New hope for stiff lungs? drug trial targets scarring from autoimmune disease

NCT ID NCT06572384

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether belimumab (Benlysta) can stabilize or improve lung function in adults with interstitial lung disease caused by connective tissue diseases like rheumatoid arthritis or lupus. About 440 participants will receive either belimumab injections or a placebo, plus standard therapy, for a year. The main goal is to see if the drug helps preserve lung capacity and ease symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: belimumab (Benlysta)
What this could lead to: If it works, this could offer a new treatment option to slow or improve lung damage in people with connective tissue disease-related interstitial lung disease.
What could go wrong: This is a phase 3 trial, but results may not show benefit over placebo. Belimumab also carries risks like infections and allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

antisynthetase syndrome autoimmune disease connective tissue disorder dermatomyositis idiopathic inflammatory myopathy interstitial lung disease lung disorder mixed connective tissue disease polymyositis rheumatoid arthritis Sjogren syndrome systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG DISEASES, INTERSTITIAL

Contacts and locations

Locations

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Los Angeles, California, 90033, United States
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Los Angeles, California, 90095, United States
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Los Angeles, California, 92868, United States
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San Francisco, California, 94143, United States
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Upland, California, 91786, United States
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Gainesville, Florida, 32608, United States
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Naples, Florida, 34102, United States
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St Louis, Missouri, 63110, United States
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New York, New York, 10029, United States
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New York, New York, 10032, United States
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Potsdam, New York, 13676, United States
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Durham, North Carolina, 27710, United States
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Philadelphia, Pennsylvania, 19140, United States
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Houston, Texas, 77030, United States
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Temple, Texas, 76508, United States
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Salt Lake City, Utah, 84108, United States
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Buenos Aires, 1023, Argentina
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Buenos Aires, C1128AAF, Argentina
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Buenos Aires, C1425AGC, Argentina
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Ciudad Autonoma Buenos Aires, C1015ABO, Argentina
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Córdoba, X5000AAW, Argentina
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Mendoza, 5500, Argentina
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Rosario, S2002, Argentina
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San Miguel de Tucumán, T4000, Argentina
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Santa Fe, 3000, Argentina
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Adelaide, South Australia, 5000, Australia
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Woodville, South Australia, 5011, Australia
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Spearwood, Western Australia, 6163, Australia
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Brussels, 1090, Belgium
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Brussels, 1200, Belgium
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Liège, 4000, Belgium
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Namur, Belgium
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Barra Mansa, 27323240, Brazil
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Juiz de Fora, 36010-570, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90480000, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 04004-030, Brazil
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São Paulo, 05403-900, Brazil
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Montreal, Quebec, H3T 1E2, Canada
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Trois-Rivières, Quebec, G9A 4P3, Canada
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Beijing, 100020, China
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Beijing, 100730, China
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Chengdu, 610072, China
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Guangzhou, 510100, China
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Guangzhou, 510630, China
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Hangzhou, 310003, China
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Hangzhou, 310052, China
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Mianyang, China
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Nanjing, 210008, China
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Nanjing, 210029, China
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Nanning, 530000, China
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Shanghai, 200001, China
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Shanghai, 200040, China
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Shenyang, 110001, China
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Suzhou, China
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Tianjin, 300052, China
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Zhuzhou, 412007, China
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Angers, 49933, France
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Le Kremlin-Bicêtre, 94275, France
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Lille, 59037, France
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Pessac, 33604, France
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Rouen, 76000, France
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Toulouse, 31059, France
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Essen, 45293, Germany
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Mainz, 55131, Germany
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Minden, 32429, Germany
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Würzburg, 97080, Germany
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Athens, 106 76, Greece
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Athens, 124 62, Greece
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Athens, 12462, Greece
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Larissa, 41110, Greece
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Ancona, Italy
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Milan, 20132, Italy
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Milan, Italy
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Modena, 41124, Italy
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Naples, 80131, Italy
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Padova, Italy
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Pavia, 27100, Italy
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Pisa, 56126, Italy
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Roma, 00128, Italy
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Roma, Italy
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Udine, 33100, Italy
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Verona, 37134, Italy
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Aichi, 470-1192, Japan
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Fukuoka, 807-8556, Japan
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Fukuoka, 812-8582, Japan
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Hiroshima, 734-8551, Japan
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Hokkaido, 060-8648, Japan
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Kanagawa, 216-8511, Japan
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Miyagi, 983-8512, Japan
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Miyazaki, 889-1692, Japan
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Saitama, 350-0495, Japan
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Tokyo, 113-8519, Japan
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Tokyo, 113-8603, Japan
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Tokyo, 143-8541, Japan
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Tottori, 683-8504, Japan
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Yamanashi, 409-3898, Japan
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Chihuahua City, 31000, Mexico
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Guadalajara, 44650, Mexico
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Mexicali, 21200, Mexico
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Mexico City, 03310, Mexico
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Mérida, CP 97070, Mexico
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Monterrey, 64460, Mexico
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Maastricht, 6229 HX, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Utrecht, 3584 CX, Netherlands
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Panama City, 07126, Panama
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Panama City, 7002, Panama
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Panama City, 7099, Panama
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Panama City, Panama
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Panama City, Panama
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Bucheon Kyunggi-Do, 420-717, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Suwon Kyunggi-do, 443-721, South Korea
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Yongsan-Ku Seoul, South Korea
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Barcelona, 08025, Spain
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Barcelona, 08035, Spain
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Córdoba, 14004, Spain
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Granada, 18016, Spain
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Madrid, 28007, Spain
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Madrid, 28046, Spain
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Málaga, 29530, Spain
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Pamplona, 31008, Spain
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Santander, 39011, Spain
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Seville, 41013, Spain
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Birmingham, B9 5SS, United Kingdom
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Leicester, LE3 9QP, United Kingdom
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London, SW3 6NP, United Kingdom

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