University Hospital, Montpellier

This trial tests whether high-flow nasal cannula oxygen or noninvasive ventilation works better than standard oxygen therapy for ICU patients with acute respiratory failure. About 1,470 adults will be randomly assigned to one of the three methods. The main goal is to see which ap…

This study looks at people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are in deep remission. It compares two methods for gradually increasing the time between infliximab infusions: one based on symptoms and one based on drug levels in the blood. T…

This study tested whether using a Freestyle Libre 2 continuous glucose monitor for 28 days, along with standard therapeutic education, helps people recently diagnosed with type 2 diabetes improve their blood sugar control. The trial enrolled 27 adults diagnosed within the past ye…

This trial tests whether performing balloon aortic valvuloplasty without the blood thinner heparin reduces serious bleeding and blood vessel complications. About 94 adults with severe, symptomatic aortic stenosis will be randomly assigned to receive either heparin or a placebo du…

This study tested whether the anti-inflammatory drug colchicine could prevent nerve damage in the heart after a heart attack. About 54 adults who had a first heart attack and underwent artery-opening treatment were given colchicine or a placebo for one month. The trial was termin…

This study looked at whether giving steroids to people hospitalized for a COPD flare-up works better when their blood shows high levels of eosinophils (a type of white blood cell). Researchers compared treatment failure rates between those who got steroids and those who got a pla…

This study tested whether taking oral corticosteroids (prednisone) for about two months after surgery for a chronic subdural hematoma (a slow brain bleed common in older adults) could reduce the chance of the bleed coming back. The trial planned to enroll 162 patients but was ter…

This phase 2 trial tested a liver-directed chemotherapy using idarubicin mixed with lipiodol (a fatty contrast agent) injected directly into the liver artery. The goal was to see if this could control non-spreading liver cancer in 44 patients with cirrhosis. The study was termina…

This study tested a procedure called endoscopic suturing (using the OverStitch device) to narrow the stomach opening in people who regained weight after gastric bypass surgery. The goal was to see if this minimally invasive stitch could help them lose weight again compared to sta…

This study aimed to compare a standard sleeve gastrectomy (removing part of the stomach) with a modified version called N-Sleeve, which adds a wrap around the top of the stomach to prevent acid reflux. The trial was designed for people with severe obesity and GERD, but only 2 pat…

This study tested whether using a smartphone app and a hand grip device could help people with rheumatoid arthritis manage their condition with fewer in-person doctor visits. About 94 adults with active rheumatoid arthritis were randomly assigned to use the app or continue standa…

This study tested a mobile telerehabilitation program called Telemouv in 50 adults with obesity (BMI over 30). Participants used the app for three months to encourage healthy behavior changes and fat loss. The trial was terminated early, so we don't have final results on whether …

This study looked at whether a procedure to remove large blood clots from the brain could help people who had a severe stroke. It included 335 adults with a large stroke who could be treated within 7 hours. The goal was to see if the procedure reduced disability compared to stand…

This study tests a new blood test called EPIDROP that looks for live circulating tumor cells in men with metastatic prostate cancer. The test uses a special technique to isolate single cells and measure their activity. Researchers want to see if EPIDROP is as good as or better th…

This study investigates whether MRI can be used instead of CT to diagnose the cause of acute abdominal or pelvic pain in women aged 18-40 after an ultrasound has not provided a clear answer. Participants receive both an MRI and a CT scan, and researchers compare how well each tes…

This study looked at whether measuring oxygen levels in the brain and gut using a light-based device (NIRS) could help doctors diagnose necrotizing enterocolitis (NEC) earlier in newborns with symptoms like bloody stool or a swollen belly. The study planned to include 45 newborns…

This study tested a new blood test that looks for fetal cells in the mother's blood to diagnose genetic diseases in the baby. It aimed to replace invasive tests like amniocentesis, which carry a small risk of miscarriage. The trial enrolled 18 pregnant women but was terminated ea…

This study looked at whether a third-trimester ultrasound can accurately find bowel rotation issues in fetuses that raise the risk of a life-threatening twist (volvulus). Researchers compared ultrasound results with fetal MRI, the current best method. The study included 77 pregna…

This study investigates whether giving patients personalized, secure access to a web platform with an explanatory video about their upcoming breast cancer surgery can lower their anxiety. Participants are women with breast cancer scheduled for lumpectomy, oncoplasty, or mastectom…

This study tested whether a digital platform (m-Rehab) could help people with ALS who use non-invasive ventilation. The platform included educational content, remote monitoring, and video consultations. The goal was to see if it could slow the loss of physical function and improv…

This study tested whether using lung ultrasound to adjust ventilator pressure could improve oxygen levels in people with blunt chest trauma. Nineteen adults with rib fractures or lung bruises who needed breathing support were enrolled. The trial was terminated early, so the findi…

This study tested a sensory rehabilitation program for people who lost their sense of smell or taste after chemotherapy for blood cancers like multiple myeloma or lymphoma. The program involved exercises to retrain the nose and tongue. Only 5 people enrolled before the study ende…

This pilot study tested a special helmet and abdominal panel that shines near-infrared light and uses a static magnetic field on people with mild-to-moderate Alzheimer's disease. The goal was to see if it could safely improve memory and thinking. The study planned to enroll 60 pa…

This study aimed to identify brain areas outside the main motor region that help arm recovery after a severe stroke. Researchers followed 28 patients over time, using MRI and movement tracking to see which brain areas became active as arm function improved. The goal was to find n…

This study looked at why exercise training improves blood vessel function less in some people with COPD than in healthy individuals. Researchers measured blood vessel health before and after a 4-week exercise program in 69 participants, including COPD patients and healthy volunte…

This study looked at three different breathing tests (spontaneous breathing trials) used to see if ICU patients are ready to have their breathing tube removed. Researchers measured how hard patients had to work to breathe during each test. The goal was to find which test works be…

This study followed 216 Air France employees working at Paris and Marseille airports to see if tiny particles from aircraft engines affect their breathing over 5 years. Researchers measured lung function and exposure to nanoparticles. The goal was to understand any link between t…

This study tested a serious game called Bipolife® for people with bipolar disorder who had already completed a psychoeducation program. The game encourages players to take their medication, keep a daily routine, and contact their doctor if symptoms return. The trial was terminate…

This study looked at whether a newer, low-dose X-ray system (EOSedge) produces images good enough for planning hip replacement or revision surgery, compared to standard digital X-rays. About 97 adults who needed hip surgery X-rays took part. The goal was to see if using just one …

This study looked for new markers in blood and joint fluid to help doctors tell the difference between septic arthritis (a joint infection) and juvenile idiopathic arthritis (an inflammatory condition) in children. Researchers planned to analyze samples from 100 children under 15…

This study looked at whether measuring two proteins in the blood (S100B and copeptin) can help doctors decide if a child with a head injury needs a CT scan. Many children get CT scans that are normal, exposing them to radiation. The study enrolled 167 children aged 3 months to 15…

This study followed 190 young women to learn how the body handles new HPV infections. Researchers measured virus levels, immune cells, and other factors over time. The goal was to understand why some infections clear quickly while others persist. No treatment was given; this was …

This study looked at muscle samples from 7 children with brachial plexus birth palsy who had shoulder stiffness. Researchers wanted to understand why the shoulder gets stiff again after surgery, by checking for muscle wasting and scarring. The study was terminated early, so findi…

This study looked at why some people have more suicidal thoughts when they start or switch antidepressants. 38 adults with major depression used a smartphone app to rate their dark thoughts and mood daily for 30 days. The goal was to better understand and monitor this early risk …

This study looked at whether a brain wave test called mismatch negativity (MMN) can measure how well adult cochlear implant users can tell apart similar sounds. Researchers compared the brain wave results to a standard hearing test using made-up words (logatoms). The goal was to …

This study looked at how JAK-STAT inhibitors, a type of drug used for rheumatoid arthritis, affect certain immune cells called regulatory B cells. Researchers analyzed blood samples from 27 patients to see if these drugs could boost anti-inflammatory functions. The study was term…

This pilot study analyzed special immune cells called regulatory T cells (Tregs) in the joint fluid of 19 people with rheumatoid arthritis during a flare-up. Researchers compared these cells to Tregs in the blood to understand how they behave in inflamed joints. No treatment was …

This study looked at whether an early heart MRI can help doctors know which patients with severe heart damage after a heart attack will get better on their own. The goal was to see if MRI could identify patients who would benefit from getting a defibrillator sooner rather than wa…

This study aimed to test a device called CerviStab that measures how well rugby players' neck muscles respond to sudden impacts. Researchers wanted to see if the device could reliably measure head movement and muscle strength in healthy volunteers and compare them to rugby player…

This study aimed to see if a new type of genetic therapy could fix a specific problem in the CFTR gene that causes cystic fibrosis. Researchers took nasal and rectal cell samples from 16 patients and tested the therapy in the lab. The study was terminated early, so we don't have …