient blood samples for conditions like high bilirubin, cyclosporine levels, and parathyroid hormone…

This study aims to find the gene that causes cutis tricolor, a rare skin condition. Researchers will analyze DNA from 10 patients and their parents (affected or not) to identify genetic changes linked to the disease. The goal is to better understand the condition, not to test a t…

This study looks at tiny particles called extracellular vesicles in the umbilical cord blood of extremely premature infants (born before 28 weeks). Researchers want to see if these particles can help predict serious problems like brain bleeding, lung injury, or death. By analyzin…

This study uses special wearable sensors to measure how people with severe knee osteoarthritis move before and after total knee replacement surgery. Researchers want to better understand movement problems and find simple ways to track improvement. The study involves 20 adults ove…

This study looks at 48 people with chronic leg swelling to see if differences in fat, muscle, and fluid in the leg explain why compression therapy works for some and not others. Participants will have an MRI and genetic testing. The goal is to learn more, not to test a new treatm…

This study compares two ways to perform a lung biopsy for people with undetermined interstitial lung disease. One method uses a breathing tube and general anesthesia, while the other keeps the patient awake with local anesthesia. The goal is to see which approach provides a clear…