Can a common altitude sickness drug help heart failure patients shed excess fluid?
NCT ID NCT07737964
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This phase 3 trial investigates whether adding acetazolamide—a drug often used for altitude sickness—to standard diuretics can improve fluid removal in people with heart failure who experience sudden fluid buildup. Participants take the medication for up to five days while being monitored remotely via a connected scale. The study aims to see if more patients lose over 2 kilograms of fluid weight compared to those receiving only standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- acetazolamide added to standard loop diuretics (furosemide)
- What this could lead to
- If it works, this could offer a better way to relieve fluid buildup in heart failure patients without needing hospitalization.
- What could go wrong
- This is an early-phase trial with 366 participants; acetazolamide may not improve outcomes and could cause side effects like electrolyte imbalances or kidney issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Avignon Hospital
Avignon, France
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Bicêtre Hospital
Le Kremlin-Bicêtre, France
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Cardiovascular Institute - Grenoble Mutualist Hospital Group
Grenoble, France
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Chartres Hospital
Chartres, France
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Cholet Hospital
Cholet, France
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Dreux Hospital
Dreux, France
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Ellipse Center Strasbourg
Strasbourg, France
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Hospital Beziers
Béziers, France
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Louis Pradel Hospital
Lyon, France
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Pôle Santé Sud - Le Mans
Le Mans, France
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Regional University Hospital Nancy
Nancy, France
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Sainte Musse Hospital Toulon
Toulon, France
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Sud Francilien Hospital
Corbeil-Essonnes, France
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The Confluent Private Hospital
Nantes, France
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University Hospital Amiens-Picardie
Amiens, France
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University Hospital Angers
Angers, France
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University Hospital Besançon
Besançon, France
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University Hospital Bordeaux
Bordeaux, France
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University Hospital Brest
Brest, France
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University Hospital Caen
Caen, France
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University Hospital Grenoble Alpes
Grenoble, France
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University Hospital Nîmes
Nîmes, France
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University Hospital Toulouse
Toulouse, France
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University hospital Montpellier
Montpellier, France
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Valenciennes Hospital
Valenciennes, France
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