University Hospital, Montpellier

This study looks at whether a second islet transplant can safely improve blood sugar control in adults with type 1 diabetes whose first transplant stopped working. Researchers will follow 20 patients for up to 5 years, checking graft function, insulin use, and severe low blood su…

This study looks at whether people with relapsing-remitting multiple sclerosis (RRMS) who are over 40 and have been stable on strong anti-CD20 drugs for at least 3 years can safely switch to milder treatments. The goal is to see if this de-escalation approach prevents disease act…

This study looks at whether adding addiction counseling and monitoring after a liver transplant for alcohol-related liver disease can lower the chance of drinking again. About 720 adults who had a liver transplant for alcohol-related disease will be followed for two years. The go…

This early trial tests whether a single infusion of anti-CD19 CAR T-cells can improve skin thickening and other symptoms in 6 adults with severe, treatment-resistant systemic sclerosis. Participants receive chemotherapy before the infusion and are monitored for 24 months. The stu…

This study compares a nasal high-flow device to standard non-invasive ventilation (NIV) for treating people who come to the emergency room with a severe COPD flare-up and high carbon dioxide levels. Participants are randomly assigned to receive one of the two breathing supports f…

This study compares two surgical techniques for removing tissue left behind after an early miscarriage: hysteroscopy (using a tiny camera to see and remove tissue) and endouterine aspiration (a suction method). About 220 women will be randomly assigned to one of the two procedure…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This study compares two bone substitutes used during spinal fusion surgery for disc degeneration. One is a new material designed to help bones fuse more effectively. Researchers will track 100 adults for 12 months to see if the new substitute improves pain, disability, and fusion…

This study is for people with idiopathic intracranial hypertension (IIH) who have been on the drug acetazolamide for over a year without enough relief. It tests whether placing a small stent in a narrowed brain vein can lower the pressure and improve symptoms like headache and vi…

This study tests whether a procedure to remove a blockage in the neck artery (endovascular treatment) plus standard medical care helps people recover better after a stroke. About 200 adults with acute ischemic stroke from a blocked internal carotid artery will be randomly assigne…

This study tests giving chemotherapy drugs (gemcitabine and oxaliplatin) directly into the liver's main artery for people with advanced bile duct cancer that hasn't spread elsewhere. The goal is to shrink tumors while reducing side effects. About 40 adults who have already tried …

This Phase 3 trial tests a sequential treatment strategy for rheumatoid arthritis (RA). Participants first receive a TNF inhibitor for 12 weeks, then switch to abatacept. The goal is to see if this approach leads to more remissions than staying on TNF inhibitors alone. The study …

This study tests whether placing a small stent in a narrowed brain vein can reduce high pressure inside the skull and improve symptoms like vision loss, headache, and tinnitus. About 114 adults with newly diagnosed idiopathic intracranial hypertension will be randomly assigned to…

This study is testing whether a planned hospital stay that focuses on managing all of a patient's health problems (like high blood pressure, diabetes, and weight) can lower their risk of a future heart attack or stroke. The study will enroll 70 adults who are already at high risk…

This pilot study is testing whether people with early-stage oral or throat cancer (T1-N0 or T2-N0) can safely have their tumor removed as an outpatient, going home the same day. The procedure also includes a sentinel lymph node biopsy to check for cancer spread. Researchers will …

This study compares two sodium levels (140 vs 145 mmol/l) in the dialysis fluid given to ICU patients with acute kidney injury. The goal is to see if the lower sodium level reduces dangerous fluid buildup while still keeping blood pressure stable during treatment. About 158 adult…

This study looks for new ways to diagnose pancreatic cancer, a disease that is often caught too late. Researchers will analyze fluid that is normally thrown away after a standard biopsy procedure. They hope to find proteins or other molecules that could lead to a simple blood tes…

This study investigates whether a blood test (liquid biopsy) can detect prostate cancer early by looking for tumor cells and genetic material in the blood. Researchers will compare blood samples from men with suspected prostate cancer to those without the disease. The goal is to …

This study compares two blood test methods for detecting circulating tumor cells (CTCs) that express a protein called Axl, which is linked to more aggressive cancer. The new technique, called EPIDROP, is being tested against the standard CellSearch method in patients with metasta…

This study aims to see if a new, ultra-early, non-invasive test can accurately detect fetal chromosomal abnormalities using cells from the placenta. Researchers will enroll 25 pregnant women between 7 and 16 weeks of pregnancy. The goal is to develop a safer, earlier alternative …

This study is testing a new tool that combines a blood test with a questionnaire to help primary care doctors correctly identify bipolar disorder in people who are currently experiencing depression. The goal is to see if this tool can accurately tell the difference between bipola…

This study aims to find hidden genetic changes in people with disorders of sex development (DSD) whose standard genetic tests came back normal. Researchers will use a new technique called Optical Genome Mapping on a blood sample from 20 participants. The goal is to see if this me…

This study tests whether daridorexant, a sleep medication, can improve sleep in people with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. Sixty-two participants will receive either the drug or a placebo for one month, and their sleep wi…

This study is testing whether giving patients unlimited access to a secure website with an explanatory video about thyroid surgery can lower their anxiety before the operation. About 220 adults scheduled for thyroid surgery will take part. Researchers will measure anxiety using s…

This study tests whether L-dopa, a drug used for Parkinson's, can improve movement and communication in children with a rare genetic disorder called CTNNB1 syndrome. The condition causes developmental delays, muscle stiffness, and trouble walking. Seven children aged 1 to 15 will…

This study tests whether women having a planned C-section can safely skip the routine bladder catheter. Instead, they will urinate on their own just before surgery. The goal is to see if this approach avoids the need for a catheter after birth, while also improving comfort. About…

This study tests a new way to remove breast cancer through a single small cut in the armpit, leaving no visible scar on the breast. It is for women with small to medium breasts who need a mastectomy but want to keep their nipple. The procedure uses standard laparoscopic tools, ma…

This study tests whether a newer 'directional' brain stimulation method works better than the standard 'ring' method for people with Parkinson's disease. Ten participants who already have deep brain stimulation electrodes implanted will try both modes. The goal is to see which on…

This study tests a new type of talk therapy called Correct Self-Identification Program for people with major depression. 86 adults will be randomly assigned to either this new therapy or a standard therapy (ACT). The goal is to see if the new therapy reduces depression symptoms m…

This study compares two non-drug education programs for adults with chronic low back pain. One program teaches about pain science (Pain Neuroscience Education), while the other focuses on back mechanics (Back School). The main goal is to see if the pain science program leads to m…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find unique biological markers that could …

This study collects extra blood and bone marrow samples from people receiving CAR-T cell therapy for lymphoma or acute lymphoblastic leukemia. The goal is to build a biobank that researchers can use to investigate why about half of patients do not respond to this treatment. Parti…

This pilot study looks at how progesterone levels change after using a hormone shot (hCG) to trigger ovulation in women preparing for frozen embryo transfer. Forty women will give blood samples over six days to track their hormone patterns. The goal is to learn if hCG affects the…

This study looks at how where you live and your financial situation affect your menstrual cycle. Researchers will track hormones, body temperature, and daily symptoms in 320 women from different backgrounds in southern France. The goal is to understand how factors like pollution …

This study tests a new idea: that Borderline Personality Disorder (BPD) may be a form of addiction to close relationships, similar to substance use disorders. Researchers will give a special questionnaire to 194 people—those with BPD, those with bipolar disorder, and healthy volu…

This study follows 1,200 families who already have a child with autism (high-risk group) and 500 families from the general population (low-risk group) starting from early pregnancy. Researchers collect biological samples and survey data to explore how genetics, environment, diet,…

This study is testing whether a blood test can predict how well CAR-T cell therapy works in people with diffuse large B-cell lymphoma. Researchers will take blood samples before and after treatment to look for a specific immune cell activity called trogocytosis. The goal is to fi…

This study is testing whether a blood test that looks for cancer DNA (called a liquid biopsy) can find leftover cancer cells after surgery in people with stage III colorectal cancer. The goal is to see if this test can help doctors decide who needs additional treatment and who ca…

This study follows 500 adults in the Languedoc-Roussillon region of France who have or are suspected of having a blood cancer (hematologic malignancy). Researchers will collect medical records, blood samples, and quality-of-life questionnaires to track survival at 2, 5, and 10 ye…

This study follows 750 severely or morbidly obese patients who have undergone bariatric surgery at a single hospital in France. Researchers aim to track long-term weight loss and improvements in related health issues such as diabetes and high blood pressure. By observing real-wor…

This study is testing whether a blood test that looks for cancer DNA (called ctDNA) can find leftover cancer cells after surgery in people with colorectal cancer that has spread to the liver. The goal is to see which test works best at predicting if the cancer will come back. Thi…

This study is testing a new technique called EXPEL to find biomarkers for pancreatic cancer. Researchers will analyze the fluid used to preserve biopsy samples from 200 patients with suspected pancreatic cancer. The goal is to identify proteins and other molecules that could help…

This study looks at liver inflammation (hepatitis) that can occur in cancer patients treated with immune checkpoint inhibitors, a type of immunotherapy. Researchers aim to describe the different patterns of liver injury and how they respond to treatment. By collecting real-world …

This study investigates whether blood sugar patterns, measured continuously with a wearable sensor, can predict serious heart problems in the year following a heart attack. Researchers will enroll 850 people hospitalized with acute coronary syndrome and track their glucose levels…

This study uses small body-worn sensors to measure how smoothly people with chronic low back pain move their spine during bending and twisting. Researchers want to see if movement fluidity improves after a 10-day rehab program and if it relates to how much disability people repor…

This study tests whether induced pluripotent stem cells (iPS cells) can repair damaged lung tissue from people with COPD. Researchers will take small lung samples from 50 participants (COPD patients, smokers without COPD, and non-smokers) during a routine bronchoscopy. In the lab…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study aims to find out how many children with very short height have no known medical cause, and then search for genetic reasons in a small group. Researchers will evaluate 200 children aged 4 to 18 using a team of specialists. The goal is to better understand why some child…

This study uses small wearable sensors to measure how people with severe knee osteoarthritis move before and after total knee replacement surgery. Researchers will track 20 patients over age 60 to see if these sensors can detect changes in knee motion and pain. The goal is to fin…

This study looks at why some heart failure patients choose to join programs that help coordinate their care after leaving the hospital, like the PRADO-IC program or telemedicine monitoring. Researchers will follow 700 patients in France to see what factors—such as social, cultura…

This study uses special cameras and probes to measure blood flow and oxygen levels in skin flaps during reconstructive surgery. Researchers will study 20 adults having surgery to repair wounds from pressure sores or limb injuries. The goal is to better understand how blood supply…

This pilot study compares two ways to perform a lung biopsy for people with undetermined interstitial lung disease. One method uses a breathing tube and deep anesthesia (standard), while the other uses only mild sedation and numbing medicine. The goal is to see if the gentler met…

This study compares two self-expanding heart valves used in a procedure called TAVR, which replaces a narrowed aortic valve without open-heart surgery. Researchers will look at how well each valve works one month and six months after the procedure in about 419 patients. The goal …

This study tests a personalized 'open lung' breathing method during lung cancer surgery to see if it prevents low oxygen levels better than standard care. The method adjusts air pressure based on each patient's lung stiffness. 120 adults scheduled for lung cancer removal will be …

This study aims to find out why some people who have been through a serious accident or injury go on to have long-lasting pain. Researchers will follow 400 adults in the hospital, looking at medical, emotional, and social factors. The goal is to create a model that can identify w…

This study looks at tiny particles called extracellular vesicles in the umbilical cord blood of extremely premature babies (born before 28 weeks). Researchers want to see if these particles can help predict serious problems like brain bleeding, lung injury, or death. The goal is …

This study looks at a protein called BDNF, which helps keep brain cells healthy, in people with Huntington's disease. Researchers will measure BDNF and related markers in spinal fluid and blood, and compare them to healthy controls. The goal is to find biological signs that could…

This study looks at how indoor air and dust pollutants in classrooms impact children's allergies and lung function. Researchers will monitor 100 children, comparing those with allergies to those without, using questionnaires, allergy tests, and breathing tests. The goal is to ide…

This study is testing a simple questionnaire to see how well it measures allergic rhinitis (hay fever) control in children aged 5 to 11. The goal is to give doctors a reliable way to track symptoms and adjust treatments. About 135 children will fill out the questionnaire during a…

This study looks at whether exposure to certain chemicals (endocrine disruptors) during pregnancy increases the chance of a baby boy being born with hypospadias, a condition where the opening of the urethra is not at the tip of the penis. Researchers will compare 100 mothers of b…

This study looks at how spinocerebellar ataxia (SCA) affects the eyes and vision. Researchers will examine 60 adults with SCA types 1, 2, 3, or 27B, including those with early symptoms and those who are not yet symptomatic. The goal is to measure vision changes and eye damage usi…

This study aims to identify specific blood markers that can distinguish hepatitis caused by immune checkpoint inhibitors from other types of autoimmune hepatitis. Researchers will collect blood samples and liver tissue from 60 adults receiving immunotherapy. The goal is to improv…

This study looks at whether sleep issues are connected to memory loss in people with early Alzheimer's disease. Researchers will track 132 participants over time, measuring their sleep patterns and cognitive function. The goal is to see if treating sleep problems early could help…

This study will test 2,000 allergy patients at Montpellier University Hospital for sensitivity to six foods containing gibberellin-related proteins (GRPs): peach, apple, sesame, carrot, lemon, and orange. Using skin prick tests with raw foods, researchers aim to find out how comm…

This study looks at whether parents' exposure to certain chemicals (endocrine disruptors) in their jobs or during pregnancy is linked to cryptorchidism (undescended testicles) in male children. Researchers will compare exposure levels between parents of boys with and without the …

This study tests whether adding a risk prevention program to standard epilepsy education helps adults with uncontrolled epilepsy improve their safety behaviors. 74 participants will be split into two groups: one gets the extra risk prevention session, the other gets usual care. T…

This study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …

This study is looking for the gene or genes that cause cutis tricolor, a rare skin condition with patches of different colors. Researchers will analyze DNA from blood and skin samples of 10 patients and their parents. The goal is to find genetic changes that might explain the con…

This study looks at whether monitoring a blood marker called sST-2 can help doctors adjust treatment for people with acute heart failure. The goal is to see if this approach reduces hospital readmissions and improves quality of life. Researchers will compare patients whose treatm…

This study looks at whether people with Restless Legs Syndrome (also called Willis-Ekbom disease) have overactive nerve signals that could raise their risk for high blood pressure and heart disease. Researchers will measure heart nerve activity using a special scan, along with bl…

This study aims to improve the accuracy of medical lab tests by creating better reference materials and quality controls. Researchers will compare how these materials behave compared to real patient samples in multiple labs. The goal is to ensure test results are consistent and t…

This study follows 688 adults with borderline personality disorder (BPD) for 5 years to see if feeling shame can predict suicide attempts. Researchers will also look for biological markers and protective treatments. No new drug or therapy is being tested—this is purely an observa…

This study looks at how a telephone support program called VigilanS helps prevent suicide in people who have previously attempted it. Researchers think the program works by restoring social bonds, especially in those who feel isolated. 120 adults aged 18 to 55 who are already par…

This study follows 150 people with early hand osteoarthritis to see if imaging techniques like ultrasound and MRI can predict which patients will get worse over time. Researchers will track joint changes on X-rays and look for links to symptoms like pain and swelling. The goal is…

This study looks at how electrical pulses used by surgeons during awake brain surgery affect the brain. Researchers will measure brain waves in 12 people with low-grade glioma before and after tumor removal. The goal is to better understand which brain networks are turned off by …

This study explores whether an advanced practice nurse can effectively screen for neurodevelopmental disorders (like learning or behavior problems) in children aged 1 to 5 who have congenital heart disease. Researchers will compare the nurse's screening results with a full assess…

This study follows 400 people with relapsing-remitting multiple sclerosis to see how their brains change over three years. Researchers will use MRI scans and blood tests to compare those on high-efficacy treatments versus medium-efficacy ones. The goal is to understand which trea…

This study follows 200 people with keratoconus, a condition that thins and bulges the cornea, over two years. Researchers will track changes in vision, corneal shape, and thickness, and analyze tear proteins to better understand how the disease progresses. Some participants will …