Can extra progesterone boost IVF success? new trial investigates

NCT ID NCT07613528

Not yet recruiting Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether giving daily progesterone injections for 6 weeks after a positive pregnancy test can improve live birth rates in women with low progesterone levels. The study includes 214 women aged 18-37 who became pregnant through IVF. Half will receive the extra progesterone shots, and half will receive placebo injections, with neither the patients nor doctors knowing who gets what.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Progesterone (injectable and vaginal)
What this could lead to: If successful, this could show that extending progesterone shots for 6 weeks after a positive pregnancy test increases the chance of a live birth in women with low progesterone levels.
What could go wrong: This is a relatively small trial (214 participants) and only includes women aged 18-37 with specific progesterone levels, so results may not apply to everyone. The extra injections may cause discomfort or side effects without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW SERUM PROGESTERONE PREGNANCY PROGESTERONE SUPPLEMENTATION

Contacts and locations

Locations

CHU de Montpellier

Montpellier, 34295, France

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