New combo therapy aims to stop small liver cancers from coming back

NCT ID NCT04727307

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding two immunotherapy drugs (atezolizumab and bevacizumab) before and after a standard tumor-burning procedure (radiofrequency ablation) can prevent small liver cancers from returning. About 202 adults with early-stage liver cancer will be randomly assigned to receive either ablation alone or the drug combo plus ablation. The goal is to see if the combination improves recurrence-free survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma liver disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CH Perpignan

    Perpignan, France

  • CHRU de Nancy

    Nancy, France

  • CHU Amiens

    Amiens, France

  • CHU Dijon

    Dijon, France

  • CHU Nîmes

    Nîmes, France

  • CHU d'Angers

    Angers, France

  • CHU de Grenoble

    Grenoble, France

  • CHU de Lille

    Lille, France

  • CHU de Montpellier

    Montpellier, France

  • CHU de Nantes

    Nantes, France

  • CHU de Nice

    Nice, France

  • CHU de Poitiers

    Poitiers, France

  • CHU de Rennes

    Rennes, France

  • Centre Georges François Leclerc

    Dijon, France

  • Hôpital Beaujon

    Clichy, France

  • Hôpital Cochin

    Paris, France

  • Hôpital Jean Verdier

    Bondy, France

  • Hôpital Saint Joseph

    Marseille, France

  • Institut Gustave Roussy

    Villejuif, France