University Hospital, Montpellier

This trial investigates whether adding hypnosis sessions to standard dietary monitoring can help people lose weight after bariatric surgery has not worked. About 25% of patients do not achieve lasting weight loss from surgery alone. The study enrolls 60 adults aged 18-65 with obe…

This trial compares two types of surgery for pancreatic cancer in the body or tail of the pancreas: minimally invasive (laparoscopic or robot-assisted) versus traditional open surgery. The goal is to see if the less invasive approach can remove the tumor just as completely. Adult…

This study tested whether giving sodium bicarbonate (a common substance that neutralizes acid) to critically ill patients with severe metabolic acidosis and moderate-to-severe acute kidney injury could improve survival at 90 days. The trial enrolled 640 adults in the ICU who had …

This study tested whether giving sodium bicarbonate (a common buffer) to critically ill patients with severe metabolic acidosis helps them survive and recover. 400 ICU patients with low blood pH and high lactate were randomly assigned to receive either sodium bicarbonate or no bu…

This study looked at whether using a non-invasive ventilation (NIV) mask right after removing a breathing tube can prevent respiratory failure in obese intensive care patients. About 1000 obese adults were randomly assigned to receive either NIV or oxygen therapy. The goal was to…

This study tested whether giving erythropoietin (EPO) and an iron injection before heart surgery could lower the number of patients needing blood transfusions. 128 adults scheduled for heart surgery who were at high risk of transfusion took part. The approach aimed to boost hemog…

This study tests whether a therapeutic education program helps teenagers and young adults with congenital heart disease transition from pediatric to adult medical care. Participants aged 13 to 25 will either receive the education program or standard follow-up. Researchers will me…

This study tested whether measuring oxygen levels in the blood (ScvO2) can help doctors decide when to give blood transfusions to anemic patients after heart surgery. 100 patients were randomly assigned to receive transfusions based on standard guidelines or only if their ScvO2 w…

This study tests whether using telemedicine (remote doctor visits) helps heal chronic wounds better than usual in-person care. Adults with long-lasting wounds in the Languedoc-Roussillon region of France are randomly assigned to telemedicine or standard treatment. The main goal i…

This study tested whether adding a telerehabilitation program (using a mobile app, video calls, and online coaching) to standard CPAP therapy helps obese adults with severe sleep apnea. 180 participants were followed for 6 months to see if the program improved daytime sleepiness,…

This study tested whether a smartphone chatbot called Vik-Asthme can teach adults with asthma how to manage their condition as well as the usual in-person training. 73 adults with asthma were split into two groups: one received standard education, the other used the chatbot. Rese…

This study looked at whether giving protein supplements after sleeve gastrectomy surgery helps patients keep their muscle mass while losing weight. 90 obese adults who had the surgery took part. Researchers measured changes in lean body mass and other health markers over 5 weeks.

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This study tested whether implanting a new aortic valve (TAVI) without first using a balloon to open the narrowed valve is safer and as effective as the standard procedure with balloon predilatation. 250 adults with severe aortic stenosis who were at high risk for open-heart surg…

This study compared two types of dialysis in 415 older adults (ages 65-90) with chronic kidney failure: online hemodiafiltration and conventional hemodialysis. The goal was to see which method is better tolerated and whether it reduces heart problems and other complications. Pati…

This study tested two ways to treat bullous pemphigoid, a severe blistering skin condition. One group used strong steroid creams for 9 months, while the other used steroids plus methotrexate for 4 weeks, then methotrexate alone for 8 months. The goal was to see if the combination…

This study tested a new surgical method for immediate breast reconstruction after preventive mastectomy in women at high genetic risk for breast cancer. Instead of a scar on the breast, surgeons used a single-port endoscope through the armpit to place the implant under the skin, …

This study looked at whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) in people who have had a kidney transplant and have chronic kidney disease. Researchers followed 55 patients for 6 months to see if the drug lowered protein levels and prote…

This study looked at whether closer collaboration between doctors and pharmacists could reduce hospital readmissions for people with heart failure. About 229 adults hospitalized for heart failure took part. Researchers compared standard care to a more coordinated approach where p…

This study tested whether using a measure of oxygen in the blood (SvO2) to guide red blood cell transfusions during heart surgery could reduce how many patients receive transfusions. Over 600 adults undergoing on-pump cardiac surgery were randomly assigned to either standard rest…

This study looked at whether regularly measuring levels of anti-TNF drugs and antibodies in the blood can help doctors better manage inflammatory bowel disease (Crohn's and ulcerative colitis). 260 patients were split into two groups: one where doctors used these test results to …

This study tested whether using a mask that helps with breathing (non-invasive ventilation) can prevent the need for a breathing tube in patients who develop respiratory failure after abdominal surgery. 300 adults who had abdominal surgery and then had trouble breathing were rand…

This study tested a program called PRADO that helps heart failure patients transition from hospital to home care. It included 404 adults who had been hospitalized for heart failure and lived at home. The program aimed to reduce hospital readmissions and deaths by coordinating doc…

This study tested whether a mobile telerehabilitation app could help people with COPD keep the benefits they gained from a short pulmonary rehab program. 200 patients were randomly assigned to use the app or receive standard care for one year. The main goal was to see if the app …

This study tested a mobile app called EkiYou V2 that helps people with diabetes figure out how much insulin to take. 21 adults who use multiple daily insulin injections used the app for 6 weeks. The goal was to see if the app safely improves blood sugar control and makes insulin …

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

This study looked at nearly 500 patients who had a paracetamol (acetaminophen) allergy test over 22 years. The goal was to find the smallest dose that triggers a reaction, so future tests can be shorter and safer. By analyzing past data, researchers hope to create a simplified te…

Heart failure is a serious condition with high death and rehospitalization rates. This study tested whether using a blood marker called ST2 to guide treatment could reduce hospital readmissions within one month. Researchers compared standard care with a strategy that adjusts medi…

This study tested a new blood test designed to quickly determine whether the complement system is involved in a serious kidney condition called thrombotic microangiopathy (TMA). The test measures complement deposits on cells in a lab sample. Researchers compared test results to h…

This study tested a new saliva-based test for SARS-CoV-2 that gives results in less than an hour, without needing lab equipment. Researchers compared it to the standard PCR method using samples from 627 people, including healthcare workers and patients. The goal was to see if thi…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, compared to the current standard of testing spinal fluid. Researchers measured specific proteins in the blood of 342 adults visiting memory clinics. The goal was to see if these blood markers c…

This study tested whether a fluorescent dye called indocyanine green (ICG) can help surgeons locate small, non-palpable breast tumors during surgery. Ten women with early-stage breast cancer received both the dye and a standard radioactive seed, and doctors compared how well each…

This study aimed to develop a non-invasive prenatal test using fetal cells from a mother's blood to detect triplet repeat diseases like Huntington's disease, Fragile X syndrome, and certain types of muscular dystrophy and ataxia. Researchers enrolled 60 pregnant women at risk and…

This study aimed to create better diagnostic tools for a type of heart failure called heart failure with preserved ejection fraction (HFpEF), which is common in older adults but hard to diagnose. Researchers tested a combination of five blood markers in 91 participants to see if …

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study tested whether offering a vaginal self-sampling kit directly to women aged 50-65 who had not had a cervical smear in over three years would increase screening participation. Women received a kit to use at home and mail to a lab for HPV testing. The goal was to see how …

This study tested whether early osteopathic treatment in newborns with risk factors (like a preferred head turn or muscle tightness) could prevent positional skull deformities (flat head). 101 babies were randomly assigned to receive either osteopathic sessions plus standard advi…

This study tested a balloon catheter to open blocked Eustachian tubes in 31 adults. The device is inserted into the tube and inflated to widen it. Researchers measured changes in ear symptoms over 14 months to see if the procedure provides lasting relief.

This study tested a 20-minute neck-strengthening program in 50 amateur rugby players to see if it could speed up their neck muscle reactions to head impacts. The program used isometric contractions and stroboscopic glasses to improve visual processing and reflex force. Researcher…

This study tested two methods of delivering epidural pain medication during labor in 304 first-time mothers. One method gave a steady drip of pain relievers, while the other gave small, timed bursts. The goal was to see which approach led to fewer delivery complications, such as …

This study looked at 300 infants under 6 months old with severe bronchiolitis in the pediatric ICU. Researchers compared two flow rates of high-flow nasal cannula (2 vs 3 liters per minute per kilogram) to see which one reduced breathing failure within 24 hours. The goal is to fi…

This completed study tested whether combining a gentle brain stimulation technique (HD-tDCS) with virtual reality therapy could help people who had a stroke more than three months ago recover arm function. Fifty-eight participants received either real or sham stimulation during V…

This study tested whether a nerve block called the pectoral block (Pecs block) can reduce pain after cosmetic breast augmentation. 74 women scheduled for surgery were randomly assigned to receive either the block or a sham procedure. The main goal was to see if the block lowered …

This small pilot study tested whether using a special ear electrode for 30 minutes each day could help people with long-lasting low back pain. The device gently stimulates the vagus nerve, which is known to affect pain and mood. Thirty adults with chronic low back pain that hadn'…

This study tested whether listening to music during a daily cleaning procedure can reduce pain in children aged 6 months to 15 years in a pediatric intensive care unit. Each child experienced the cleaning twice—once with music and once without—and pain was measured using a standa…

This study tested two different nerve blocks for pain after hallux valgus (bunion) surgery. One group received a standard sciatic block, while the other received a plantar block combined with a distal peroneal block. The goal was to see which approach allows patients to walk bett…

This study tested whether a single injection of platelet-rich plasma (PRP) into the spinal disc could reduce pain and improve function in people with chronic low back pain caused by active discopathy. 126 adults aged 18 to 60 with at least 3 months of pain received either PRP or …

This study tested a new mindful eating program designed for French adults with overweight or obesity. Fifty-six participants joined group sessions and home exercises to improve their eating awareness. The goal was to see if the program could increase mindful eating and reduce anx…

This study tested whether electronic distractions like music, virtual reality, or TV can reduce discomfort in ICU patients. Sixty awake, non-delirious adults tried each device for 15 minutes. Researchers measured changes in pain, anxiety, thirst, shortness of breath, and insomnia…

This study tested whether adding a powerful morphine-like drug (Ultiva) to the standard numbing medicine (Xylocaine) could make the feticide procedure faster and less painful for the fetus. 66 women undergoing late-term pregnancy termination (after 22 weeks) took part. The main g…

This study tested an 8-week mindfulness program (MBSR) in 40 adults with painful hip or knee osteoarthritis. Participants learned to focus on the present moment to better manage chronic pain. The goal was to see if mindfulness could reduce pain and improve daily function compared…

This study tested whether using a virtual reality headset is as good as standard equipment for improving balance in people with vertigo. 76 adults with vestibular disorders completed a 3-4 week rehabilitation program. The goal was to see if the cheaper, smaller VR device could ma…

This study tested a group-based cognitive training program for people with schizophrenia who have had the condition for less than 10 years. The program teaches practical strategies to work around memory, attention, and planning problems. Researchers compared the costs and daily f…

This study tested whether having people with schizophrenia watch a video of themselves recorded during a psychotic episode could improve their awareness of their illness. Sixty patients were randomly assigned to either watch the video or not. The goal was to see if this simple to…

This pilot study tested whether an 8-week mindfulness meditation program could reduce embarrassment from tremor in 21 people with Parkinson's disease. Participants wore a smartwatch to track tremor during daily life. The study aims to see if this approach is worth testing in a la…

This study looks at the DNA of 100 children (and young adults up to age 17) who have cancer, along with the DNA of their healthy parents. The goal is to find genetic changes that may have caused the cancer. By comparing the child's DNA to both parents', researchers hope to discov…

This study looked at how in vitro fertilization (IVF) affects the quality of life of working women. Researchers followed 200 women starting their first IVF treatment, using questionnaires to measure emotional, social, and work-related impacts over up to 18 months. The goal was to…

This study looked at whether a blood test measuring DNA fragments can detect leftover cancer after lung cancer surgery. Researchers followed 133 patients with early-stage lung cancer for one year after their operation. The goal was to see if changes in the DNA test could predict …

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This completed study examined muscle cells from 8 children with obstetrical brachial plexus palsy, a birth injury that affects arm nerves. Researchers took small muscle samples during planned shoulder surgery to see if the cells can repair themselves. The goal was to understand w…

This study looked at 40 women to see if a physical measurement called anogenital distance (AGD) and certain hormone levels differ between those with and without endometriosis. Researchers measured AGD and took blood and saliva samples before and after showing an empathy-inducing …

This study tested whether a CT scan of the lungs could predict which patients with severe eosinophilic asthma would respond well to the drug benralizumab. 59 adults received benralizumab for 48 weeks and had CT scans at the start, middle, and end of treatment. The goal was to see…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study looked at whether using a bendable wire (stylet) inside the breathing tube helps doctors successfully insert the tube on the first attempt in critically ill patients. Over 1,000 adults in intensive care who needed a breathing tube took part. The goal was to see if the …

This study tested a new method to measure how stroke patients use their trunk to compensate for arm weakness during a reaching task. Researchers enrolled 144 hemiparetic patients and used motion analysis to track trunk displacement. The goal was to see if this measurement is reli…

This study followed 150 adults with systemic sclerosis (scleroderma) for two years to track their nutritional health. Researchers measured weight, diet, and disease severity every six months. If malnutrition was found, patients received dietary advice or supplements. The goal was…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This study looked for hidden genetic changes in 10 children with developmental delays who had a balanced chromosomal translocation (a rearrangement of DNA that appears normal under a microscope). Researchers used high-resolution DNA microarrays to check for tiny missing or extra …

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This study tested whether water biking in hot water (35°C) helps athletes adapt to heat better than biking in neutral water (25°C). Twenty-four healthy recreational athletes completed 10 training sessions over two weeks. Researchers measured changes in distance traveled during a …

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study looks at why young women with anorexia nervosa lose bone density. Researchers will compare 160 patients with 160 healthy women to measure bone mass and check hormones and other markers. The goal is to find the key factors behind bone loss, which could lead to better tr…

This study looks at how exercise training affects the growth and maturation of tiny blood vessels in the leg muscles of people with COPD. Researchers will compare healthy volunteers and COPD patients doing different exercise intensities for 5 to 10 weeks. The goal is to understan…

This study aimed to create a personalized 3D computer model of the breast to help surgeons better understand where tumors are located during surgery. Researchers measured skin elasticity and thickness in 200 women, and performed special MRI scans on 10 women in different position…

This study investigates whether tiny molecules in the blood, called miRNAs, can act as markers of lung disease in people with cystic fibrosis. Researchers will compare miRNA patterns between cystic fibrosis patients and healthy volunteers, and also between patients with mild vers…

This study looked at whether a new blood test called EPISPOT can predict how well chemotherapy works in people with metastatic colorectal cancer. Researchers measured circulating tumor cells in 168 patients before and during treatment. The goal was to see if early changes in thes…

This study looked at 120 people with Friedreich's ataxia, a rare genetic disease that causes progressive movement problems. Researchers examined tiny interruptions in the DNA expansion that causes the disease to see if they influence when symptoms start and how severe they become…

This study looked at whether vitamin D levels in the blood are linked to how fast ALS (Lou Gehrig's disease) gets worse. Researchers measured vitamin D in 127 people with ALS and tracked their motor decline, breathing, and weight loss. No treatment was given—the goal was simply t…

This study measured the peak tidal inspiratory flow (PTIF)—how fast infants breathe in—in 50 babies under 6 months old with moderate to severe viral bronchiolitis. Researchers used a spirometer to record 20 breaths per infant within 24 hours of hospital admission. The goal was to…

This study tested whether in-person simulation training—where ICU staff practice handling life-threatening emergencies in their own unit—can improve their quality of work life and teamwork. 90 nurses and nursing assistants took part. The goal was to see if this training reduces b…

This study tested a new way to predict dangerous heart rhythm problems after a common heart valve procedure called TAVR. Researchers combined ECG results with CT scan measurements and implant depth to see if they could safely identify low-risk patients. The study looked back at 2…

This study offered a rapid hepatitis C test to 1,500 women aged 50-74 who were already coming in for breast cancer screening in Montpellier, France. The goal was to see how many women would agree to the extra test and how many had undiagnosed hepatitis C. Women who tested positiv…

This study tested whether a special PET scan can predict delayed brain damage in people who had a bleeding stroke from a burst aneurysm. 35 participants received a PET scan within days of their stroke to measure how their brain cells take up sugar, which reflects blood flow. The …

This study tested whether wrist-worn accelerometers can accurately measure how much stroke patients use their weaker arm during everyday activities like dressing and eating. Twenty-five participants were recorded with both accelerometers and video cameras. The goal was to see if …

This study looked at 72 adults with cystic fibrosis to see if chemical changes in DNA, called methylation, are linked to how well their lungs work. The goal was to understand why lung disease gets worse at different rates in different people. No treatment was given; instead, rese…

This study aims to find DNA markers (epigenetic biomarkers) in sputum that can predict how severe lung disease will become in people with cystic fibrosis. Researchers will collect sputum samples from 50 participants aged 12 to 30 over 18 months and analyze changes in DNA methylat…

This study looks at how a specific gene mutation (RANBP2) affects the immune system in people with Acute Necrotizing Encephalopathy type 1 (ANE1), a rare brain condition triggered by infections. Researchers compared blood samples from 35 participants, including patients with the …

This study tested a strategy to decide which patients need additional artery-opening treatment after a TAVI heart valve procedure. Researchers used a special imaging scan (SPECT) to look for areas of the heart not getting enough blood. The goal was to see if this imaging-guided a…

This study looked at 218 people with severe aortic stenosis (a narrowed heart valve) who needed a procedure called TAVI to replace the valve without open-heart surgery. Researchers compared two approaches: general anesthesia (being fully asleep) versus local anesthesia with sedat…

This completed study looked at 20 adults with bulimia or binge eating disorder to see if low blood sugar levels trigger eating binges. Participants wore a continuous glucose monitor and kept a food diary for 14 days. The goal was to understand whether blood sugar dips lead to cri…

This study measured the amount of mepolizumab in the blood of 50 adults with severe asthma who were already taking the drug. Researchers compared drug levels between those who responded well to treatment and those who did not. The goal was to see if differences in how the body pr…

This study examined 1400 adults in intensive care to find out what makes intubation difficult. Researchers tracked how many attempts were needed and any complications like low oxygen or heart issues. The goal is to help doctors better prepare for challenging cases and improve pat…

This study tested a 6-week self-management program for people with chronic diseases who also face socioeconomic challenges. The program involved six weekly workshops led by a professional and a peer volunteer, aiming to empower participants to take control of their health. Resear…

This study looked at 407 people with a type of heart attack called NSTEMI to see if getting a heart procedure (coronary angiography) within 24 hours leads to better outcomes. Researchers checked how well following this timing guideline predicted death, another heart attack, strok…

This completed study took blood samples from 4 people with severe asthma or a related condition called ABPA. Researchers used the blood cells to create stem cells and then grew them into tiny models of bronchial tissue. The goal was to see if this lab-grown tissue could mimic rea…

This study looked at 72 healthy male triathletes aged 20-54 who competed in a long-distance triathlon. Researchers checked heart function and rhythm before, during, and after the race to see if intense exercise causes temporary heart strain or irregular beats. The goal was to bet…

This study looked at 43 people with funnel chest (pectus excavatum) to see how corrective surgery changes their heart and lung function during exercise and their overall quality of life. Researchers measured oxygen use, breathing, and symptoms like shortness of breath or heart fl…

This study looked at 28 people with both stable coronary artery disease and moderate sleep apnea. Researchers measured blood markers of oxidative stress (a type of cell damage) before and after 3 months of CPAP therapy. The goal was to see if CPAP could reduce oxidative stress, w…

This completed study measured two proteins in the blood—neurofilament light chain and GFAP—that can signal nerve damage. Researchers compared 15 people with atypical MS, 30 with typical MS, and 15 healthy controls to see if these markers differ. The goal was to better understand …

This study looked at specific cells in the blood of 40 women with either Sjögren's syndrome or systemic sclerosis. The goal was to see if counting these cells could help understand the diseases better. No treatment was given; it was purely an observational study to explore potent…

This study looked at 20 years of data from over 1,200 patients to find the safest and most effective doses for drug provocation tests (DPTs) for beta-lactam allergies. Researchers analyzed past positive tests to create a new, simpler testing protocol. They will now test this new …

This study looked at 60 people with a family history of hypospadias, a birth defect where the opening of the penis is not at the tip. Researchers used DNA sequencing to find new genetic changes linked to the condition. The goal was to discover genes that may cause hypospadias whe…