University Hospital, Montpellier

This phase 2 trial tests whether ursodeoxycholic acid (UDCA), a drug already used for other liver conditions, can treat cholestatic hepatitis—a liver inflammation caused by immunotherapy—better than standard steroids. About 94 adults with cancer (excluding liver cancer) who devel…

This phase 3 trial tests whether giving daily progesterone injections for 6 weeks after a positive pregnancy test can improve live birth rates in women with low progesterone levels. The study includes 214 women aged 18-37 who became pregnant through IVF. Half will receive the ext…

This study tests a new method for setting ventilators during abdominal surgery to prevent postoperative respiratory failure. The approach adjusts settings based on 'mechanical power,' a measure that combines several ventilator parameters. The trial will enroll 490 adults having a…

This study compares two types of dental glue used to attach braces to teeth. One is a traditional three-step system, the other a simpler two-step system. The goal is to see which causes less damage (white spots) to tooth enamel. Thirty-four teenagers will have each type of glue u…

This study compares three common surgical techniques for fixing simple hand fractures: a screw, a plate, or pins. About 111 adults with fractures in the long fingers (excluding the thumb) will be randomly assigned to one method. The goal is to see which approach gives the best ha…

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study will follow 300 adults aged 50 and older with knee osteoarthritis who are scheduled for a 3-week thermal spa treatment. Researchers will use wearable sensors to measure knee movement fluidity before and after the spa program, and at 3 and 12 months later. They will als…

This study tests whether a small nerve stimulation device can reduce pain and the need for morphine after shoulder surgery. Sixty adults will be randomly assigned to receive either standard pain care or the device, which delivers gentle electrical pulses to nerves near the should…

This study tests whether a structured 5-week cardiac rehabilitation program can improve exercise ability and quality of life in 40 adults with cardiac amyloidosis. Participants will undergo supervised aerobic and strength training five days a week, with tests before and after the…

This study tests whether an ultrasound-guided nerve block injection can quickly reduce pain and improve movement in people with sudden, non-specific low back pain. 300 adults with severe pain and trouble walking will receive either a local anesthetic or a saline placebo injection…

This study tests a therapy called CFTSI for children aged 7 to 17 who have experienced a traumatic event in the last 3 months. The goal is to see if CFTSI reduces post-traumatic stress symptoms better than standard supportive therapy. 140 children and their families will take par…

This study tests whether autobiographical rewriting workshops, added to standard therapy, can help people with borderline personality disorder (BPD) function better socially and at work. 140 participants will either take part in these workshops or do non-specific writing sessions…

This study tests whether a smartphone app called emma, used alongside the standard VigilanS program, can reduce suicide events (like attempts or hospital visits) in adults who recently attempted suicide. The app lets users quickly contact crisis support, tracks mood, and offers c…

This study will follow 120 women with twin pregnancies and their 240 children to see how environmental exposures, lifestyle, and diet affect health at birth and during the first year of life. Researchers will collect biological samples and use models to measure exposure to pollut…

This study aims to create stem cell lines from blood samples of 16 people: 4 with severe scleroderma, 4 with mild scleroderma, and 8 of their healthy relatives. These stem cells will be turned into various tissue types (like heart, skin, and immune cells) in the lab to study how …

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can accurately tell benign from malignant lesions and predict cancer spread to lymph nodes. Current methods often lead to unnecessary surgery. The goal is to create a bioban…

This study looks at how temporary noise exposure at levels allowed by law (around 85 dB) affects hearing and thinking in 40 healthy adults aged 18-35. Participants will be exposed to different noise patterns, including with rest breaks, to see if breaks help reduce auditory fatig…

This study will monitor 75 adults—natural short sleepers, normal sleepers, and people with idiopathic hypersomnia—over 32 continuous hours in a sleep lab. Using EEG and actigraphy, researchers will track brain wave patterns and blood sugar changes to understand how the body regul…

This study will follow 10 adults with unruptured brain arteriovenous malformations (AVMs) who are scheduled for surgery. Researchers will use special brain scans to measure blood flow and energy use in different brain regions before and six months after the operation. The goal is…

This study will follow 42 children and teens with cerebral palsy who need surgery for scoliosis (a curved spine). Researchers want to see if the surgery helps them eat more and gain weight, since many have trouble eating and are underweight. The goal is to understand if the surge…

This study looks at whether measuring the thickness (viscosity) of nasal mucus can help doctors better understand the type of inflammation in people with chronic sinusitis and nasal polyps. Researchers will compare mucus from 60 patients having sinus surgery—some with polyps and …

This study looks at why some babies under 3 months get fevers. It will check for viruses in the nose and stool of 130 febrile infants and compare them to healthy babies. The goal is to better tell apart viral and bacterial infections, which could lead to fewer hospital stays and …

This study aims to find the best way to collect and handle stool samples for gut bacteria (microbiota) research. Researchers will compare different collection methods to the standard quick-freeze technique. Ten healthy adults aged 18 to 85 will provide samples. The goal is to imp…

This study looks at a new program that helps children aged 6 to 18 with mild mental health issues get faster care by improving how doctors, nurses, and community providers work together. Researchers will interview healthcare professionals and families to find out what helps or hi…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study looks at how trauma exposure relates to suicidal thoughts and behaviors in teenagers aged 11 to 17 who are in psychiatric hospitals. Researchers will compare teens admitted for suicide attempts with those admitted for other reasons. They will use questionnaires and blo…

This study looks at whether children with ADHD have different levels of inflammation and nutrition markers compared to children without ADHD. Researchers will follow 80 children aged 7 to 17 for one year to see if these markers affect how well they respond to common ADHD medicati…

This study follows 100 adults who had an allergic reaction to contrast media (dye used in CT scans and other imaging) to see if the allergy persists over time. Participants will undergo repeat skin testing to check for ongoing sensitivity. The goal is to understand how long the a…

This study looks at how athletes at risk for patellar tendinopathy (jumper's knee) move during jumps. Researchers will use a camera system to track knee, hip, and ankle angles in 60 male athletes over 12 months. The goal is to find early movement changes that could lead to better…

This study aims to find out if tumor cells can be detected in the blood or spinal fluid of patients whose aggressive meningioma has come back. Researchers will take blood and spinal fluid samples from 15 adults with recurrent grade 2 or 3 meningioma. This is a proof-of-concept st…

This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors might lead to the disease. Participants provide blood, urine, stool, and saliva samples, and answer questions about their lifestyle. The goal is to identify triggers like smok…